Gene Review:
PMAIP1 - phorbol-12-myristate-13-acetate-induced...
Homo sapiens
Synonyms:
APR, Immediate-early-response protein APR, NOXA, PMA-induced protein 1, Phorbol-12-myristate-13-acetate-induced protein 1, ...
Malakooti,
Sandoval,
Memark,
Dudeja,
Ramaswamy,
Jansson,
Emterling,
Arbman,
Sun,
Traore,
Trush,
George,
Spannhake,
Anderson,
Asseffa,
Yakovlev,
Di Giovanni,
Wang,
Liu,
Stoica,
Faden,
Konopka,
Düzgüneş,
Smalley,
Contractor,
Haass,
Kulp,
Atilla-Gokcumen,
Williams,
Bregman,
Flaherty,
Soengas,
Meggers,
Herlyn,
Yoshida,
Takemura,
Inoue,
Miyashita,
Ueda,
- BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. Kim, J.Y., Ahn, H.J., Ryu, J.H., Suk, K., Park, J.H. J. Exp. Med. (2004)
- Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection. Sun, Y., Leaman, D.W. J. Biol. Chem. (2005)
- Noxa in colorectal cancer: a study on DNA, mRNA and protein expression. Jansson, A.K., Emterling, A.M., Arbman, G., Sun, X.F. Oncogene (2003)
- Effect of exercise and food restriction on selected markers of the acute phase response in hamsters. Conn, C.A., Kozak, W.E., Tooten, P.C., Niewold, T.A., Borer, K.T., Kluger, M.J. J. Appl. Physiol. (1995)
- The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Black, P.H. Brain Behav. Immun. (2003)
- Expression of CD4 controls the susceptibility of THP-1 cells to infection by R5 and X4 HIV type 1 isolates. Konopka, K., Düzgüneş, N. AIDS Res. Hum. Retroviruses (2002)
- Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Eferl, R., Ricci, R., Kenner, L., Zenz, R., David, J.P., Rath, M., Wagner, E.F. Cell (2003)
- Chemical inducers of differentiation in Friend leukaemia cells inhibit lymphocyte mitogenesis. Stenzel, K.H., Schwartz, R., Rubin, A.L., Novogrodsky, A. Nature (1980)
- Life in the balance: how BH3-only proteins induce apoptosis. Willis, S.N., Adams, J.M. Curr. Opin. Cell Biol. (2005)
- Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Willis, S.N., Chen, L., Dewson, G., Wei, A., Naik, E., Fletcher, J.I., Adams, J.M., Huang, D.C. Genes Dev. (2005)
- Involvement of BH3-only proapoptotic proteins in mitochondrial-dependent Phenoxodiol-induced apoptosis of human melanoma cells. Yu, F., Watts, R.N., Zhang, X.D., Borrow, J.M., Hersey, P. Anticancer Drugs (2006)
- Enhanced Killing of Melanoma Cells by Simultaneously Targeting Mcl-1 and NOXA. Qin, J.Z., Xin, H., Sitailo, L.A., Denning, M.F., Nickoloff, B.J. Cancer Res. (2006)
- Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation. Ohta, H., Sweeney, E.A., Masamune, A., Yatomi, Y., Hakomori, S., Igarashi, Y. Cancer Res. (1995)
- BOK and NOXA are essential mediators of p53-dependent apoptosis. Yakovlev, A.G., Di Giovanni, S., Wang, G., Liu, W., Stoica, B., Faden, A.I. J. Biol. Chem. (2004)
- The molecular mechanism of Noxa-induced mitochondrial dysfunction in p53-mediated cell death. Seo, Y.W., Shin, J.N., Ko, K.H., Cha, J.H., Park, J.Y., Lee, B.R., Yun, C.W., Kim, Y.M., Seol, D.W., Kim, D.W., Yin, X.M., Kim, T.H. J. Biol. Chem. (2003)
- p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Qin, J.Z., Stennett, L., Bacon, P., Bodner, B., Hendrix, M.J., Seftor, R.E., Seftor, E.A., Margaryan, N.V., Pollock, P.M., Curtis, A., Trent, J.M., Bennett, F., Miele, L., Nickoloff, B.J. Mol. Cancer Ther. (2004)
- The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Pérez-Galán, P., Roué, G., Villamor, N., Montserrat, E., Campo, E., Colomer, D. Blood (2006)
- An Organometallic Protein Kinase Inhibitor Pharmacologically Activates p53 and Induces Apoptosis in Human Melanoma Cells. Smalley, K.S., Contractor, R., Haass, N.K., Kulp, A.N., Atilla-Gokcumen, G.E., Williams, D.S., Bregman, H., Flaherty, K.T., Soengas, M.S., Meggers, E., Herlyn, M. Cancer Res. (2007)
- E1A activates transcription of p73 and Noxa to induce apoptosis. Flinterman, M., Guelen, L., Ezzati-Nik, S., Killick, R., Melino, G., Tominaga, K., Mymryk, J.S., Gäken, J., Tavassoli, M. J. Biol. Chem. (2005)
- The Noxa/Mcl-1 axis regulates susceptibility to apoptosis under glucose limitation in dividing T cells. Alves, N.L., Derks, I.A., Berk, E., Spijker, R., van Lier, R.A., Eldering, E. Immunity (2006)
- Normoxic stabilization of hypoxia-inducible factor-1alpha by modulation of the labile iron pool in differentiating U937 macrophages: effect of natural resistance-associated macrophage protein 1. Knowles, H.J., Mole, D.R., Ratcliffe, P.J., Harris, A.L. Cancer Res. (2006)
- Nitric oxide inhibition of homocysteine-induced human endothelial cell apoptosis by down-regulation of p53-dependent Noxa expression through the formation of S-nitrosohomocysteine. Lee, S.J., Kim, K.M., Namkoong, S., Kim, C.K., Kang, Y.C., Lee, H., Ha, K.S., Han, J.A., Chung, H.T., Kwon, Y.G., Kim, Y.M. J. Biol. Chem. (2005)
- Tumor-promoting phorbol ester transiently down-modulates the p53 level and blocks the cell cycle. Skouv, J., Jensen, P.O., Forchhammer, J., Larsen, J.K., Lund, L.R. Cell Growth Differ. (1994)
- PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms. Hewson, C.A., Edbrooke, M.R., Johnston, S.L. J. Mol. Biol. (2004)
- Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis. Murakami, S., Shimabukuro, Y., Miki, Y., Saho, T., Hino, E., Kasai, D., Nozaki, T., Kusumoto, Y., Okada, H. J. Immunol. (1994)
- Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate. Malakooti, J., Sandoval, R., Memark, V.C., Dudeja, P.K., Ramaswamy, K. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Endotoxin-specific NF-kappaB activation in pulmonary epithelial cells harboring adenovirus E1A. Keicho, N., Higashimoto, Y., Bondy, G.P., Elliott, W.M., Hogg, J.C., Hayashi, S. Am. J. Physiol. (1999)
- Phorbol ester-induced down modulation of tailless CD4 receptors requires prior binding of gp120 and suggests a role for accessory molecules. Golding, H., Dimitrov, D.S., Manischewitz, J., Broder, C.C., Robinson, J., Fabian, S., Littman, D.R., Lapham, C.K. J. Virol. (1995)
- Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53. Li, J., Lee, B., Lee, A.S. J. Biol. Chem. (2006)
- Protein kinase Cdelta mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. Zhao, K.W., Li, X., Zhao, Q., Huang, Y., Li, D., Peng, Z.G., Shen, W.Z., Zhao, J., Zhou, Q., Chen, Z., Sims, P.J., Wiedmer, T., Chen, G.Q. Blood (2004)
- Translocation t(14;18) and gain of chromosome 18/BCL2: effects on BCL2 expression and apoptosis in B-cell non-Hodgkin's lymphomas. Galteland, E., Sivertsen, E.A., Svendsrud, D.H., Smedshammer, L., Kresse, S.H., Meza-Zepeda, L.A., Myklebost, O., Suo, Z., Mu, D., Deangelis, P.M., Stokke, T. Leukemia (2005)
- Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Kim, H., Rafiuddin-Shah, M., Tu, H.C., Jeffers, J.R., Zambetti, G.P., Hsieh, J.J., Cheng, E.H. Nat. Cell Biol. (2006)
- Endoplasmic reticulum BIK initiates DRP1-regulated remodelling of mitochondrial cristae during apoptosis. Germain, M., Mathai, J.P., McBride, H.M., Shore, G.C. EMBO J. (2005)
- Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway. Yoshida, A., Takemura, H., Inoue, H., Miyashita, T., Ueda, T. Cancer Res. (2006)
- Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent. Traore, K., Trush, M.A., George, M., Spannhake, E.W., Anderson, W., Asseffa, A. Leuk. Res. (2005)
- MG132 induced apoptosis is associated with p53-independent induction of pro-apoptotic Noxa and transcriptional activity of beta-catenin. Jüllig, M., Zhang, W.V., Ferreira, A., Stott, N.S. Apoptosis (2006)
- Mild hypothermia diminishes oxidative DNA damage and pro-death signaling events after cerebral ischemia: a mechanism for neuroprotection. Ji, X., Luo, Y., Ling, F., Stetler, R.A., Lan, J., Cao, G., Chen, J. Front. Biosci. (2007)