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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis.

Idiopathic inflammatory bowel disease is a chronic relapsing condition. The role of stress in causing relapses of inflammatory bowel disease remains controversial. We now show that colitis induced in mice by dinitrobenzenesulfonic acid (DNBS) resolves by 6 weeks, but can subsequently be reactivated by stress plus a sub-threshold dose of DNBS, but not by DNBS alone. Stress reduced colonic mucin and increased colon permeability. Susceptibility to reactivation by stress required CD4+ lymphocytes and could be adoptively transferred. We conclude that stress reactivates experimental colitis by facilitating entry of luminal contents that activate previously sensitized CD4 cells in the colon.[1]

References

  1. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Qiu, B.S., Vallance, B.A., Blennerhassett, P.A., Collins, S.M. Nat. Med. (1999) [Pubmed]
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