The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ntf3  -  neurotrophin 3

Rattus norvegicus

Synonyms: HDNF, NGF-2, NT-3, Nerve growth factor 2, Neurotrophic factor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ntf3

  • PNT-1 also promoted survival of a greater number of embryonic dorsal root ganglion neurons than any of the other neurotrophins alone, and its effects were equivalent to a combination of NGF, BDNF, and NT-3 [1].
  • BDNF and NT-3 decreased body weights, an effect that was sustained over the infusion period [2].
  • BDNF and NT-3 afforded neuronal protection even when administered 8 or 4 h, respectively, after the onset of hypoglycemia [3].
  • Epileptiform activity evoked by hippocampal stimulation and exceeding 70 s lead to a concomitant and transient increase of brain- derived neurotrophic factor, nerve growth factor, trkB and trkC messenger RNA expression in dentate granule cells after both focal and generalized seizures [4].
  • Endothelins play a role in the regulation of astrocytic functions in brain pathologies such as hyperplasia and neurotrophic factor production [5].

Psychiatry related information on Ntf3


High impact information on Ntf3


Chemical compound and disease context of Ntf3


Biological context of Ntf3


Anatomical context of Ntf3


Associations of Ntf3 with chemical compounds


Enzymatic interactions of Ntf3

  • In addition, NT-3 was able to phosphorylate the BDNF receptor, TrkB but only at higher concentration (50 ng/ml) [28].
  • However, we found the TrkC receptor constitutively phosphorylated even in the absence of added ligand suggesting an interaction of TrkC with endogenously produced NT-3 [28].
  • Tyrosine phosphorylation of the p13 Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target protein in response to bFGF was strongly inhibited by Shb overexpression, without correlating with the corresponding rate of neurite outgrowth [29].

Regulatory relationships of Ntf3

  • Exposure of immunoselected cells to NT-3 rapidly and transiently induced the appearance of nuclear Fos immunoreactivity [21].
  • BDNF- and NT-3-induced somatostatin release depended upon extra- and intracellular Ca(2+) since it was completely abolished in the presence of the Ca(2+) chelators BAPTA (bis-(alpha-aminophenoxy)-ethane-N,N,N',N'-tetraacetic acid) or BAPTA-AM (bis-(alpha-aminophenoxy)-ethane-N,N,N',N'-tetraacetoxymethylester), respectively [30].
  • These results suggest that endothelin is an extracellular signal that stimulates astrocytic neurotrophin-3 production in brain pathologies [5].
  • Taken together, these results suggest that NT3 induce NSCs to differentiate into OLPs by enhancing the expression of Olig-1 through an Erk1/2-dependent pathway [31].
  • BDNF and NT-3 stimulated neurite outgrowth of calbindin D neurons to a much smaller degree [32].

Other interactions of Ntf3

  • Neurotrophin-3: a neurotrophic factor related to NGF and BDNF [33].
  • The expression of NT-3 and NT-4 and their receptors in the trigeminal system prior to target field innervation suggests that these NTFs have also other functions than being the target-derived trophic factors [34].
  • Inhibitors of ERK activation that block inhibition by NGF had no effect on inhibition by NT-3 [35].
  • Transcripts coding for TrkC, the transducing receptor for NT-3, were identified in the fetal rat gut (E14-E16) and in the immunoselected population of cells using reverse transcriptase and the polymerase chain reaction [21].
  • BDNF and synapsin I mRNAs were lower and NT-3 levels were higher in the lumbar hemicord ipsilateral to the BTX-A injection [36].

Analytical, diagnostic and therapeutic context of Ntf3


  1. Pan-neurotrophin 1: a genetically engineered neurotrophic factor displaying multiple specificities in peripheral neurons in vitro and in vivo. Ilag, L.L., Curtis, R., Glass, D., Funakoshi, H., Tobkes, N.J., Ryan, T.E., Acheson, A., Lindsay, R.M., Persson, H., Yancopoulos, G.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  2. Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. Martin-Iverson, M.T., Todd, K.G., Altar, C.A. J. Neurosci. (1994) [Pubmed]
  3. Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Nakao, N., Kokaia, Z., Odin, P., Lindvall, O. Exp. Neurol. (1995) [Pubmed]
  4. Regulation of neurotrophin and trkA, trkB and trkC tyrosine kinase receptor messenger RNA expression in kindling. Bengzon, J., Kokaia, Z., Ernfors, P., Kokaia, M., Leanza, G., Nilsson, O.G., Persson, H., Lindvall, O. Neuroscience (1993) [Pubmed]
  5. Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes. Koyama, Y., Baba, A., Matsuda, T. Neuroscience (2005) [Pubmed]
  6. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease. Pérez-Navarro, E., Canudas, A.M., Akerund, P., Alberch, J., Arenas, E. J. Neurochem. (2000) [Pubmed]
  7. Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo. Arenas, E., Persson, H. Nature (1994) [Pubmed]
  8. BDNF and NT3 extend the critical period for developmental climbing fibre plasticity. Sherrard, R.M., Bower, A.J. Neuroreport (2001) [Pubmed]
  9. Endogenous neurotrophin-3 supports the survival of a subpopulation of sensory neurons in neonatal rat. Zhou, X.F., Cameron, D., Rush, R.A. Neuroscience (1998) [Pubmed]
  10. trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E., Valenzuela, D.M. Cell (1991) [Pubmed]
  11. The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines. Loeb, D.M., Maragos, J., Martin-Zanca, D., Chao, M.V., Parada, L.F., Greene, L.A. Cell (1991) [Pubmed]
  12. Functional regeneration of sensory axons into the adult spinal cord. Ramer, M.S., Priestley, J.V., McMahon, S.B. Nature (2000) [Pubmed]
  13. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. McDonald, J.W., Liu, X.Z., Qu, Y., Liu, S., Mickey, S.K., Turetsky, D., Gottlieb, D.I., Choi, D.W. Nat. Med. (1999) [Pubmed]
  14. Neurotrophin-3 upregulates NGF receptors in a central nervous system glial cell line. Spoerri, P.E., Romanello, S., Petrelli, L., Negro, A., Guidolin, D., Skaper, S.D. Neuroreport (1993) [Pubmed]
  15. Ras activation of a Rac1 exchange factor, Tiam1, mediates neurotrophin-3-induced Schwann cell migration. Yamauchi, J., Miyamoto, Y., Tanoue, A., Shooter, E.M., Chan, J.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  16. Hippocampal neurotrophin levels in a kainate model of temporal lobe epilepsy: a lack of correlation between brain-derived neurotrophic factor content and progression of aberrant dentate mossy fiber sprouting. Shetty, A.K., Zaman, V., Shetty, G.A. J. Neurochem. (2003) [Pubmed]
  17. Activation of MAPK and CREB by GM1 induces survival of RGCs in the retina with axotomized nerve. Choi, J.S., Kim, J.A., Joo, C.K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  18. Effect of dexamethasone on the expression of brain-derived neurotrophic factor and neurotrophin-3 messenger ribonucleic acids after forebrain ischemia in the rat. Yang, J.T., Chang, C.N., Lee, T.H., Hsu, J.C., Lin, T.N., Hsu, Y.H., Hsieh Wu, J. Crit. Care Med. (2002) [Pubmed]
  19. Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid. Rudge, J.S., Pasnikowski, E.M., Holst, P., Lindsay, R.M. J. Neurosci. (1995) [Pubmed]
  20. Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip, N.Y., Lindsay, R.M. J. Neurosci. (1994) [Pubmed]
  21. Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. Chalazonitis, A., Rothman, T.P., Chen, J., Lamballe, F., Barbacid, M., Gershon, M.D. J. Neurosci. (1994) [Pubmed]
  22. Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. Funakoshi, H., Frisén, J., Barbany, G., Timmusk, T., Zachrisson, O., Verge, V.M., Persson, H. J. Cell Biol. (1993) [Pubmed]
  23. Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Pirvola, U., Ylikoski, J., Palgi, J., Lehtonen, E., Arumäe, U., Saarma, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  24. Development of survival responsiveness to brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5, but not to nerve growth factor, in cultured motoneurons from chick embryo spinal cord. Becker, E., Soler, R.M., Yuste, V.J., Giné, E., Sanz-Rodríguez, C., Egea, J., Martín-Zanca, D., Comella, J.X. J. Neurosci. (1998) [Pubmed]
  25. Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development. Friedman, W.J., Ernfors, P., Persson, H. J. Neurosci. (1991) [Pubmed]
  26. Brain-derived neurotrophic factor increases neurotrophin-3 expression in cerebellar granule neurons. Leingärtner, A., Heisenberg, C.P., Kolbeck, R., Thoenen, H., Lindholm, D. J. Biol. Chem. (1994) [Pubmed]
  27. Neurotrophin-3 and brain-derived neurotrophic factor activate multiple signal transduction events but are not survival factors for hippocampal pyramidal neurons. Marsh, H.N., Palfrey, H.C. J. Neurochem. (1996) [Pubmed]
  28. Constitutive phosphorylation of TrkC receptors in cultured cerebellar granule neurons might be responsible for the inability of NT-3 to increase neuronal survival and to activate p21 Ras. Zirrgiebel, U., Lindholm, D. Neurochem. Res. (1996) [Pubmed]
  29. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells. Karlsson, T., Kullander, K., Welsh, M. Cell Growth Differ. (1998) [Pubmed]
  30. Rapid stimulatory effects of brain-derived neurotrophic factor and neurotrophin-3 on somatostatin release and intracellular calcium rise in primary hypothalamic cell cultures. Marmigère, F., Choby, C., Rage, F., Richard, S., Tapia-Arancibia, L. Neuroendocrinology (2001) [Pubmed]
  31. Erk1/2 but not PI3K pathway is required for neurotrophin 3-induced oligodendrocyte differentiation of post-natal neural stem cells. Hu, X., Jin, L., Feng, L. J. Neurochem. (2004) [Pubmed]
  32. Expression of c-Met in developing rat hippocampus: evidence for HGF as a neurotrophic factor for calbindin D-expressing neurons. Korhonen, L., Sjöholm, U., Takei, N., Kern, M.A., Schirmacher, P., Castrén, E., Lindholm, D. Eur. J. Neurosci. (2000) [Pubmed]
  33. Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip, N.Y., Furth, M.E., Lindsay, R.M., Yancopoulos, G.D. Science (1990) [Pubmed]
  34. Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth. Arumäe, U., Pirvola, U., Palgi, J., Kiema, T.R., Palm, K., Moshnyakov, M., Ylikoski, J., Saarma, M. J. Cell Biol. (1993) [Pubmed]
  35. Neurotrophin-3 inhibits HCO absorption via a cAMP-dependent pathway in renal thick ascending limb. Good, D.W., George, T. Am. J. Physiol., Cell Physiol. (2001) [Pubmed]
  36. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. Gómez-Pinilla, F., Ying, Z., Roy, R.R., Hodgson, J., Edgerton, V.R. J. Neurophysiol. (2004) [Pubmed]
  37. Effects of axotomy and intraocular administration of NT-4, NT-3, and brain-derived neurotrophic factor on the survival of adult rat retinal ganglion cells. A quantitative in vivo study. Peinado-Ramón, P., Salvador, M., Villegas-Pérez, M.P., Vidal-Sanz, M. Invest. Ophthalmol. Vis. Sci. (1996) [Pubmed]
  38. In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. Grider, M.H., Mamounas, L.A., Le, W., Shine, H.D. J. Neurosci. Res. (2005) [Pubmed]
WikiGenes - Universities