Gene Review:
Hes1 - hairy and enhancer of split 1 (Drosophila)
Mus musculus
Synonyms:
Hairy and enhancer of split 1, Hes-1, Hry, Transcription factor HES-1, bHLHb39
- Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons. Hirata, H., Ohtsuka, T., Bessho, Y., Kageyama, R. J. Biol. Chem. (2000)
- Radiation-induced deletions in the 5' end region of Notch1 lead to the formation of truncated proteins and are involved in the development of mouse thymic lymphomas. Tsuji, H., Ishii-Ohba, H., Ukai, H., Katsube, T., Ogiu, T. Carcinogenesis (2003)
- Roles of the bHLH gene Hes1 in retinal morphogenesis. Takatsuka, K., Hatakeyama, J., Bessho, Y., Kageyama, R. Brain Res. (2004)
- Presence of presenilin 1/2 affects the invasion and replication of Salmonella typhimurium. Park, J.H., Kim, H.J., Choy, H.E., Kim, K. Biochem. Biophys. Res. Commun. (2005)
- Control of endodermal endocrine development by Hes-1. Jensen, J., Pedersen, E.E., Galante, P., Hald, J., Heller, R.S., Ishibashi, M., Kageyama, R., Guillemot, F., Serup, P., Madsen, O.D. Nat. Genet. (2000)
- The bHLH gene Hes1 is essential for expansion of early T cell precursors. Tomita, K., Hattori, M., Nakamura, E., Nakanishi, S., Minato, N., Kageyama, R. Genes Dev. (1999)
- Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Kamakura, S., Oishi, K., Yoshimatsu, T., Nakafuku, M., Masuyama, N., Gotoh, Y. Nat. Cell Biol. (2004)
- The role of notch signaling in the development of intrahepatic bile ducts. Kodama, Y., Hijikata, M., Kageyama, R., Shimotohno, K., Chiba, T. Gastroenterology (2004)
- Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Ito, T., Udaka, N., Yazawa, T., Okudela, K., Hayashi, H., Sudo, T., Guillemot, F., Kageyama, R., Kitamura, H. Development (2000)
- NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch. Salama-Cohen, P., Arévalo, M.A., Meier, J., Grantyn, R., Rodríguez-Tébar, A. Mol. Biol. Cell (2005)
- Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium. Bjerknes, M., Cheng, H. Dev. Biol. (2006)
- Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Mustonen, T., Tümmers, M., Mikami, T., Itoh, N., Zhang, N., Gridley, T., Thesleff, I. Dev. Biol. (2002)
- Hath1 up-regulates gastric mucin gene expression in gastric cells. Sekine, A., Akiyama, Y., Yanagihara, K., Yuasa, Y. Biochem. Biophys. Res. Commun. (2006)
- Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis. Piscione, T.D., Wu, M.Y., Quaggin, S.E. Gene Expr. Patterns (2004)
- Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Murata, K., Hattori, M., Hirai, N., Shinozuka, Y., Hirata, H., Kageyama, R., Sakai, T., Minato, N. Mol. Cell. Biol. (2005)
- Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor. Searfoss, G.H., Jordan, W.H., Calligaro, D.O., Galbreath, E.J., Schirtzinger, L.M., Berridge, B.R., Gao, H., Higgins, M.A., May, P.C., Ryan, T.P. J. Biol. Chem. (2003)
- Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. Chojnacki, A., Shimazaki, T., Gregg, C., Weinmaster, G., Weiss, S. J. Neurosci. (2003)
- Hes genes regulate sequential stages of neurogenesis in the olfactory epithelium. Cau, E., Gradwohl, G., Casarosa, S., Kageyama, R., Guillemot, F. Development (2000)
- Polycomb group gene mel-18 regulates early T progenitor expansion by maintaining the expression of Hes-1, a target of the Notch pathway. Miyazaki, M., Kawamoto, H., Kato, Y., Itoi, M., Miyazaki, K., Masuda, K., Tashiro, S., Ishihara, H., Igarashi, K., Amagai, T., Kanno, R., Kanno, M. J. Immunol. (2005)
- Segmental expression of Notch and Hairy genes in nephrogenesis. Chen, L., Al-Awqati, Q. Am. J. Physiol. Renal Physiol. (2005)
- Expression of Notch pathway components in fetal and adult mouse small intestine. Schröder, N., Gossler, A. Gene Expr. Patterns (2002)
- Overexpression of lunatic fringe does not affect epithelial cell differentiation in the developing mouse lung. van Tuyl, M., Groenman, F., Kuliszewski, M., Ridsdale, R., Wang, J., Tibboel, D., Post, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2005)
- A comparison of Notch, Hes and Grg expression during murine embryonic and post-natal development. Allen, T., Lobe, C.G. Cell. Mol. Biol. (Noisy-le-grand) (1999)
- Hes1 and Hes5 activities are required for the normal development of the hair cells in the mammalian inner ear. Zine, A., Aubert, A., Qiu, J., Therianos, S., Guillemot, F., Kageyama, R., de Ribaupierre, F. J. Neurosci. (2001)
- Hes1 is a negative regulator of inner ear hair cell differentiation. Zheng, J.L., Shou, J., Guillemot, F., Kageyama, R., Gao, W.Q. Development (2000)
- The vitamin D receptor, Runx2, and the Notch signaling pathway cooperate in the transcriptional regulation of osteopontin. Shen, Q., Christakos, S. J. Biol. Chem. (2005)