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Chemical Compound Review

AC1O5DGV     (11S,16R)-9-fluoro-11,16,17- trihydroxy-17...

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Disease relevance of triamcinolone


Psychiatry related information on triamcinolone

  • According to the period of maximum sensitivity revealed by a time response study triamcinolone was injected as a single dose (2 mg/kg, i.m.) on day 11 at 8 a.m. when the precocious development of transferred fetuses had been taken into account [6].

High impact information on triamcinolone


Chemical compound and disease context of triamcinolone


Biological context of triamcinolone


Anatomical context of triamcinolone

  • In conclusion, triamcinolone induced type IIb fiber atrophy, resulting in reduced respiratory muscle strength and a leftward shift of the force-frequency curve [21].
  • The use of intraarticular triamcinolone hexacetonide in the management of persistent arthritis of the knee joint that is unresponsive to nonsteroidal anti-inflammatory drugs was prospectively evaluated in 40 children with chronic arthritis [22].
  • The amount bound in microsomes from triamcinolone-treated rats is significantly lower from the values for the other three physiological states, which do not differ significantly from each other [23].
  • Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage [24].
  • METHODS: Twenty-three children ages 4-16 years with JIA and MRI evidence of TMJ inflammation received CT-guided TMJ injections of corticosteroid (triamcinolone acetonide [n = 16] or triamcinolone hexacetonide [n = 7]) [25].

Associations of triamcinolone with other chemical compounds


Gene context of triamcinolone


Analytical, diagnostic and therapeutic context of triamcinolone


  1. Effect of triamcinolone acetonide on tyrosinase activity in a human melanoma cell line. DiSorbo, D.M., Harris, N.A., Nathanson, L. Cancer Res. (1984) [Pubmed]
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  3. Immediate "steroid flare" from intraarticular triamcinolone hexacetonide injection: case report and review of the literature. Berger, R.G., Yount, W.J. Arthritis Rheum. (1990) [Pubmed]
  4. Relative ineffectiveness of triamcinolone acetonide in the treatment of juvenile idiopathic arthritis. Alsufyani, K., Ortiz-Alvarez, O., Cabral, D.A., Tucker, L.B., Petty, R.E., Malleson, P.N. Arthritis Rheum. (2004) [Pubmed]
  5. Use of triamcinolone hexacetonide for the treatment of osteoarthritis of the hip: comment on the letter by Margules. Kahn, C. Arthritis Rheum. (2002) [Pubmed]
  6. Agent-determined type of maternal influence on induced cleft palate in mice. Larsson, K.S., Marsk, L., Svanberg-Larsson, A., Tesh, J.M. Biol. Neonate (1977) [Pubmed]
  7. Inhaled triamcinolone and chronic obstructive pulmonary disease. De Maria, A., Canonica, G.W. N. Engl. J. Med. (2001) [Pubmed]
  8. High-dose intramuscular triamcinolone in severe, chronic, life-threatening asthma. Ogirala, R.G., Aldrich, T.K., Prezant, D.J., Sinnett, M.J., Enden, J.B., Williams, M.H. N. Engl. J. Med. (1991) [Pubmed]
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  10. Triamcinolone aerosol. Treatment of aspirin-hypersensitive asthmatic patients. Pingleton, W.W., Bone, R.C., Kerby, G.R., Ruth, W.E. JAMA (1977) [Pubmed]
  11. SDF-1 is both necessary and sufficient to promote proliferative retinopathy. Butler, J.M., Guthrie, S.M., Koc, M., Afzal, A., Caballero, S., Brooks, H.L., Mames, R.N., Segal, M.S., Grant, M.B., Scott, E.W. J. Clin. Invest. (2005) [Pubmed]
  12. Retinoic acid and glucocorticoids enhance the effect of 1,25-dihydroxyvitamin D3 on bone gamma-carboxyglutamic acid protein synthesis by rat osteosarcoma cells. Nishimoto, S.K., Salka, C., Nimni, M.E. J. Bone Miner. Res. (1987) [Pubmed]
  13. Clinical effect of aerosol triamcinolone acetonide in bronchial asthma. Grieco, M.H., Dwek, J., Larsen, K., Rammohan, G. Arch. Intern. Med. (1978) [Pubmed]
  14. A comparison of triamcinolone acetonide nasal aerosol spray and fluticasone propionate aqueous solution spray in the treatment of spring allergic rhinitis. Small, P., Houle, P.A., Day, J.H., Briscoe, M., Gold, M., Brodarec, I., Ham Pong, A., Mandl, M., Spénard, J., Phillips, R., Furlan, M. J. Allergy Clin. Immunol. (1997) [Pubmed]
  15. HbA1c Values Determine the Outcome of Intrasheath Injection of Triamcinolone for Diabetic Flexor Tenosynovitis. Kameyama, M., Funae, O., Meguro, S., Atsumi, Y. Diabetes Care (2006) [Pubmed]
  16. Lumbar radiculopathy: treatment with selective lumbar nerve blocks--comparison of effectiveness of triamcinolone and betamethasone injectable suspensions. Blankenbaker, D.G., De Smet, A.A., Stanczak, J.D., Fine, J.P. Radiology. (2005) [Pubmed]
  17. DNA binding properties of glucocorticosteroid receptors bound to the steroid antagonist RU-486. Bourgeois, S., Pfahl, M., Baulieu, E.E. EMBO J. (1984) [Pubmed]
  18. Cough and wheezing from beclomethasone dipropionate aerosol are absent after triamcinolone acetonide. Shim, C.S., Williams, M.H. Ann. Intern. Med. (1987) [Pubmed]
  19. Membrane permeability as a determinant of dexamethasone resistance in murine thymoma cells. Johnson, D.M., Newby, R.F., Bourgeois, S. Cancer Res. (1984) [Pubmed]
  20. Suppression of DNA synthesis in NEL-M1 human melanoma cells by triamcinolone acetonide. DiSorbo, D.M., Harris, N.A., Nathanson, L. Cancer Res. (1985) [Pubmed]
  21. Triamcinolone and prednisolone affect contractile properties and histopathology of rat diaphragm differently. Dekhuijzen, P.N., Gayan-Ramirez, G., de Bock, V., Dom, R., Decramer, M. J. Clin. Invest. (1993) [Pubmed]
  22. Intraarticular triamcinolone hexacetonide in the management of chronic arthritis in children. Allen, R.C., Gross, K.R., Laxer, R.M., Malleson, P.N., Beauchamp, R.D., Petty, R.E. Arthritis Rheum. (1986) [Pubmed]
  23. Rat liver microsomal glucose-6-P translocase. Effect of physiological status on inhibition and labeling by stilbene disulfonic acid derivatives. Zoccoli, M.A., Hoopes, R.R., Karnovsky, M.L. J. Biol. Chem. (1982) [Pubmed]
  24. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Williams, J.M., Brandt, K.D. Arthritis Rheum. (1985) [Pubmed]
  25. Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritis. Arabshahi, B., Dewitt, E.M., Cahill, A.M., Kaye, R.D., Baskin, K.M., Towbin, R.B., Cron, R.Q. Arthritis Rheum. (2005) [Pubmed]
  26. Comparison of in vivo activation of triamcinolone acetonide- and RU 38486-receptor complexes in the CEM-C7 and IM-9 human leukemic cell lines. Schmidt, T.J. Cancer Res. (1989) [Pubmed]
  27. Glucocorticosteroid inhibition of nonphagocytic discharge of lysosomal enzymes from human neutrophils. Ignarro, L.J. Arthritis Rheum. (1977) [Pubmed]
  28. Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form. McIntyre, W.R., Samuels, H.H. J. Biol. Chem. (1985) [Pubmed]
  29. The development and application of a radioimmunoassay for rat phosphoenolpyruvate carboxykinase. Moore, R.E., Hansen, J.B., Lardy, H.A., Veneziale, C.M. J. Biol. Chem. (1982) [Pubmed]
  30. Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. Matsuda, S., Gomi, F., Oshima, Y., Tohyama, M., Tano, Y. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  31. Corticosteroids decrease mRNA levels of SERCA pumps, whereas they increase sarcolipin mRNA in the rat diaphragm. Gayan-Ramirez, G., Vanzeir, L., Wuytack, F., Decramer, M. J. Physiol. (Lond.) (2000) [Pubmed]
  32. Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6. Boden, S.D., Hair, G., Titus, L., Racine, M., McCuaig, K., Wozney, J.M., Nanes, M.S. Endocrinology (1997) [Pubmed]
  33. Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis. De Benedetti, F., Meazza, C., Vivarelli, M., Rossi, F., Pistorio, A., Lamb, R., Lunt, M., Thomson, W., Ravelli, A., Donn, R., Martini, A. Arthritis Rheum. (2003) [Pubmed]
  34. Glucocorticoid regulation of hepatic 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression. Marker, A.J., Colosia, A.D., Tauler, A., Solomon, D.H., Cayre, Y., Lange, A.J., el-Maghrabi, M.R., Pilkis, S.J. J. Biol. Chem. (1989) [Pubmed]
  35. Binding of the glucocorticoid receptor to the rat liver nuclear matrix. The role of disulfide bond formation. Kaufmann, S.H., Okret, S., Wikström, A.C., Gustafsson, J.A., Shaper, J.H. J. Biol. Chem. (1986) [Pubmed]
  36. Local steroids in dialysis-associated pericardial effusion. A single intrapericardial administration of triamcinolone. Quigg, R.J., Idelson, B.A., Yoburn, D.C., Hymes, J.L., Schick, E.C., Bernard, D.B. Arch. Intern. Med. (1985) [Pubmed]
  37. Systemic adverse effects of inhaled corticosteroid therapy: A systematic review and meta-analysis. Lipworth, B.J. Arch. Intern. Med. (1999) [Pubmed]
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