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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa.

The relationship between morphological changes and endotoxin release induced in vitro by carbapenems in a clinical isolate of Pseudomonas aeruginosa was examined. The time-course and magnitude of endotoxin release induced varied among imipenem, panipenem, meropenem and biapenem and related to the morphological changes caused by these agents which variously affected cell shape, cell-wall disintegration and cell lysis. The amount of endotoxin released by carbapenem-treated cells correlated with both the cell-wall morphology and bacterial shape immediately before lysis. Meropenem and biapenem caused markedly increased endotoxin release during cell lysis and cell-wall disintegration, whereas imipenem and panipenem caused much less release of endotoxin.[1]

References

  1. Relationship between morphological changes and endotoxin release induced by carbapenems in Pseudomonas aeruginosa. Horii, T., Ichiyama, S., Ohta, M., Kobayashi, M. J. Med. Microbiol. (1999) [Pubmed]
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