The "sins" of the fathers: self-healing squamous epithelioma in Scotland.
BACKGROUND: A review is presented of the recent progress made in mapping of the hereditary skin disease "Ferguson-Smith multiple self-healing squamous epithelioma." METHODS: The use of founder effects in an autosomal dominant disease is reviewed as applied to gene mapping efforts. RESULTS: A common haplotype among Scottish families segregating Ferguson-Smith disease allowed the narrowing of the candidate gene interval and the identification of several possible disease-associated genes. CONCLUSION: The gene for Ferguson-Smith multiple self-healing squamous epithelioma lies in a narrow region on chromosome 9q, along with several other important hereditary skin disease loci.[1]References
- The "sins" of the fathers: self-healing squamous epithelioma in Scotland. Bale, S.J. Journal of cutaneous medicine and surgery. (1999) [Pubmed]
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