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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery.

The efficacy of antibiotic prophylaxis in cardiac surgery was compared between 97 patients receiving a single 2 g dosage of ceftriaxone and 103 receiving 500 mg of vancomycin i.v. every 6 h for 48 h. The overall infection rate was 13.4% in the ceftriaxone and 10.7% in the vancomycin group. Four (4%) wound infections, including one mediastinitis, occurred in the ceftriaxone group and five (5%) in the vancomycin group, with no statistically significant difference. The findings of this study support the adequacy of a simple single dose of ceftriaxone prophylaxis in cardiac surgery, at least in hospitals with low incidence of vancomycin-resistant staphylococcal infections.[1]

References

  1. Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery. Salminen, U.S., Viljanen, T.U., Valtonen, V.V., Ikonen, T.E., Sahlman, A.E., Harjula, A.L. J. Antimicrob. Chemother. (1999) [Pubmed]
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