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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Diamine preparation for synthesis of a water soluble Ni(II) salen complex.

A reliable and efficient synthesis of a Ni(II) salen complex useful in probing nucleic acid structure is described and illustrates a general approach for constructing cis diamines suitable for assembly into N2O2 Schiff base complexes. Two equivalents of an aryllithium reacted with 1,4-dimethylpiperazine-2,3-dione to form the symmetric alpha-dione. This material was then converted to its dioxime and reduced by TiCl4/NaBH4 to yield the meso-diamine. Condensation of the diamine and salicyladehyde, coordination of nickel and final methylation generated the desired water soluble and redox active complex.[1]

References

  1. Diamine preparation for synthesis of a water soluble Ni(II) salen complex. Shearer, J.M., Rokita, S.E. Bioorg. Med. Chem. Lett. (1999) [Pubmed]
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