Gene Review:
Rag2 - recombination activating gene 2
Mus musculus
Synonyms:
RAG-2, Rag-2, V(D)J recombination-activating protein 2
- Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Rao, V.P., Poutahidis, T., Ge, Z., Nambiar, P.R., Boussahmain, C., Wang, Y.Y., Horwitz, B.H., Fox, J.G., Erdman, S.E. Cancer Res. (2006)
- IL-4 exacerbates disease in a Th1 cell transfer model of colitis. Fort, M., Lesley, R., Davidson, N., Menon, S., Brombacher, F., Leach, M., Rennick, D. J. Immunol. (2001)
- Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice. Barreto, V., Marques, R., Demengeot, J. Eur. J. Immunol. (2001)
- Immunologic and histopathologic characterization of an active disease mouse model for pemphigus vulgaris. Ohyama, M., Amagai, M., Tsunoda, K., Ota, T., Koyasu, S., Hata, J., Umezawa, A., Nishikawa, T. J. Invest. Dermatol. (2002)
- Polyethylene and titanium particles induce osteolysis by similar, lymphocyte-independent, mechanisms. Taki, N., Tatro, J.M., Nalepka, J.L., Togawa, D., Goldberg, V.M., Rimnac, C.M., Greenfield, E.M. J. Orthop. Res. (2005)
- Resting small B cells present endogenous immunoglobulin variable-region determinants to idiotope-specific CD4(+) T cells in vivo. Munthe, L.A., Kyte, J.A., Bogen, B. Eur. J. Immunol. (1999)
- Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Rideout, W.M., Hochedlinger, K., Kyba, M., Daley, G.Q., Jaenisch, R. Cell (2002)
- RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination. Agrawal, A., Schatz, D.G. Cell (1997)
- RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Shinkai, Y., Rathbun, G., Lam, K.P., Oltz, E.M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M. Cell (1992)
- B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. Hou, L., Sasakj, H., Stashenko, P. Infect. Immun. (2000)
- Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Sánchez, C., de Ceballos, M.L., del Pulgar, T.G., Rueda, D., Corbacho, C., Velasco, G., Galve-Roperh, I., Huffman, J.W., Ramón y Cajal, S., Guzmán, M. Cancer Res. (2001)
- Role of the complement-lectin pathway in anaphylactoid reaction induced with lipopolysaccharide in mice. Swierzko, A.S., Cedzyński, M., Kirikae, T., Nakano, M., Klink, M., Kirikae, F., Ziółkowski, A., Vinogradov, E.V., Kawakami, M. Eur. J. Immunol. (2003)
- Role of drug release and liposome-mediated drug delivery in governing the therapeutic activity of liposomal mitoxantrone used to treat human A431 and LS180 solid tumors. Lim, H.J., Masin, D., McIntosh, N.L., Madden, T.D., Bally, M.B. J. Pharmacol. Exp. Ther. (2000)
- Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Kim, M.G., Chen, C., Lyu, M.S., Cho, E.G., Park, D., Kozak, C., Schwartz, R.H. Immunogenetics (1999)
- Interplay between RORgammat, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Xi, H., Schwartz, R., Engel, I., Murre, C., Kersh, G.J. Immunity (2006)
- Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608. Zhang, F., Thomas, L.R., Oltz, E.M., Aune, T.M. Nat. Immunol. (2006)
- Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components. Galler, G.R., Mundt, C., Parker, M., Pelanda, R., Mårtensson, I.L., Winkler, T.H. J. Exp. Med. (2004)
- Three lymphoid-specific factors account for all junctional diversity characteristic of somatic assembly of T-cell receptor and immunoglobulin genes. Kallenbach, S., Doyen, N., Fanton d'Andon, M., Rougeon, F. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Han, S., Zheng, B., Schatz, D.G., Spanopoulou, E., Kelsoe, G. Science (1996)
- Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes. Geiman, T.M., Muegge, K. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Milner, J.D., Ward, J.M., Keane-Myers, A., Paul, W.E. Proc. Natl. Acad. Sci. U.S.A. (2007)
- Monitoring the effect of gene silencing by RNA interference in human CD34+ cells injected into newborn RAG2-/- gammac-/- mice: functional inactivation of p53 in developing T cells. Gimeno, R., Weijer, K., Voordouw, A., Uittenbogaart, C.H., Legrand, N., Alves, N.L., Wijnands, E., Blom, B., Spits, H. Blood (2004)
- Cyclophilin A-deficient mice are resistant to immunosuppression by cyclosporine. Colgan, J., Asmal, M., Yu, B., Luban, J. J. Immunol. (2005)
- The atheroprotective effect of 17beta-estradiol depends on complex interactions in adaptive immunity. Elhage, R., Gourdy, P., Jawien, J., Brouchet, L., Castano, C., Fievet, C., Hansson, G.K., Arnal, J.F., Bayard, F. Am. J. Pathol. (2005)
- The ontogeny of B cells in the thymus of normal, CD3 epsilon knockout (KO), RAG-2 KO and IL-7 transgenic mice. Ceredig, R. Int. Immunol. (2002)
- Bruton's tyrosine kinase is required for signaling the CD79b-mediated pro-B to pre-B cell transition. Kouro, T., Nagata, K., Takaki, S., Nisitani, S., Hirano, M., Wahl, M.I., Witte, O.N., Karasuyama, H., Takatsu, K. Int. Immunol. (2001)
- RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. Casillas, A.M., Thompson, A.D., Cheshier, S., Hernandez, S., Aguilera, R.J. Mol. Immunol. (1995)
- A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R., Desiderio, S. Immunity (2007)
- Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors. Miranda, G.A., Villalvazo, M., Galic, Z., Alva, J., Abrines, R., Yates, Y., Evans, C.J., Aguilera, R.J. Mol. Immunol. (2002)
- Identification of two catalytic residues in RAG1 that define a single active site within the RAG1/RAG2 protein complex. Fugmann, S.D., Villey, I.J., Ptaszek, L.M., Schatz, D.G. Mol. Cell (2000)
- RAG2 is down-regulated by cytoplasmic sequestration and ubiquitin-dependent degradation. Mizuta, R., Mizuta, M., Araki, S., Kitamura, D. J. Biol. Chem. (2002)
- RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Chen, J., Lansford, R., Stewart, V., Young, F., Alt, F.W. Proc. Natl. Acad. Sci. U.S.A. (1993)
- A mouse model of pemphigus vulgaris by adoptive transfer of naive splenocytes from desmoglein 3 knockout mice. Aoki-Ota, M., Tsunoda, K., Ota, T., Iwasaki, T., Koyasu, S., Amagai, M., Nishikawa, T. Br. J. Dermatol. (2004)
- Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. Xiao, H., Heeringa, P., Hu, P., Liu, Z., Zhao, M., Aratani, Y., Maeda, N., Falk, R.J., Jennette, J.C. J. Clin. Invest. (2002)
- Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responses. Barner, M., Mohrs, M., Brombacher, F., Kopf, M. Curr. Biol. (1998)
- Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T.K., Mendelsohn, M., Rolink, A., Melchers, F., Alt, F.W. Genes Dev. (1994)
- The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Chun, J.J., Schatz, D.G., Oettinger, M.A., Jaenisch, R., Baltimore, D. Cell (1991)
- Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. Cariappa, A., Liou, H.C., Horwitz, B.H., Pillai, S. J. Exp. Med. (2000)
- Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice. Petiniot, L.K., Weaver, Z., Barlow, C., Shen, R., Eckhaus, M., Steinberg, S.M., Ried, T., Wynshaw-Boris, A., Hodes, R.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Castigli, E., Alt, F.W., Davidson, L., Bottaro, A., Mizoguchi, E., Bhan, A.K., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Lineage-specific regulation of the murine RAG-2 promoter: GATA-3 in T cells and Pax-5 in B cells. Kishi, H., Wei, X.C., Jin, Z.X., Fujishiro, Y., Nagata, T., Matsuda, T., Muraguchi, A. Blood (2000)
- B cells can prime naive CD4+ T cells in vivo in the absence of other professional antigen-presenting cells in a CD154-CD40-dependent manner. Rodríguez-Pinto, D., Moreno, J. Eur. J. Immunol. (2005)
- A simple technique for generating probes for RNA in situ hybridization: an adjunct to genome mapping exemplified by the RAG-1/RAG-2 gene cluster. Boehm, T., Gonzalez-Sarmiento, R., Kennedy, M., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Gene therapy of RAG-2-/- mice: sustained correction of the immunodeficiency. Yates, F., Malassis-Séris, M., Stockholm, D., Bouneaud, C., Larousserie, F., Noguiez-Hellin, P., Danos, O., Kohn, D.B., Fischer, A., de Villartay, J.P., Cavazzana-Calvo, M. Blood (2002)
- Expression of the recombinase-activating gene (RAG-1) in murine early embryogenesis. Hayakawa, S., Tochigi, M., Chishima, F., Shiraishi, H., Takahashi, N., Watanabe, K., Fujii, K.T., Satoh, K. Immunol. Cell Biol. (1996)
- Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains. Kawamoto, H., Ohmura, K., Fujimoto, S., Lu, M., Ikawa, T., Katsura, Y. Eur. J. Immunol. (2003)