- Selective inhibition of protein kinase C, mitogen-activated protein kinase, and neutrophil activation in response to calcium pyrophosphate dihydrate crystals, formyl-methionyl-leucyl-phenylalanine, and phorbol ester by O-(chloroacetyl-carbamoyl) fumagillol (AGM-1470; TNP-470). Tudan, C., Jackson, J.K., Pelech, S.L., Attardo, G., Burt, H. Biochem. Pharmacol. (1999)