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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Cylindrospermopsis

  • Methanol extracts made from Tychonema bourrellyi, Aphanizomenon flos-aquae and Cylindrospermopsis raciborskii showed the most pronounced inhibitory effects, Aqueous extracts made from Microcystis aeruginosa and T. bourrellyi possessed evident antibacterial properties [1].

High impact information on Cylindrospermopsis

  • Studies on the biosynthesis of cylindrospermopsin (1), a potent hepatotoxin associated with the cyanobacterium Cylindrospermopsis raciborskii, indicate that 1 is an acetogenin with guanidinoacetic acid serving as the starter unit of the polyketide chain [2].
  • The extract from cells of Cylindrospermopsis raciborskii was resuspended with 0.1 M carbonate buffer at pH 10.5, and pass through the double-cartridges column which was consisted of a styrene polymer cartridge and an anion exchange cartridge [3].
  • Poisoning of humans resulting from consumption of water affected by the toxic cyanobacterium Cylindrospermopsis raciborskii was first reported almost 20 years ago from Palm Island, northern Queensland, Australia. Since that time a great deal has been learned about this organism and cylindrospermopsin (CYN), the toxin it produces [4].
  • A nonaxenic strain of Cylindrospermopsis raciborskii Woloszynska (AWT 205) was grown in batch culture, with and without nitrate as the primary N source [5].


  1. Antibacterial properties of extracts from selected planktonic freshwater cyanobacteria--a comparative study of bacterial bioassays. Ostensvik, O., Skulberg, O.M., Underdal, B., Hormazabal, V. J. Appl. Microbiol. (1998) [Pubmed]
  2. Biosynthesis of cylindrospermopsin. Burgoyne, D.L., Hemscheidt, T.K., Moore, R.E., Runnegar, M.T. J. Org. Chem. (2000) [Pubmed]
  3. A new simply and effective fractionation method for cylindrospermopsin analyses. Kubo, T., Sano, T., Hosoya, K., Tanaka, N., Kaya, K. Toxicon (2005) [Pubmed]
  4. The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin. Griffiths, D.J., Saker, M.L. Environ. Toxicol. (2003) [Pubmed]
  5. Phenotypical variation in a toxic strain of the phytoplankter, Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) during batch culture. Hawkins, P.R., Putt, E., Falconer, I., Humpage, A. Environ. Toxicol. (2001) [Pubmed]
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