The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Achlorhydria


High impact information on Achlorhydria


Chemical compound and disease context of Achlorhydria


Biological context of Achlorhydria

  • The results suggest that in drug-induced achlorhydria, the progressive increase of enterochromaffinlike cells is explained by an enhanced mitosis, whereas other factors in addition to proliferation are responsible for the augmentation of gastrin cells [12].
  • This suggests that CYP2C19 genotype testing will not be useful in proton-pump inhibitor therapy of GERD, except perhaps in identifying patients at risk for hypochlorhydria and consequent hypergastrinemia [13].
  • In twelve patients with achlorhydria with a spared antrum, PCA was positive and basal gastrin was elevated [14].
  • Since hypochlorhydria can induce hypergastrinemia, and gastrin has a trophic effect on some gastrointestinal cells, states that cause elevated plasma gastrin levels are of interest in terms of effects on cell growth and function [15].

Anatomical context of Achlorhydria


Gene context of Achlorhydria


Analytical, diagnostic and therapeutic context of Achlorhydria


  1. Epidemic gastritis with hypochlorhydria. Ramsey, E.J., Carey, K.V., Peterson, W.L., Jackson, J.J., Murphy, F.K., Read, N.W., Taylor, K.B., Trier, J.S., Fordtran, J.S. Gastroenterology (1979) [Pubmed]
  2. Circulating gastrin, endocrine cells, histamine content, and histidine decarboxylase activity in atrophic gastritis. Cattan, D., Roucayrol, A.M., Launay, J.M., Callebert, J., Charasz, N., Nurit, Y., Belaiche, J., Kalifat, R. Gastroenterology (1989) [Pubmed]
  3. Rapid regression of enterochromaffinlike cell gastric carcinoids in pernicious anemia after antrectomy. Hirschowitz, B.I., Griffith, J., Pellegrin, D., Cummings, O.W. Gastroenterology (1992) [Pubmed]
  4. Postbulbar duodenal ulcer in a patient with pentagastrin-fast achlorhydria. Goldschmiedt, M., Peterson, W.L., Vuitch, F., Feldman, M. Gastroenterology (1989) [Pubmed]
  5. Treatment of malignant endocrine pancreatic tumours with human leucocyte interferon. Eriksson, B., Oberg, K., Alm, G., Karlsson, A., Lundqvist, G., Andersson, T., Wilander, E., Wide, L. Lancet (1986) [Pubmed]
  6. Calcium absorption and achlorhydria. Recker, R.R. N. Engl. J. Med. (1985) [Pubmed]
  7. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. Brand, S.J., Stone, D. J. Clin. Invest. (1988) [Pubmed]
  8. Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Zavros, Y., Rieder, G., Ferguson, A., Samuelson, L.C., Merchant, J.L. Gastroenterology (2002) [Pubmed]
  9. Helicobacter pylori and gastric acid: biological and therapeutic implications. McGowan, C.C., Cover, T.L., Blaser, M.J. Gastroenterology (1996) [Pubmed]
  10. Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet. Muscroft, T.J., Youngs, D.J., Burdon, D.W., Keighley, M.R. Lancet (1981) [Pubmed]
  11. Ascorbic acid in the human stomach. Sobala, G.M., Schorah, C.J., Sanderson, M., Dixon, M.F., Tompkins, D.S., Godwin, P., Axon, A.T. Gastroenterology (1989) [Pubmed]
  12. Proliferation of endocrine cells in the rat stomach caused by drug-induced achlorhydria. Eissele, R., Rosskopf, B., Koop, H., Adler, G., Arnold, R. Gastroenterology (1991) [Pubmed]
  13. CYP2C19 pharmacogenetics in the clinical use of proton-pump inhibitors for gastro-oesophageal reflux disease: variant alleles predict gastric acid suppression, but not oesophageal acid exposure or reflux symptoms. Egan, L.J., Myhre, G.M., Mays, D.C., Dierkhising, R.A., Kammer, P.P., Murray, J.A. Aliment. Pharmacol. Ther. (2003) [Pubmed]
  14. Parietal cell autoantibodies and hypergastrinemia in achlorhydria and the Zollinger-Ellison syndrome. Turnipseed, W.D., Keith, L.M., Sparks, J. Am. J. Surg. (1979) [Pubmed]
  15. Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells. A review and analysis. Freston, J.W., Borch, K., Brand, S.J., Carlsson, E., Creutzfeldt, W., Håkanson, R., Olbe, L., Solcia, E., Walsh, J.H., Wolfe, M.M. Dig. Dis. Sci. (1995) [Pubmed]
  16. Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations. Sobala, G.M., Crabtree, J.E., Dixon, M.F., Schorah, C.J., Taylor, J.D., Rathbone, B.J., Heatley, R.V., Axon, A.T. Gut (1991) [Pubmed]
  17. Streptozocin-treated Verner-Morrison Syndrome: plasma vasoactive intestinal peptide and tumor responses. Gagel, R.F., Costanza, M.E., DeLellis, R.A., Norton, R.A., Bloom, S.R., Miller, H.H., Ucci, A., Nathanson, L. Arch. Intern. Med. (1976) [Pubmed]
  18. Gastrin-mediated effects of omeprazole on rat colon mucosa. Klingensmith, M.E., Neville, L.J., Delpire, E., Wolfe, M.M., Soybel, D.I. Surgery (1999) [Pubmed]
  19. Gastric as well as duodenal biopsies may be useful in the investigation of iron deficiency anaemia. Dickey, W., Kenny, B.D., McMillan, S.A., Porter, K.G., McConnell, J.B. Scand. J. Gastroenterol. (1997) [Pubmed]
  20. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. Rad, R., Prinz, C., Neu, B., Neuhofer, M., Zeitner, M., Voland, P., Becker, I., Schepp, W., Gerhard, M. J. Infect. Dis. (2003) [Pubmed]
  21. Screening for multiple endocrine neoplasia type 1 in patients with recognized pituitary adenoma. Andersen, H.O., Jørgensen, P.E., Bardram, L., Hilsted, L. Clin. Endocrinol. (Oxf) (1990) [Pubmed]
  22. Impaired feedback of gastric functions in carboxypeptidase E-deficient mice. Friis-Hansen, L., Rehfeld, J.F. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  23. Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria. Kuno, M., Sogabe, H., Ito, H., Matsuo, T., Satoh, Y., Motoyama, Y., Tanaka, H. Pancreas (1998) [Pubmed]
  24. Roles for transforming growth factor-alpha in gastric physiology and pathophysiology. Coffey, R.J., Romano, M., Polk, W.H., Dempsey, P.J. The Yale journal of biology and medicine. (1992) [Pubmed]
  25. Toxigenic Helicobacter pylori infection precedes gastric hypochlorhydria in cancer relatives, and H. pylori virulence evolves in these families. Argent, R.H., Thomas, R.J., Aviles-Jimenez, F., Letley, D.P., Limb, M.C., El-Omar, E.M., Atherton, J.C. Clin. Cancer Res. (2008) [Pubmed]
  26. Effect of 1-phenylpentanol on release of secretin and exocrine pancreatic secretion in dogs and humans. Chey, W.Y., Millikan, L., Lee, K.Y., Watanabe, S., Shiratori, K., Takeuchi, T. Gastroenterology (1983) [Pubmed]
  27. The effect of gastric achlorhydria on the urinary recovery of nitrate in man: relevance to urinary nitrate as a measure of dietary nitrate exposure. Packer, P.J., Van Acker, B., Reed, P.I., Haines, K., Thompson, M.H., Hill, M.J., Leach, S.A. Carcinogenesis (1990) [Pubmed]
  28. Evaluation of gastric acid secretion at endoscopy with a modified Congo red test. Tóth, E., Sjölund, K., Thorsson, O., Thorlacius, H. Gastrointest. Endosc. (2002) [Pubmed]
  29. Pentagastrin given during upper gastrointestinal endoscopy: a simple screening method for hypo- and achlorhydria. Andersen, J., Ström, M. Gastrointest. Endosc. (1992) [Pubmed]
  30. Is the gastrin response to secretin provocation a function of antral G-cell mass? Results in the hypergastrinemia of acid hyposecretion. Brady, C.E., Hyatt, J.R., Utts, S.J. J. Clin. Gastroenterol. (1989) [Pubmed]
WikiGenes - Universities