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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Parvovirus


High impact information on Parvovirus

  • We identified viral transcripts in parvovirus H1-infected rodent cells using the S1 nuclease mapping technique of Berk and Sharp (1977, 1978) [5].
  • Association of parvoviruses with rheumatoid arthritis of humans [6].
  • It has not been established that RA-1 and existing parvoviruses of mammalian species are related [6].
  • Crystallographic studies of a related parvovirus (canine parvovirus) suggested the unique amino-terminal portion of VP1 assumed an internal position within the viral capsid [3].
  • In neutralization experiments, in which erythroid colony formation in vitro was used as an assay of parvovirus activity, sera from patients with poor reactivity on immunoblotting were also inadequate in inhibiting viral infectivity [7].

Chemical compound and disease context of Parvovirus


Biological context of Parvovirus


Anatomical context of Parvovirus


Gene context of Parvovirus

  • The results suggest that the activity of complexes formed by the NS polypeptides and recruited cellular factors restrict parvovirus DNA amplification in a cell type-dependent manner and that NS functions may in addition determine MVM host range acting at postencapsidation steps of viral maturation [21].
  • Furthermore, these data suggest novel mechanisms whereby parvovirus B19 infection may contribute to rheumatoid arthritis and unsuccessful pregnancy [22].
  • Experiments were performed to determine at which level parvovirus expression is up-regulated in ras transformants [23].
  • Altogether, these data show that the IL-2 expressing H1 vector was a more potent antineoplastic agent than the parental virus, and point to the possible application of recombinant autonomous parvoviruses toward therapy of some human tumors [24].
  • The sequence shows extensive homology with other parvoviruses such as MVM, H-1, CPV, and FPV in the capsid coding region [25].

Analytical, diagnostic and therapeutic context of Parvovirus


  1. Treatment of parvovirus B19-associated polyarteritis nodosa with intravenous immune globulin. Viguier, M., Guillevin, L., Laroche, L. N. Engl. J. Med. (2001) [Pubmed]
  2. Risk factors for parvovirus B19 infection in pregnancy. Valeur-Jensen, A.K., Pedersen, C.B., Westergaard, T., Jensen, I.P., Lebech, M., Andersen, P.K., Aaby, P., Pedersen, B.N., Melbye, M. JAMA (1999) [Pubmed]
  3. Unique region of the minor capsid protein of human parvovirus B19 is exposed on the virion surface. Rosenfeld, S.J., Yoshimoto, K., Kajigaya, S., Anderson, S., Young, N.S., Field, A., Warrener, P., Bansal, G., Collett, M.S. J. Clin. Invest. (1992) [Pubmed]
  4. Identification of a novel simian parvovirus in cynomolgus monkeys with severe anemia. A paradigm of human B19 parvovirus infection. O'Sullivan, M.G., Anderson, D.C., Fikes, J.D., Bain, F.T., Carlson, C.S., Green, S.W., Young, N.S., Brown, K.E. J. Clin. Invest. (1994) [Pubmed]
  5. Expression of the autonomous parvovirus H1 genome: evidence for a single transcriptional unit and multiple spliced polyadenylated transcripts. Green, M.R., Lebovitz, R.M., Roeder, R.G. Cell (1979) [Pubmed]
  6. Association of parvoviruses with rheumatoid arthritis of humans. Simpson, R.W., McGinty, L., Simon, L., Smith, C.A., Godzeski, C.W., Boyd, R.J. Science (1984) [Pubmed]
  7. Immune response to B19 parvovirus and an antibody defect in persistent viral infection. Kurtzman, G.J., Cohen, B.J., Field, A.M., Oseas, R., Blaese, R.M., Young, N.S. J. Clin. Invest. (1989) [Pubmed]
  8. Aplastic crisis due to parvovirus infection in pyruvate kinase deficiency. Duncan, J.R., Potter, C.B., Cappellini, M.D., Kurtz, J.B., Anderson, M.J., Weatherall, D.J. Lancet (1983) [Pubmed]
  9. A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species. Allander, T., Emerson, S.U., Engle, R.E., Purcell, R.H., Bukh, J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  10. Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry. Weigel-Kelley, K.A., Yoder, M.C., Srivastava, A. Blood (2003) [Pubmed]
  11. A human parvovirus, adeno-associated virus, as a eucaryotic vector: transient expression and encapsidation of the procaryotic gene for chloramphenicol acetyltransferase. Tratschin, J.D., West, M.H., Sandbank, T., Carter, B.J. Mol. Cell. Biol. (1984) [Pubmed]
  12. The rat diabetes susceptibility locus Iddm4 and at least one additional gene are required for autoimmune diabetes induced by viral infection. Blankenhorn, E.P., Rodemich, L., Martin-Fernandez, C., Leif, J., Greiner, D.L., Mordes, J.P. Diabetes (2005) [Pubmed]
  13. Resistance to parvovirus B19 infection due to lack of virus receptor (erythrocyte P antigen). Brown, K.E., Hibbs, J.R., Gallinella, G., Anderson, S.M., Lehman, E.D., McCarthy, P., Young, N.S. N. Engl. J. Med. (1994) [Pubmed]
  14. Frequency of human parvovirus B19 infection in intrauterine fetal death. Tolfvenstam, T., Papadogiannakis, N., Norbeck, O., Petersson, K., Broliden, K. Lancet (2001) [Pubmed]
  15. Association of parvovirus B19 genome in children with myocarditis and cardiac allograft rejection: diagnosis using the polymerase chain reaction. Schowengerdt, K.O., Ni, J., Denfield, S.W., Gajarski, R.J., Bowles, N.E., Rosenthal, G., Kearney, D.L., Price, J.K., Rogers, B.B., Schauer, G.M., Chinnock, R.E., Towbin, J.A. Circulation (1997) [Pubmed]
  16. Epidemiology of human parvovirus B19 in children with sickle cell disease. Smith-Whitley, K., Zhao, H., Hodinka, R.L., Kwiatkowski, J., Cecil, R., Cecil, T., Cnaan, A., Ohene-Frempong, K. Blood (2004) [Pubmed]
  17. Persistence of parvovirus B19 DNA in synovial membranes of young patients with and without chronic arthropathy. Söderlund, M., von Essen, R., Haapasaari, J., Kiistala, U., Kiviluoto, O., Hedman, K. Lancet (1997) [Pubmed]
  18. Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS. Frickhofen, N., Abkowitz, J.L., Safford, M., Berry, J.M., Antunez-de-Mayolo, J., Astrow, A., Cohen, R., Halperin, I., King, L., Mintzer, D. Ann. Intern. Med. (1990) [Pubmed]
  19. Parvovirus B19 promoter at map unit 6 confers autonomous replication competence and erythroid specificity to adeno-associated virus 2 in primary human hematopoietic progenitor cells. Wang, X.S., Yoder, M.C., Zhou, S.Z., Srivastava, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. First continuous propagation of B19 parvovirus in a cell line. Shimomura, S., Komatsu, N., Frickhofen, N., Anderson, S., Kajigaya, S., Young, N.S. Blood (1992) [Pubmed]
  21. Genome replication and postencapsidation functions mapping to the nonstructural gene restrict the host range of a murine parvovirus in human cells. Rubio, M.P., Guerra, S., Almendral, J.M. J. Virol. (2001) [Pubmed]
  22. Impaired gamma interferon responses against parvovirus B19 by recently infected children. Corcoran, A., Doyle, S., Waldron, D., Nicholson, A., Mahon, B.P. J. Virol. (2000) [Pubmed]
  23. Initiation of transcription from the minute virus of mice P4 promoter is stimulated in rat cells expressing a c-Ha-ras oncogene. Spegelaere, P., van Hille, B., Spruyt, N., Faisst, S., Cornelis, J.J., Rommelaere, J. J. Virol. (1991) [Pubmed]
  24. Highly efficient transduction and expression of cytokine genes in human tumor cells by means of autonomous parvovirus vectors; generation of antitumor responses in recipient mice. Haag, A., Menten, P., Van Damme, J., Dinsart, C., Rommelaere, J., Cornelis, J.J. Hum. Gene Ther. (2000) [Pubmed]
  25. Nucleotide sequence analysis of the capsid genes and the right-hand terminal palindrome of porcine parvovirus, strain NADL-2. Vasudevacharya, J., Basak, S., Srinivas, R.V., Compans, R.W. Virology (1989) [Pubmed]
  26. Influence of adeno-associated virus on adherence and growth properties of normal cells. Bantel-Schaal, U., Stöhr, M. J. Virol. (1992) [Pubmed]
  27. The infectivity and lytic activity of minute virus of mice wild-type and derived vector particles are strikingly different. Lang, S.I., Boelz, S., Stroh-Dege, A.Y., Rommelaere, J., Dinsart, C., Cornelis, J.J. J. Virol. (2005) [Pubmed]
  28. Human parvovirus B19 can infect cynomolgus monkey marrow cells in tissue culture. Gallinella, G., Anderson, S.M., Young, N.S., Brown, K.E. J. Virol. (1995) [Pubmed]
  29. Sequence homology between the structural proteins of Kilham rat virus. Brown, D.D., Salzman, L.A. J. Virol. (1984) [Pubmed]
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