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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery.

The efficacy of antibiotic prophylaxis in cardiac surgery was compared between 97 patients receiving a single 2 g dosage of ceftriaxone and 103 receiving 500 mg of vancomycin i.v. every 6 h for 48 h. The overall infection rate was 13.4% in the ceftriaxone and 10.7% in the vancomycin group. Four (4%) wound infections, including one mediastinitis, occurred in the ceftriaxone group and five (5%) in the vancomycin group, with no statistically significant difference. The findings of this study support the adequacy of a simple single dose of ceftriaxone prophylaxis in cardiac surgery, at least in hospitals with low incidence of vancomycin-resistant staphylococcal infections.[1]


  1. Ceftriaxone versus vancomycin prophylaxis in cardiovascular surgery. Salminen, U.S., Viljanen, T.U., Valtonen, V.V., Ikonen, T.E., Sahlman, A.E., Harjula, A.L. J. Antimicrob. Chemother. (1999) [Pubmed]
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