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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Hozumi, I. et al.

Hozumi, Hiraiwa, Inuzuka, Yoneoka, Akiyama, Tanaka, Kikugawa, Nakano, Tsuji, O'Brien,

Administration of prosaposin ameliorates spatial learning disturbance and reduces cavity formation following stab wounds in rat brain.

The effectiveness of prosaposin as a neurotrophic factor was investigated using rats with bilateral stab wounds, injecting 240 ng per day of prosaposin for 3 days. In Morris water maze task, after 3 weeks postoperation, the stab-wounds rats show significant impairment in acquisition compared with the sham-operated rats. In the transfer test the mean number of crossings of the platform place in stab-wounds was significantly lower than that in sham-operated rats (P < 0.01). The stab-wounds rats treated with prosaposin showed significant improvement (P < 0.05). The cavities following stab wounds in the rats treated with prosaposin were significantly smaller than those in the rats treated with (P < 0.05). Our data support that prosaposin is likely to be a new agent for brain injury.[1]

References

Administration of prosaposin ameliorates spatial learning disturbance and reduces cavity formation following stab wounds in rat brain. Hozumi, I., Hiraiwa, M., Inuzuka, T., Yoneoka, Y., Akiyama, K., Tanaka, R., Kikugawa, K., Nakano, R., Tsuji, S., O'Brien, J.S. Neurosci. Lett. (1999) [Pubmed]

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