Disease relevance of SALICYLALDEHYDE

• We compared the effects of oil of basil (Ocimum basilicum) and essential oil components (thymol, carvacrol, and salicylaldehyde) to those of a placebo when placed in the ear canal of rats with experimental acute otitis media caused by pneumococci or Haemophilus influenzae [1].
• In vapour phase toxicity tests with female lice, benzaldehyde and salicylaldehyde were much more effective in closed containers than in open ones, indicating that the mode of delivery of these compounds was largely due to action in the vapour phase [2].
• Antiproliferative activities of iron and platinum conjugates of salicylaldehyde semi-/thiosemicarbazones against C6 glioma cells [3].
• The acetone and salicylaldehyde derivatives showed similar potency to (-) ephedrine in the hyperthermia model [4].
• A series of salicylaldehyde benzoylhydrazone derivatives, their copper(II) complexes and a range of transition metal complexes of the unsubstituted ligand has been synthesized and evaluated for cytotoxicity against a human adenocarcinoma cell line [5].

Psychiatry related information on SALICYLALDEHYDE

• 1. The four stereoisomeric ephedrines and four oxazolidines formed by reaction of each ephedrine isomer with salicylaldehyde were tested for their ability to increase locomotor activity in rats [6].

High impact information on SALICYLALDEHYDE

• The catabolization of the host-plant O-glucoside salicin into salicylaldehyde is a character state that evolved later in two distinct lineages, which specialized on Salicaceae [7].
• Other compounds (e.g., salicylaldehyde p-t-butyl-benzoyl hydrazone) redistributed ferritin-59Fe to different intracellular sites but had little net effect on hepatocyte iron levels [8].
• In human reticulocytes (unlike those from rabbits), addition of ferric salicylaldehyde isonicotinoylhydrazone, to increase the pre-heme iron pool independently of the transferrin cycle, failed to promote heme synthesis or modify feedback inhibition induced by hematin [9].
• Pyridoxal phosphate and salicylaldehyde were used as protein-labeling probes to study the organization of membrane proteins in the intact myelin sheath of the cat dorsal column [10].
• Organization of membrane proteins in the intact myelin sheath. Pyridoxal phosphate and salicylaldehyde as probes of myelin structure [10].

Chemical compound and disease context of SALICYLALDEHYDE

• Allergic contact dermatitis from salicyl alcohol and salicylaldehyde in aspen bark (Populus tremula) [11].
• A series of hydroxyguanidine derivatives, which are substituted salicylaldehyde Schiff-bases of 1-amino-3- hydroxyguanidine tosylate, were tested for the inhibition of RNA synthesis of mouse hepatitis virus (MHV) [12].
• Among of SA analogues, acetylsalicylic acid, salicylaldehyde, salicyl-alcohol, methyl salicylate and SA evoked a hypocalcemia in rats and mice but the other analogues had no effect by their single administration [13].
• The azomethine derivative formed from salicylaldehyde (5-ASASB3) was found to have maximum activity and it reversed the disease symptoms in experimental animals The azomethine derivative markedly reduces the ulcerative colitis when compared with parent molecule, mesalazine [14].

Biological context of SALICYLALDEHYDE

• Complexes of salicylaldehyde acylhydrazones: cytotoxicity, QSAR and crystal structure of the sterically hindered t-butyl dimer [15].
• A more efficient route to 7 involves concomitant salicylaldehyde Schiff base and 4,5-oxazolidine formation followed by mesylation and hydrolysis [16].
• The results showed that all of the compounds decreased food intake significantly, but only the acetone and the salicylaldehyde derivatives caused a significant elevation of body temperature [4].
• Condensation of the diamine and salicyladehyde, coordination of nickel and final methylation generated the desired water soluble and redox active complex [17].
• On the basis of the 50% lethal dose (LD50), the compound most toxic to T. putrescentiae adults was salicylaldehyde (LD50 of 1.02 microg/cm2) followed by cinnamaldehyde (1.66 microg/cm2), benzaldehyde (4.23 microg/cm2), phthaldialdehyde (5.16 microg/cm2), benzyl benzoate (9.75 microg/cm2), and N,N-diethyl-m-toluamide (16.26 micorg/cm2) [18].

Anatomical context of SALICYLALDEHYDE

• The relatively membrane-permeant probe, salicylaldehyde, was then used to establish that the basic protein is truly located on the cytoplasmic side of the myelin bilayer, and not merely sequestered within the multiple lamellar structure of the sheath [10].
• 1,2-Benzisoxazole was also reduced to salicylaldehyde by rabbit liver cytosol and aldehyde oxidase in the presence of 2-hydroxypyrimidine [19].
• Further studies on the antimicrobial activity of the salicylaldehyde-containing secretions of Chrysomela larvae revealed that they act nonspecifically against prokaryotic (Escherichia coli) and eukaryotic cells (Saccharomyces cerevisiae and Trichoplusia ni) [20].

Associations of SALICYLALDEHYDE with other chemical compounds

• [reaction: see text] A new fluorescent probe, salicylaldehyde rhodamine B hydrazone (1), was synthesized and displayed selective Cu(II)-amplified absorbance and fluorescence emission above 500 nm in neutral buffered media [21].
• The first exposure to the odors of carbon tetrachloride, isopentenyl methyl sulfide, methyl ethyl ketone, 2-propylthietane, salicylaldehyde, toluene, 2,4,5-trimethyl thiazoline, or xylene elicits a weakly developed 20 Hz wave response (beta-waves) in central olfactory structures in the rat [22].
• Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bulb and pyriform cortex [23].
• Single-crystal X-ray structure and spectroscopic characterizations of Cu(salEen)2(ClO4)2, are reported; salEen is a Schiff base condensation product of equimolar amounts of salicylaldehyde and N,N-diethylethylenediamine [24].
• The behavior in electrospray ionization mass spectrometry (ESI-MS) conditions of some complexes formed by Pb(C6H5)2(OAc)2 with salicylaldehyde, 2-ketobutyric acid, pyridine-2-carbaldehyde, 2-acetylpyridine, and 2-benzoylpyridine thiosemicarbazones, was studied in detail with the aid of collisional experiments performed by ion trap [25].

Gene context of SALICYLALDEHYDE

• These products, formed in equimolar amounts, were the only ones detected that suggests that FMO1 catalyzes the oxidation of salicylaldehyde by Baeyer-Villiger chemistry [26].
• EHT and CNDO calculations have been performed on a series on fungicidal salicylaldehyde derivatives [27].
• A series of new bis[N-(2,6-di-tert-butyl-1-hyxyphenyl)salicylideneminato]zinc(II) complexes bearing one or two HO- and CH3O-substituents on the salicylaldehyde moiety were prepared, and their spectroscopic properties (IR, electronic, 1H NMR) as well as the ESR spectra of the one-electron oxidation products were examined [28].

Analytical, diagnostic and therapeutic context of SALICYLALDEHYDE

• The strong coordination interaction between salicylaldehyde and copper acetate made the complex have high retention on the HPLC column based on the SAD-Cu(OAc)(2) imprinted polymer [29].
• Salicylaldehyde-metal-amino acid ternary complex: a new tool for immobilized metal affinity chromatography [30].
• Catalytic activity of the chymotrypsin salicylaldehyde conjugate was not changed upon the immobilization [31].
• Determination of desmethyl nortriptyline in plasma by gas chromatography before and after treatment with salicylaldehyde [32].

References