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Gene Review

Chga  -  chromogranin A

Mus musculus

Synonyms: CgA, ChrA, Chromogranin-A
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Disease relevance of Chga


High impact information on Chga


Chemical compound and disease context of Chga

  • We conclude that secretory stimulation of pheochromocytoma cells also activates the biosynthesis of the major secreted protein (chromogranin A), that the activation is transcriptional, and that a small proximal domain, including the CRE box, is, at least in part, both necessary and sufficient to account for the positive response to nicotine [2].
  • A marked reduction in CGA expression occurred in pheochromocytomas induced by technical grade pentachlorophenol, compared to the other three chemicals and the spontaneously occurring tumors [7].

Biological context of Chga


Anatomical context of Chga


Associations of Chga with chemical compounds


Regulatory relationships of Chga


Other interactions of Chga

  • Analysis of the allele distribution in an interspecific mouse backcross by single-strand conformation polymorphism positioned the chromogranin A locus on Chromosome 12, between Igh-C and D12Pas1 [8].
  • Chromogranin A is an acidic protein, stored and released with catecholamines, and is overexpressed in genetic hypertension [8].
  • In each case (mouse, rat, and human), chromogranin A is in a conserved region with nearby markers including the immunoglobulin heavy chain locus [8].
  • To address the role of the Hoxa3 gene in parathyroid organogenesis, we examined the third pharyngeal pouch development by immunohistochemistry (IHC) using the secretory protein (SP)-1/chromogranin A antiserum, which recognizes the parathyroid from its initial formation onward [18].
  • After antisense PC1 induction, an approximately 66-kD chromogranin A NH2-terminal fragment as well as the parent chromogranin A molecule accumulated, while an approximately 50 kD NH2-terminal and an approximately 30 kD COOH-terminal fragment declined in abundance [15].

Analytical, diagnostic and therapeutic context of Chga


  1. Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules. Strub, J.M., Goumon, Y., Lugardon, K., Capon, C., Lopez, M., Moniatte, M., Van Dorsselaer, A., Aunis, D., Metz-Boutigue, M.H. J. Biol. Chem. (1996) [Pubmed]
  2. Stimulus-transcription coupling in pheochromocytoma cells. Promoter region-specific activation of chromogranin a biosynthesis. Tang, K., Wu, H., Mahata, S.K., Taupenot, L., Rozansky, D.J., Parmer, R.J., O'Connor, D.T. J. Biol. Chem. (1996) [Pubmed]
  3. Cleavage of chromogranin A N-terminal domain by plasmin provides a new mechanism for regulating cell adhesion. Colombo, B., Longhi, R., Marinzi, C., Magni, F., Cattaneo, A., Yoo, S.H., Curnis, F., Corti, A. J. Biol. Chem. (2002) [Pubmed]
  4. Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour. Curry, W.J., Shaw, C., Johnston, C.F., Thim, L., Buchanan, K.D. FEBS Lett. (1992) [Pubmed]
  5. Interferon-alpha inhibits chromogranin A promoter activity in neuroendocrine pancreatic cancer cells. Plath, T., Höcker, M., Riecken, E.O., Wang, T.C., Wiedenmann, B., Rosewicz, S. FEBS Lett. (1999) [Pubmed]
  6. Chromogranin A, an "on/off" switch controlling dense-core secretory granule biogenesis. Kim, T., Tao-Cheng, J.H., Eiden, L.E., Loh, Y.P. Cell (2001) [Pubmed]
  7. A comparative immunohistochemical study of spontaneous and chemically induced pheochromocytomas in B6C3F1 mice. Hill, G.D., Pace, V., Persohn, E., Bresser, C., Haseman, J.K., Tischler, A.S., Nyska, A. Endocr. Pathol. (2003) [Pubmed]
  8. Assignment of the chromogranin A (Chga) locus to homologous regions on mouse chromosome 12 and rat chromosome 6. Simon-Chazottes, D., Wu, H., Parmer, R.J., Rozansky, D.J., Szpirer, J., Levan, G., Kurtz, T.W., Szpirer, C., Guenet, J.L., O'Connor, D.T. Genomics (1993) [Pubmed]
  9. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. Wu, H., Rozansky, D.J., Webster, N.J., O'Connor, D.T. J. Clin. Invest. (1994) [Pubmed]
  10. Chromogranin B-induced secretory granule biogenesis: comparison with the similar role of chromogranin A. Huh, Y.H., Jeon, S.H., Yoo, S.H. J. Biol. Chem. (2003) [Pubmed]
  11. Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression. Wu, H.J., Rozansky, D.J., Parmer, R.J., Gill, B.M., O'Connor, D.T. J. Biol. Chem. (1991) [Pubmed]
  12. Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins. Hendy, G.N., Li, T., Girard, M., Feldstein, R.C., Mulay, S., Desjardins, R., Day, R., Karaplis, A.C., Tremblay, M.L., Canaff, L. Mol. Endocrinol. (2006) [Pubmed]
  13. Role of nuclear chromogranin B in inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ mobilization. Huh, Y.H., Chu, S.Y., Park, S.Y., Huh, S.K., Yoo, S.H. Biochemistry (2006) [Pubmed]
  14. Chromogranin A deficiency in transgenic mice leads to aberrant chromaffin granule biogenesis. Kim, T., Zhang, C.F., Sun, Z., Wu, H., Loh, Y.P. J. Neurosci. (2005) [Pubmed]
  15. Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway. Eskeland, N.L., Zhou, A., Dinh, T.Q., Wu, H., Parmer, R.J., Mains, R.E., O'Connor, D.T. J. Clin. Invest. (1996) [Pubmed]
  16. The human chromogranin A gene: chromosome assignment and RFLP analysis. Modi, W.S., Levine, M.A., Seuanez, H.N., Dean, M., O'Brien, S.J. Am. J. Hum. Genet. (1989) [Pubmed]
  17. Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP). Taupenot, L., Mahata, S.K., Wu, H., O'Connor, D.T. J. Clin. Invest. (1998) [Pubmed]
  18. The role of Hoxa3 gene in parathyroid gland organogenesis of the mouse. Kameda, Y., Arai, Y., Nishimaki, T., Chisaka, O. J. Histochem. Cytochem. (2004) [Pubmed]
  19. Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype. Malosio, M.L., Giordano, T., Laslop, A., Meldolesi, J. J. Cell. Sci. (2004) [Pubmed]
  20. Growth and characterization of a cell line from a human primary neuroendocrine carcinoma of the skin (Merkel cell carcinoma) in culture and as xenograft. Krasagakis, K., Almond-Roesler, B., Geilen, C., Fimmel, S., Krengel, S., Chatzaki, E., Gravanis, A., Orfanos, C.E. J. Cell. Physiol. (2001) [Pubmed]
  21. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. Wu, H., Mahata, S.K., Mahata, M., Webster, N.J., Parmer, R.J., O'Connor, D.T. J. Clin. Invest. (1995) [Pubmed]
  22. Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression. Mouland, A.J., Bevan, S., White, J.H., Hendy, G.N. J. Biol. Chem. (1994) [Pubmed]
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