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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Retinopathy and attenuated circadian entrainment in Crx-deficient mice.

Crx, an Otx-like homeobox gene, is expressed specifically in the photoreceptors of the retina and the pinealocytes of the pineal gland. Crx has been proposed to have a role in the regulation of photoreceptor-specific genes in the eye and of pineal-specific genes in the pineal gland. Mutations in human CRX are associated with the retinal diseases, cone-rod dystrophy-2 (adCRD2; refs 3, 4, 5), retinitis pigmentosa ( RP) and Leber congenital amaurosis ( LCA), which all lead to loss of vision. We generated mice carrying a targeted disruption of Crx. Crx-/- mice do not elaborate photoreceptor outer segments and lacked rod and cone activity as assayed by electroretinogram (ERG). Expression of several photoreceptor- and pineal-specific genes was reduced in Crx mutants. Circadian entrainment was also affected in Crx-/- mice.[1]


  1. Retinopathy and attenuated circadian entrainment in Crx-deficient mice. Furukawa, T., Morrow, E.M., Li, T., Davis, F.C., Cepko, C.L. Nat. Genet. (1999) [Pubmed]
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