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MeSH Review

Parvoviridae

 
 
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Disease relevance of Parvoviridae

  • Parvovirus B19 (B19) was discovered in 1974 and is the only member of the family Parvoviridae known to be pathogenic in humans [1].
  • STUDY DESIGN AND METHODS: A recently developed pasteurization of human apolipoprotein A-I (apoA-I), which is performed at 60 degrees C for 10 hours in the presence of guanidine hydrochloride (GdnHCl), was validated by using a series of model viruses, including members of the families parvoviridae and picornaviridae [2].
 

High impact information on Parvoviridae

  • The Parvoviridae evolutionary potential in mammal infections has been modeled in the experimental system formed by the immunodeficient scid mouse infected by the minute virus of mice (MVM) under distinct immune and adaptive pressures [3].
  • The second one related to the Parvoviridae family, is a 25 nm in diameter icosahedral virus with a DNA genome and a capsid constituted of 4 polypeptides of respectively, 90,000; 64,000; 56,000 and 43,500 daltons [4].
 

Anatomical context of Parvoviridae

  • Human parvovirus B19 is a member of the autonomous parvoviridae but in contrast to other members of the genus has not been shown to agglutinate red blood cells [5].

References

  1. Human parvovirus B19. Heegaard, E.D., Brown, K.E. Clin. Microbiol. Rev. (2002) [Pubmed]
  2. Virus inactivation of plasma-derived proteins by pasteurization in the presence of guanidine hydrochloride. Schlegel, A., Immelmann, A., Kempf, C. Transfusion (2001) [Pubmed]
  3. Parvovirus variation for disease: a difference with RNA viruses? López-Bueno, A., Villarreal, L.P., Almendral, J.M. Curr. Top. Microbiol. Immunol. (2006) [Pubmed]
  4. Evidence for two small viruses persistently infecting established cell lines of Phthorimaea operculella, deriving from embryos of the potato tuber moth. Lery, X., Zeddam, J.L., Giannotti, J., Abol-Ela, S. New Microbiol. (1998) [Pubmed]
  5. Haemagglutination by parvovirus B19. Brown, K.E., Cohen, B.J. J. Gen. Virol. (1992) [Pubmed]
 
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