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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The bHLH gene Hes1 is essential for expansion of early T cell precursors.

Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arrested at the CD4(-)CD8(-) double negative (DN) stage. Both the initial T cell receptor (TCR)-independent and the subsequent TCR-dependent selective expansion during the DN stage are severely affected. Thus, Hes1 is essential for the earliest thymocyte expansion in a cell-autonomous manner.[1]

References

  1. The bHLH gene Hes1 is essential for expansion of early T cell precursors. Tomita, K., Hattori, M., Nakamura, E., Nakanishi, S., Minato, N., Kageyama, R. Genes Dev. (1999) [Pubmed]
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