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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide.

BACKGROUND: Chronic hypercalciuria can contribute to osteoporosis, particularly in men. OBJECTIVE: To ascertain the effects of resolution of hypercalciuria on bone mineral density. DESIGN: Case series. SETTING: Referral service for metabolic bone disease in a tertiary-care teaching hospital. PATIENTS: Five male patients (42 to 66 years of age) with hypercalciuria and osteoporosis. INTERVENTION: Hydrochlorothiazide, 25 mg twice daily, for a mean (+/- SD) of 7.8 +/- 3.6 months. MEASUREMENTS: Fasting urinary calcium:creatinine ratio, serum calciotropic hormone levels, and bone mineral density before and after hydrochlorothiazide administration. RESULTS: Hydrochlorothiazide resolved hypercalciuria and increased bone mineral density at a rate of 8% and 3% per year at the spine and hip, respectively. CONCLUSIONS: Hydrochlorothiazide treatment in hypercalciuric and osteoporotic men was associated with a rapid rebound increase in bone mineral density.[1]

References

  1. Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide. Adams, J.S., Song, C.F., Kantorovich, V. Ann. Intern. Med. (1999) [Pubmed]
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