Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Genes, nef

Hahn, T. et al., Murti, K.G. et al., Miller, M.D. et al., Lu, Y. et al., Karn, J., et al.

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Disease relevance of Genes, nef

Provirus defective in both the rev and nef genes (Rev-Nef-) was also nonreplicating but had normal Tat function [1].
Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry [2].

High impact information on Genes, nef

The nef gene is dispensible for virus growth but may limit virus spread by downregulating the levels of cellular surface proteins such as the CD4 receptor [3].
An examination of the sequence of the SF2 nef gene revealed a putative nuclear targeting sequence that was previously found in several other eukaryotic nucleoplasmic proteins [4].
The suppressive effect of the NRE did not depend upon the negative regulatory gene (nef), as both NRE-positive and NRE-negative viruses were defective for nef [5].
To determine the evolutionary dynamics and conservation of functionality of the human immunodeficiency virus type 1 (HIV-1) NEF gene during maternal-fetal transmission, we analyzed NEF sequences from seven mother-infant pairs following perinatal transmission, including a mother with infected twin infants [6].

References

Rev-induced modulation of Nef protein underlies temporal regulation of human immunodeficiency virus replication. Ahmad, N., Maitra, R.K., Venkatesan, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry. Miller, M.D., Warmerdam, M.T., Page, K.A., Feinberg, M.B., Greene, W.C. J. Virol. (1995) [Pubmed]
Control of human immunodeficiency virus replication by the tat, rev, nef and protease genes. Karn, J. Curr. Opin. Immunol. (1991) [Pubmed]
Highly localized tracks of human immunodeficiency virus type 1 Nef in the nucleus of cells of a human CD4+ T-cell line. Murti, K.G., Brown, P.S., Ratner, L., Garcia, J.V. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication. Lu, Y., Stenzel, M., Sodroski, J.G., Haseltine, W.A. J. Virol. (1989) [Pubmed]
Evaluation of genetic diversity of human immunodeficiency virus type 1 NEF gene associated with vertical transmission. Hahn, T., Ramakrishnan, R., Ahmad, N. J. Biomed. Sci. (2003) [Pubmed]

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