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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Coronaviridae


High impact information on Coronaviridae

  • The AflII site engineered between ORFs 5 and 6 was subsequently used to generate a virus in which the ectodomain of the ORF 6-encoded M protein was extended with nine amino acids derived from the extreme N-terminus of the homologous protein of mouse hepatitis virus (MHV; family Coronaviridae, order Nidovirales) [3].
  • The ADRP (APPR-1'') domain - unique to the Coronaviridae - was also located in BoTV pp1a [4].
  • Nucleocapsid (N) proteins of the Coronaviridae family have no discernable homology, but they share a common nucleolar-cytoplasmic distribution pattern [5].


  1. The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. Marsden, P.A., Ning, Q., Fung, L.S., Luo, X., Chen, Y., Mendicino, M., Ghanekar, A., Scott, J.A., Miller, T., Chan, C.W., Chan, M.W., He, W., Gorczynski, R.M., Grant, D.R., Clark, D.A., Phillips, M.J., Levy, G.A. J. Clin. Invest. (2003) [Pubmed]
  2. Coronavirus genome: prediction of putative functional domains in the non-structural polyprotein by comparative amino acid sequence analysis. Gorbalenya, A.E., Koonin, E.V., Donchenko, A.P., Blinov, V.M. Nucleic Acids Res. (1989) [Pubmed]
  3. Genetic manipulation of equine arteritis virus using full-length cDNA clones: separation of overlapping genes and expression of a foreign epitope. de Vries, A.A., Glaser, A.L., Raamsman, M.J., de Haan, C.A., Sarnataro, S., Godeke, G.J., Rottier, P.J. Virology (2000) [Pubmed]
  4. The complete sequence of the bovine torovirus genome. Draker, R., Roper, R.L., Petric, M., Tellier, R. Virus Res. (2006) [Pubmed]
  5. Nuclear/nucleolar localization properties of C-terminal nucleocapsid protein of SARS coronavirus. Timani, K.A., Liao, Q., Ye, L., Zeng, Y., Liu, J., Zheng, Y., Ye, L., Yang, X., Lingbao, K., Gao, J., Zhu, Y. Virus Res. (2005) [Pubmed]
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