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MeSH Review

Nail Diseases

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High impact information on Nail Diseases

  • All six recipients of ketoconazole had remission of symptoms and virtually complete regression of mucosal, skin, and nail lesions, whereas only two of the six receiving placebo had even temporary mucosal clearing, and none had improvement of skin or nail disease [1].
  • Extension of this observation to human hereditary hair and nail diseases includes population analyses of human hair keratin genes for natural sequence variations in the corresponding sites [2].
  • BACKGROUND: Hereditary subtotal leuconychia is a rare nail disease [3].
  • In severe nail disease, where there is a hypertrophic element, injection therapy with triamcinolone may be helpful [4].


  1. Treatment of chronic mucocutaneous candidiasis with ketoconazole: a controlled clinical trial. Petersen, E.A., Alling, D.W., Kirkpatrick, C.H. Ann. Intern. Med. (1980) [Pubmed]
  2. The region coding for the helix termination motif and the adjacent intron 6 of the human type I hair keratin gene hHa2 contains three natural, closely spaced polymorphic sites. Winter, H., Rogers, M.A., Mahr, B., Cremer, M., Krieg, T., Navsaria, H.A., Leigh, I.M., Schweizer, J. J. Invest. Dermatol. (1996) [Pubmed]
  3. Hereditary 'white nails': a genetic and structural study. Norgett, E.E., Wolf, F., Balme, B., Leigh, I.M., Perrot, H., Kelsell, D.P., Haftek, M. Br. J. Dermatol. (2004) [Pubmed]
  4. Management of nail psoriasis. de Berker, D. Clin. Exp. Dermatol. (2000) [Pubmed]
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