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Gene Review

APOA1  -  apolipoprotein A-I

Homo sapiens

Synonyms: Apo-AI, ApoA-I, Apolipoprotein A-I, Apolipoprotein A1
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Disease relevance of APOA1


Psychiatry related information on APOA1


High impact information on APOA1


Chemical compound and disease context of APOA1


Biological context of APOA1


Anatomical context of APOA1


Associations of APOA1 with chemical compounds

  • On the other hand, apoprotein A1 (APOA1) and triglyceride levels were not different between the two groups [1].
  • The genes coding for three proteins of the plasma lipid transport system--apolipoproteins A1 (APOA1), C3 (APOC3), and A4 (APOA4)--are closely linked and tandemly organized on the long arm of human chromosome 11 [21].
  • Variation in the apolipoprotein A1 gene (APOA1) might influence the function of the protein, and thus brain cholesterol metabolism, leading to an increased risk for AD [25].
  • The variant, ApoA1 Baltimore, was due to a mutation at codon 34 of the third exon of the APOA1 gene (CGA to CTA) that resulted in an arginine-to-leucine substitution at the tenth amino acid of the mature ApoA1 and a change in charge of -1 [26].
  • Gene-drug interaction: additive influence of mutant APOA1 and testosterone on plasma HDL-cholesterol [27].

Physical interactions of APOA1


Enzymatic interactions of APOA1


Regulatory relationships of APOA1


Other interactions of APOA1


Analytical, diagnostic and therapeutic context of APOA1


  1. Relation of parental history of early myocardial infarction to the level of apoprotein B in men. Cambien, F., Warnet, J.M., Jacqueson, A., Ducimetiere, P., Richard, J.L., Claude, J.R. Circulation (1987) [Pubmed]
  2. Insulin-receptor and apolipoprotein genes contribute to development of NIDDM in Chinese Americans. Xiang, K.S., Cox, N.J., Sanz, N., Huang, P., Karam, J.H., Bell, G.I. Diabetes (1989) [Pubmed]
  3. Characterization of a new mouse model for human apolipoprotein A-I/C-III/A-IV deficiency. Mezdour, H., Larigauderie, G., Castro, G., Torpier, G., Fruchart, J., Nowak, M., Fruchart, J.C., Rouis, M., Maeda, N. J. Lipid Res. (2006) [Pubmed]
  4. Serum levels of leptin, insulin, and lipids in relation to breast cancer in china. Han, C., Zhang, H.T., Du, L., Liu, X., Jing, J., Zhao, X., Yang, X., Tian, B. Endocrine (2005) [Pubmed]
  5. Serum apolipoprotein profile of patients with chronic renal failure. Attman, P.O., Alaupovic, P., Gustafson, A. Kidney Int. (1987) [Pubmed]
  6. Genetic and environmental contributions to serum retinol and alpha-tocopherol concentrations: the Stanislas Family Study. Gueguen, S., Leroy, P., Gueguen, R., Siest, G., Visvikis, S., Herbeth, B. Am. J. Clin. Nutr. (2005) [Pubmed]
  7. Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease. Houlden, H., Crook, R., Duff, K., Hutton, M., Collinge, J., Roques, P., Rossor, M., Hardy, J. Neurosci. Lett. (1995) [Pubmed]
  8. Dietary modification of high density lipoprotein phospholipid and influence on cellular cholesterol efflux. Gillotte, K.L., Lund-Katz, S., de la Llera-Moya, M., Parks, J.S., Rudel, L.L., Rothblat, G.H., Phillips, M.C. J. Lipid Res. (1998) [Pubmed]
  9. The relation of high density lipoprotein cholesterol and its subfractions to apolipoprotein A-I and fasting triglycerides: the role of environmental factors. The Atherosclerosis Risk in Communities (ARIC) Study. Patsch, W., Sharrett, A.R., Sorlie, P.D., Davis, C.E., Brown, S.A. Am. J. Epidemiol. (1992) [Pubmed]
  10. Apolipoprotein A-I/apolipoprotein B ratio and aggression in violent and nonviolent young adult males. Troisi, A., D'Argenio, A. Journal of psychiatric research. (2006) [Pubmed]
  11. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. Stampfer, M.J., Sacks, F.M., Salvini, S., Willett, W.C., Hennekens, C.H. N. Engl. J. Med. (1991) [Pubmed]
  12. Increased concentrations of cholestanol and apolipoprotein B in the cerebrospinal fluid of patients with cerebrotendinous xanthomatosis. Effect of chenodeoxycholic acid. Salen, G., Berginer, V., Shore, V., Horak, I., Horak, E., Tint, G.S., Shefer, S. N. Engl. J. Med. (1987) [Pubmed]
  13. Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. Ordovas, J.M., Schaefer, E.J., Salem, D., Ward, R.H., Glueck, C.J., Vergani, C., Wilson, P.W., Karathanasis, S.K. N. Engl. J. Med. (1986) [Pubmed]
  14. The relation of apolipoproteins A-I and B in children to parental myocardial infarction. Freedman, D.S., Srinivasan, S.R., Shear, C.L., Franklin, F.A., Webber, L.S., Berenson, G.S. N. Engl. J. Med. (1986) [Pubmed]
  15. Substitutions of glutamate 110 and 111 in the middle helix 4 of human apolipoprotein A-I (apoA-I) by alanine affect the structure and in vitro functions of apoA-I and induce severe hypertriglyceridemia in apoA-I-deficient mice. Chroni, A., Kan, H.Y., Kypreos, K.E., Gorshkova, I.N., Shkodrani, A., Zannis, V.I. Biochemistry (2004) [Pubmed]
  16. Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporter. Nofer, J.R., Remaley, A.T., Feuerborn, R., Wolinnska, I., Engel, T., von Eckardstein, A., Assmann, G. J. Lipid Res. (2006) [Pubmed]
  17. Are the effects of tamoxifen on the serum lipid profile modified by apolipoprotein E phenotypes? Liberopoulos, E., Karabina, S.A., Tselepis, A., Bairaktari, E., Nicolaides, C., Pavlidis, N., Elisaf, M. Oncology (2002) [Pubmed]
  18. HDL and clinical and biochemical correlates in Italian non-smoker women. Bigazzi, F., Pino, B.D., Forastiere, F., Pistelli, R., Rossi, G., Simoni, M., Baldacci, S., Viegi, G., Bionda, A., Sampietro, T. Clin. Chem. Lab. Med. (2004) [Pubmed]
  19. Extended haplotypes and linkage disequilibrium between 11 markers at the APOA1-C3-A4 gene cluster on chromosome 11. Benlian, P., Boileau, C., Loux, N., Pastier, D., Masliah, J., Coulon, M., Nigou, M., Ragab, A., Guimard, J., Ruidavets, J.B. Am. J. Hum. Genet. (1991) [Pubmed]
  20. DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis. Karathanasis, S.K., Ferris, E., Haddad, I.A. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  21. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Karathanasis, S.K., Oettgen, P., Haddad, I.A., Antonarakis, S.E. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  22. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons. Wang, Q.F., Liu, X., O'Connell, J., Peng, Z., Krauss, R.M., Rainwater, D.L., VandeBerg, J.L., Rubin, E.M., Cheng, J.F., Pennacchio, L.A. Hum. Mol. Genet. (2004) [Pubmed]
  23. Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux. Kockx, M., Rye, K.A., Gaus, K., Quinn, C.M., Wright, J., Sloane, T., Sviridov, D., Fu, Y., Sullivan, D., Burnett, J.R., Rust, S., Assmann, G., Anantharamaiah, G.M., Palgunachari, M.N., Katz, S.L., Phillips, M.C., Dean, R.T., Jessup, W., Kritharides, L. J. Biol. Chem. (2004) [Pubmed]
  24. Role of apolipoprotein A-IV in hepatic lipase-catalyzed dolichol acylation and phospholipid hydrolysis. Sindelar, P.J., Chojnacki, I., Valtersson, C. Biochemistry (1997) [Pubmed]
  25. APOA1 polymorphism influences risk for early-onset nonfamiliar AD. Vollbach, H., Heun, R., Morris, C.M., Edwardson, J.A., McKeith, I.G., Jessen, F., Schulz, A., Maier, W., Kölsch, H. Ann. Neurol. (2005) [Pubmed]
  26. Apolipoprotein A1 Baltimore (Arg10----Leu), a new ApoA1 variant. Ladias, J.A., Kwiterovich, P.O., Smith, H.H., Karathanasis, S.K., Antonarakis, S.E. Hum. Genet. (1990) [Pubmed]
  27. Gene-drug interaction: additive influence of mutant APOA1 and testosterone on plasma HDL-cholesterol. Keyhan, G., Rosset, J., Wang, J., Miller, D., McManus, R., Hegele, R.A. Clin. Biochem. (2002) [Pubmed]
  28. Structure of apolipoprotein A-I in three homogeneous, reconstituted high density lipoprotein particles. Wald, J.H., Krul, E.S., Jonas, A. J. Biol. Chem. (1990) [Pubmed]
  29. Apolipoprotein A-I directly interacts with amyloid precursor protein and inhibits A beta aggregation and toxicity. Koldamova, R.P., Lefterov, I.M., Lefterova, M.I., Lazo, J.S. Biochemistry (2001) [Pubmed]
  30. Assignment of the binding site for haptoglobin on apolipoprotein A-I. Spagnuolo, M.S., Cigliano, L., D'Andrea, L.D., Pedone, C., Abrescia, P. J. Biol. Chem. (2005) [Pubmed]
  31. Differential effect of lysophospholipids on activities of human plasma paraoxonase1, either soluble or lipid-bound. Park, C.H., Nguyen, S.D., Kim, M.R., Jeong, T.S., Sok, D.E. Lipids (2006) [Pubmed]
  32. Serum lipids and apolipoproteins in women with breast masses. Lane, D.M., Boatman, K.K., McConathy, W.J. Breast Cancer Res. Treat. (1995) [Pubmed]
  33. Apolipoprotein A-I activates protein kinase C alpha signaling to phosphorylate and stabilize ATP binding cassette transporter A1 for the high density lipoprotein assembly. Yamauchi, Y., Hayashi, M., Abe-Dohmae, S., Yokoyama, S. J. Biol. Chem. (2003) [Pubmed]
  34. Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor. Ahmed, Z., Ravandi, A., Maguire, G.F., Emili, A., Draganov, D., La Du, B.N., Kuksis, A., Connelly, P.W. J. Biol. Chem. (2001) [Pubmed]
  35. Tyrosine modification is not required for myeloperoxidase-induced loss of apolipoprotein A-I functional activities. Peng, D.Q., Wu, Z., Brubaker, G., Zheng, L., Settle, M., Gross, E., Kinter, M., Hazen, S.L., Smith, J.D. J. Biol. Chem. (2005) [Pubmed]
  36. A purification method for apolipoprotein A-I and A-II. Peitsch, M.C., Kress, A., Lerch, P.G., Morgenthaler, J.J., Isliker, H., Heiniger, H.J. Anal. Biochem. (1989) [Pubmed]
  37. Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter. Haidar, B., Denis, M., Marcil, M., Krimbou, L., Genest, J. J. Biol. Chem. (2004) [Pubmed]
  38. Hyperalphalipoproteinemia in human lecithin cholesterol acyltransferase transgenic rabbits. In vivo apolipoprotein A-I catabolism is delayed in a gene dose-dependent manner. Brousseau, M.E., Santamarina-Fojo, S., Zech, L.A., Bérard, A.M., Vaisman, B.L., Meyn, S.M., Powell, D., Brewer, H.B., Hoeg, J.M. J. Clin. Invest. (1996) [Pubmed]
  39. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. Pászty, C., Maeda, N., Verstuyft, J., Rubin, E.M. J. Clin. Invest. (1994) [Pubmed]
  40. Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a novel cholesterol efflux accelerator. Glaros, E.N., Kim, W.S., Quinn, C.M., Wong, J., Gelissen, I., Jessup, W., Garner, B. J. Biol. Chem. (2005) [Pubmed]
  41. The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Garasto, S., Rose, G., Derango, F., Berardelli, M., Corsonello, A., Feraco, E., Mari, V., Maletta, R., Bruni, A., Franceschi, C., Carotenuto, L., De Benedictis, G. Ann. Hum. Genet. (2003) [Pubmed]
  42. The estimation of gametic disequilibrium between DNA markers in candidate genes for coronary artery disease (CAD) and the associations of gene complexes with risk factors for CAD. Spiridonova, M.G., Stepanov, V.A., Puzyrev, V.P., Karpov, R.S. International journal of circumpolar health. (2001) [Pubmed]
  43. Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Crauwels, H.M., Van Hove, C.E., Holvoet, P., Herman, A.G., Bult, H. Cardiovasc. Res. (2003) [Pubmed]
  44. Moderate hyperalphalipoproteinaemia in a Brazilian population is related to lipoprotein lipase activity, apolipoprotein A-I concentration, age and body mass index. Alarcon, S.B., Oliveira, H.C., Harada, L.M., Nunes, V.S., Kaplan, D., Quintão, E.C., de Faria, E.C. Clin. Sci. (2004) [Pubmed]
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