- A C619Y mutation in the human androgen receptor causes inactivation and mislocalization of the receptor with concomitant sequestration of SRC-1 (steroid receptor coactivator 1). Nazareth, L.V., Stenoien, D.L., Bingman, W.E., James, A.J., Wu, C., Zhang, Y., Edwards, D.P., Mancini, M., Marcelli, M., Lamb, D.J., Weigel, N.L. Mol. Endocrinol. (1999)