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Chemical Compound Review: 

Fumagillol     5-methoxy-4-[(2R)-2-methyl-3- (3-methylbut...

Synonyms: 108102-51-8
 
 
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Disease relevance of Fumagillol

 

High impact information on Fumagillol

  • Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes [5].
  • Selective inhibition of protein kinase C, mitogen-activated protein kinase, and neutrophil activation in response to calcium pyrophosphate dihydrate crystals, formyl-methionyl-leucyl-phenylalanine, and phorbol ester by O-(chloroacetyl-carbamoyl) fumagillol (AGM-1470; TNP-470) [6].
  • In this study, we investigated the effects of an antiangiogenic agent AGM-1470 (O-[chloroacetyl-carbamoyl] fumagillol: AGM) on the thickness of AIH after expanded polytetrafluoroethylene grafting [7].
  • The anti-tumor and anti-metastatic effects of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470), an angiogenesis inhibitor, and cisplatin (CDDP), an anti-neoplastic agent, were investigated using our established liver-metastasizing pancreatic carcinoma line, HPC-3H4 [8].
  • Novel cyclopentane analogues of fumagillol were synthesized and their endothelial cell proliferation inhibitory activities were evaluated [9].
 

Chemical compound and disease context of Fumagillol

  • The inhibition effects of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470), an angiogenesis inhibitor, and gemcitabine, a chemotherapeutic agent, on expression of growth factors were investigated using human pulmonary adenocarcinoma cell line, A549 [10].
 

Biological context of Fumagillol

References

  1. Frequent administration of angiogenesis inhibitor TNP-470 (AGM-1470) at an optimal biological dose inhibits tumor growth and metastasis of metastatic human transitional cell carcinoma in the urinary bladder. Inoue, K., Chikazawa, M., Fukata, S., Yoshikawa, C., Shuin, T. Clin. Cancer Res. (2002) [Pubmed]
  2. Antitumor effects of angiogenesis inhibitor 0-(chloroacetyl-carbamoyl) fumagillol (TNP-470) against murine renal cell carcinoma. Fujioka, T., Hasegawa, M., Ogiu, K., Matsushita, Y., Sato, M., Kubo, T. J. Urol. (1996) [Pubmed]
  3. Phase I dose escalation pharmacokinetics of O-(chloroacetylcarbamoyl) fumagillol (TNP-470) and its metabolites in AIDS patients with Kaposi's sarcoma. Moore, J.D., Dezube, B.J., Gill, P., Zhou, X.J., Acosta, E.P., Sommadossi, J.P. Cancer Chemother. Pharmacol. (2000) [Pubmed]
  4. Inhibition of tumor growth and metastasis by angiogenesis inhibitor TNP-470 on breast cancer cell lines in vitro and in vivo. Singh, Y., Shikata, N., Kiyozuka, Y., Nambu, H., Morimoto, J., Kurebayashi, J., Hioki, K., Tsubura, A. Breast Cancer Res. Treat. (1997) [Pubmed]
  5. Disposition and metabolism of the angiogenic moderator O-(chloroacetyl-carbamoyl) fumagillol (TNP-470; AGM-1470) in human hepatocytes and tissue microsomes. Placidi, L., Cretton-Scott, E., de Sousa, G., Rahmani, R., Placidi, M., Sommadossi, J.P. Cancer Res. (1995) [Pubmed]
  6. Selective inhibition of protein kinase C, mitogen-activated protein kinase, and neutrophil activation in response to calcium pyrophosphate dihydrate crystals, formyl-methionyl-leucyl-phenylalanine, and phorbol ester by O-(chloroacetyl-carbamoyl) fumagillol (AGM-1470; TNP-470). Tudan, C., Jackson, J.K., Pelech, S.L., Attardo, G., Burt, H. Biochem. Pharmacol. (1999) [Pubmed]
  7. Topical application of antiangiogenic agent AGM-1470 suppresses anastomotic intimal hyperplasia after ePTFE grafting in a rabbit model. Shigematsu, K., Yasuhara, H., Shigematsu, H. Surgery (2001) [Pubmed]
  8. Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin. Shishido, T., Yasoshima, T., Denno, R., Mukaiya, M., Sato, N., Hirata, K. Jpn. J. Cancer Res. (1998) [Pubmed]
  9. Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol. Jeong, B.S., Choi, N.S., Ahn, S.K., Bae, H., Kim, H.S., Kim, D. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
  10. Inhibition of expression of vascular endothelial growth factor and its receptors in pulmonary adenocarcinoma cell by TNP-470 in combination with gemcitabine. Wang, X.F., Tu, L.F., Wang, L.H., Zhou, J.Y. Journal of Zhejiang University. Science. B. (2006) [Pubmed]
  11. Chemical modification of fumagillin. II. 6-Amino-6-deoxyfumagillol and its derivatives. Marui, S., Kishimoto, S. Chem. Pharm. Bull. (1992) [Pubmed]
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