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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Impaired feedback of gastric functions in carboxypeptidase E-deficient mice.

Carboxypeptidase E deficiency as seen in the fat/fat mice is associated with reduced antral somatostatin content but tripling of the progastrin product. Thus, fat/fat mice are able to maintain normal tissue concentrations of bioactive alpha-amidated gastrin in spite of grossly attenuated progastrin processing. After induction of achlorhydria, however, neither the amount of alpha-amidated gastrin nor the total progastrin product increased in the fat/fat mice. This is contrary to what is seen in wild-type mice. Furthermore, the synthesis of antral somatostatin and fundic chromogranin A is also abnormal. Hence the results suggest a breakdown in the feedback loop that regulates gastric acid secretion.[1]


  1. Impaired feedback of gastric functions in carboxypeptidase E-deficient mice. Friis-Hansen, L., Rehfeld, J.F. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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