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Chemical Compound Review

Betacyamine     2-(diaminomethylideneamino) ethanoic acid

Synonyms: Betasyamine, Glykocyamin, glycocyamine, Guanidoacetate, CHEMBL281593, ...
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Disease relevance of Guanidoacetic acid


Psychiatry related information on Guanidoacetic acid


High impact information on Guanidoacetic acid


Chemical compound and disease context of Guanidoacetic acid


Biological context of Guanidoacetic acid


Anatomical context of Guanidoacetic acid


Associations of Guanidoacetic acid with other chemical compounds


Gene context of Guanidoacetic acid


Analytical, diagnostic and therapeutic context of Guanidoacetic acid


  1. Gyrate atrophy of the choroid and retina with hyperornithinemia. Deficient formation of guanidinoacetic acid from arginine. Sipilä, I., Simell, O., Arjomaa, P. J. Clin. Invest. (1980) [Pubmed]
  2. Lack of creatine in muscle and brain in an adult with GAMT deficiency. Schulze, A., Bachert, P., Schlemmer, H., Harting, I., Polster, T., Salomons, G.S., Verhoeven, N.M., Jakobs, C., Fowler, B., Hoffmann, G.F., Mayatepek, E. Ann. Neurol. (2003) [Pubmed]
  3. Brain creatine depletion: guanidinoacetate methyltransferase deficiency (improving with creatine supplementation). Leuzzi, V., Bianchi, M.C., Tosetti, M., Carducci, C., Cerquiglini, C.A., Cioni, G., Antonozzi, I. Neurology (2000) [Pubmed]
  4. Biochemical validation of a rat model for polycystic kidney disease: comparison of guanidino compound profile with the human condition. Torremans, A., Marescau, B., Kränzlin, B., Gretz, N., Billiouw, J.M., Vanholder, R., De Smet, R., Bouwman, K., Brouns, R., De Deyn, P.P. Kidney Int. (2006) [Pubmed]
  5. Removal of intracellular waste products by hemofiltration. Kimura, G., Kojima, S., Kawano, Y., Imanishi, M., Kuramochi, M., Omae, T. Am. J. Kidney Dis. (1989) [Pubmed]
  6. Evaluation of the mechanism underlying the inhibitory effect of guanidinoacetate on brain Na+, K+-ATPase activity. Zugno, A.I., Franzon, R., Chiarani, F., Bavaresco, C.S., Wannmacher, C.M., Wajner, M., Wyse, A.T. Int. J. Dev. Neurosci. (2004) [Pubmed]
  7. Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans. Item, C.B., Stöckler-Ipsiroglu, S., Stromberger, C., Mühl, A., Alessandrì, M.G., Bianchi, M.C., Tosetti, M., Fornai, F., Cioni, G. Am. J. Hum. Genet. (2001) [Pubmed]
  8. Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man. Stöckler, S., Isbrandt, D., Hanefeld, F., Schmidt, B., von Figura, K. Am. J. Hum. Genet. (1996) [Pubmed]
  9. S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. Niewmierzycka, A., Clarke, S. J. Biol. Chem. (1999) [Pubmed]
  10. Rat guanidinoacetate methyltransferase. Effect of site-directed alteration of an aspartic acid residue that is conserved across most mammalian S-adenosylmethionine-dependent methyltransferases. Takata, Y., Konishi, K., Gomi, T., Fujioka, M. J. Biol. Chem. (1994) [Pubmed]
  11. Prenatal diagnosis of guanidinoacetate methyltransferase deficiency: increased guanidinoacetate concentrations in amniotic fluid. Cheillan, D., Salomons, G.S., Acquaviva, C., Boisson, C., Roth, P., Cordier, M.P., François, L., Jakobs, C., Vianey-Saban, C. Clin. Chem. (2006) [Pubmed]
  12. Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats. Fukada, S., Setoue, M., Morita, T., Sugiyama, K. J. Nutr. (2006) [Pubmed]
  13. Studies on the precursor of methylguanidine in rats with renal failure. Yokozawa, T., Fujitsuka, N., Oura, H. Nephron (1991) [Pubmed]
  14. Study on impaired metabolism of guanidinoacetic acid in chronic renal failure rabbits with special reference to impaired conversion of arginine to guanidinoacetic acid. Kuroda, M. Nephron (1993) [Pubmed]
  15. Functional modeling and phylogenetic distribution of putative cylindrospermopsin biosynthesis enzymes. Kellmann, R., Mills, T., Neilan, B.A. J. Mol. Evol. (2006) [Pubmed]
  16. Alternative splicing produces transcripts coding for alpha and beta chains of a hetero-dimeric phosphagen kinase. Ellington, W.R., Yamashita, D., Suzuki, T. Gene (2004) [Pubmed]
  17. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Stead, L.M., Au, K.P., Jacobs, R.L., Brosnan, M.E., Brosnan, J.T. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  18. Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate. Zugno, A.I., Stefanello, F.M., Streck, E.L., Calcagnotto, T., Wannmacher, C.M., Wajner, M., Wyse, A.T. Int. J. Dev. Neurosci. (2003) [Pubmed]
  19. Evolution of phosphagen kinase VII. Isolation of glycocyamine kinase from the polychaete Neanthes diversicolor and the cDNA-derived amino acid sequences of alpha and beta chains. Suzuki, T., Nishimura, Y., Umekawa, M., Yamamoto, Y., Kawamichi, H., Furukohri, T. J. Protein Chem. (1999) [Pubmed]
  20. Metabolism of glycine in primary astroglial cells: synthesis of creatine, serine, and glutathione. Dringen, R., Verleysdonk, S., Hamprecht, B., Willker, W., Leibfritz, D., Brand, A. J. Neurochem. (1998) [Pubmed]
  21. In vitro study of the potential role of guanidines in leukocyte functions related to atherogenesis and infection. Glorieux, G.L., Dhondt, A.W., Jacobs, P., Van Langeraert, J., Lameire, N.H., De Deyn, P.P., Vanholder, R.C. Kidney Int. (2004) [Pubmed]
  22. Oxidative stress alters arginine metabolism in rat brain: effect of sub-convulsive hyperbaric oxygen exposure. Ito, T., Yufu, K., Mori, A., Packer, L. Neurochem. Int. (1996) [Pubmed]
  23. Creatine synthesis and transport systems in the male rat reproductive tract. Lee, H., Kim, J.H., Chae, Y.J., Ogawa, H., Lee, M.H., Gerton, G.L. Biol. Reprod. (1998) [Pubmed]
  24. Renal arginine metabolism. Brosnan, M.E., Brosnan, J.T. J. Nutr. (2004) [Pubmed]
  25. Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase. Kan, H.E., Renema, W.K., Isbrandt, D., Heerschap, A. J. Physiol. (Lond.) (2004) [Pubmed]
  26. Identification of guanidino succinate as a putative endogenous source of the endothelium derived relaxing factor. Thomas, G., Ramwell, P.W. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  27. Reversible inactivation of recombinant rat liver guanidinoacetate methyltransferase by glutathione disulfide. Konishi, K., Fujioka, M. Arch. Biochem. Biophys. (1991) [Pubmed]
  28. Cerebral (1)H MR spectroscopy showing elevation of brain guanidinoacetate in argininosuccinate lyase deficiency. Sijens, P.E., Reijngoud, D.J., Soorani-Lunsing, R.J., Oudkerk, M., van Spronsen, F.J. Mol. Genet. Metab. (2006) [Pubmed]
  29. A role for guanidino compounds in the brain. Hiramatsu, M. Mol. Cell. Biochem. (2003) [Pubmed]
  30. Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Schmidt, A., Marescau, B., Boehm, E.A., Renema, W.K., Peco, R., Das, A., Steinfeld, R., Chan, S., Wallis, J., Davidoff, M., Ullrich, K., Waldschütz, R., Heerschap, A., De Deyn, P.P., Neubauer, S., Isbrandt, D. Hum. Mol. Genet. (2004) [Pubmed]
  31. Clinical characteristics and diagnostic clues in inborn errors of creatine metabolism. Stromberger, C., Bodamer, O.A., Stöckler-Ipsiroglu, S. J. Inherit. Metab. Dis. (2003) [Pubmed]
  32. Automated high-performance liquid chromatographic method for the determination of guanidinoacetic acid in dried blood spots: a tool for early diagnosis of guanidinoacetate methyltransferase deficiency. Carducci, C., Birarelli, M., Santagata, P., Leuzzi, V., Carducci, C., Antonozzi, I. J. Chromatogr. B Biomed. Sci. Appl. (2001) [Pubmed]
  33. Cation-exchange chromatography of guanidine derivatives in plasma of patients with chronic renal failure. Perez, G., Rey, A., Micklus, M., Stein, I. Clin. Chem. (1976) [Pubmed]
  34. HPLC assay for guanidinoacetate methyltransferase. Grazia Alessandrì, M., Celati, L., Battini, R., Baldinotti, F., Item, C., Leuzzi, V., Cioni, G. Anal. Biochem. (2004) [Pubmed]
  35. Sustained increase of methylguanidine in rats after amygdala or hippocampal kindling. Shimizu, Y., Morimoto, K., Kuroda, S., Mori, A. Epilepsy Res. (1995) [Pubmed]
  36. Stable isotope dilution method for the determination of guanidinoacetic acid by gas chromatography/mass spectrometry. Fingerhut, R. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
  37. Cloning and expression of a lombricine kinase from an echiuroid worm: insights into structural correlates of substrate specificity. Ellington, W.R., Bush, J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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