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MeSH Review

Gastric Acid

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Disease relevance of Gastric Acid


Psychiatry related information on Gastric Acid

  • The Japanese Mazindol study group investigated the action of an anorexiant, mazindol, and found that it reduced food intake by directly suppressing neurons in the lateral hypothalamus, inhibited gastric acid secretion, increased motor activity, decreased glucose absorption, and inhibited insulin secretion [6].
  • In addition to measurements of gastric acid secretion after fasting and following histamine provocation, psychological ratings (Hamilton Anxiety Rating Scale and Zung Self-Assessment Scale for Anxiety) were carried out [7].

High impact information on Gastric Acid

  • A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion [8].
  • The fractions from these six patients also reduced gastrin-stimulated [14C]aminopyrine uptake by gastric cells (an index of gastric acid secretory activity in vitro) by 50.2 +/- 8.4 per cent (mean +/- S.D.), as compared with 9.2 +/- 4.1 per cent for the controls [9].
  • In five patients ingestion of 80 mg of omeprazole inhibited gastric acid secretion by 26 to 100 per cent after 6 hours and by 76 to 100 per cent after 24 hours [10].
  • Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine [11].
  • Inhibition of meal-stimualted gastric acid secretion showed a significant relation to peak blood cimetidine concentration (r is equal to 0.76, P less than 0.01) [12].

Chemical compound and disease context of Gastric Acid


Biological context of Gastric Acid

  • These findings suggest a defect in autoregulation of gastrin release and gastric acid secretion at low pH in ulcer patients which may play a role in pathogenesis of this disease [18].
  • Taken together, these results suggest a physiologic role for TFF2 to promote mucosal healing through the stimulation of proliferation and downregulation of gastric acid secretion [19].
  • Intracisternal injection of calcitonin at 0.01 microgram inhibited gastric acid output by 90% in pylorus-ligated rats and suppressed gastric emptying of a liquid meal by 63%-94% in doses ranging from 0.01 to 5 micrograms [20].
  • Cytoprotection by prostaglandins is unrelated to the inhibition of gastric acid secretion since, (a) it is maximal at doses that have no effect on gastric secretion, and (b) anti-secretory compounds (cimetidine, methscopolamine bromide) and antacids are not cytoprotective [21].
  • Acutely administered caffeine modestly increases blood pressure, plasma catecholamine levels, plasma renin activity, serum free fatty acid levels, urine production, and gastric acid secretion [22].

Anatomical context of Gastric Acid


Associations of Gastric Acid with chemical compounds


Gene context of Gastric Acid


Analytical, diagnostic and therapeutic context of Gastric Acid


  1. Impaired proximal duodenal mucosal bicarbonate secretion in patients with duodenal ulcer. Isenberg, J.I., Selling, J.A., Hogan, D.L., Koss, M.A. N. Engl. J. Med. (1987) [Pubmed]
  2. Preclinical evaluation of an anti-autocrine growth factor monoclonal antibody for treatment of patients with small-cell lung cancer. Avis, I.L., Kovacs, T.O., Kasprzyk, P.G., Treston, A.M., Bartholomew, R., Walsh, J.H., Cuttitta, F., Mulshine, J.L. J. Natl. Cancer Inst. (1991) [Pubmed]
  3. An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium. Bo-Linn, G.W., Davis, G.R., Buddrus, D.J., Morawski, S.G., Santa Ana, C., Fordtran, J.S. J. Clin. Invest. (1984) [Pubmed]
  4. Continuous infusion of somatostatin evokes escape of gastric acid inhibition in the rat. Ekelund, M., Ekman, R., Håkanson, R., Sundler, F. Gastroenterology (1984) [Pubmed]
  5. Parenteral antisecretory drug therapy in patients with Zollinger-Ellison syndrome. Saeed, Z.A., Norton, J.A., Frank, W.O., Young, M.D., Maton, P.N., Gardner, J.D., Jensen, R.T. Gastroenterology (1989) [Pubmed]
  6. Clinical and basic aspects of an anorexiant, mazindol, as an antiobesity agent in Japan. Inoue, S., Egawa, M., Satoh, S., Saito, M., Suzuki, H., Kumahara, Y., Abe, M., Kumagai, A., Goto, Y., Shizume, K. Am. J. Clin. Nutr. (1992) [Pubmed]
  7. Ranitidine plus bromazepam in the treatment of duodenal ulcer: effect on gastric acid secretion. García-Oyola, E., Curioso, W.I. J. Int. Med. Res. (1989) [Pubmed]
  8. A tyrosine-based signal targets H/K-ATPase to a regulated compartment and is required for the cessation of gastric acid secretion. Courtois-Coutry, N., Roush, D., Rajendran, V., McCarthy, J.B., Geibel, J., Kashgarian, M., Caplan, M.J. Cell (1997) [Pubmed]
  9. Autoantibody to the gastrin receptor in pernicious anemia. de Aizpurua, H.J., Ungar, B., Toh, B.H. N. Engl. J. Med. (1985) [Pubmed]
  10. Omeprazole in Zollinger-Ellison syndrome. Effects of a single dose and of long-term treatment in patients resistant to histamine H2-receptor antagonists. Lambers, C.B., Lind, T., Moberg, S., Jansen, J.B., Olbe, L. N. Engl. J. Med. (1984) [Pubmed]
  11. Effect of low-dose propantheline on food-stimulated gastric acid secretion: comparison with an "optimal effective dose" and interaction with cimetidine. Feldman, M., Richardson, C.T., Peterson, W.L., Walsh, J.H., Fordtran, J.S. N. Engl. J. Med. (1977) [Pubmed]
  12. Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer. Henn, R.M., Isenberg, J.I., Maxwell, V., Sturdevant, R.A. N. Engl. J. Med. (1975) [Pubmed]
  13. Induction of duodenal ulcers in rats under water-immersion stress conditions. Influence of stress on gastric acid and duodenal alkaline secretion. Takeuchi, K., Furukawa, O., Okabe, S. Gastroenterology (1986) [Pubmed]
  14. Omeprazole: effective, convenient therapy for Zollinger-Ellison syndrome. McArthur, K.E., Collen, M.J., Maton, P.N., Cherner, J.A., Howard, J.M., Ciarleglio, C.A., Cornelius, M.J., Jensen, R.T., Gardner, J.D. Gastroenterology (1985) [Pubmed]
  15. Gastric acid hypersecretion in refractory gastroesophageal reflux disease. Collen, M.J., Lewis, J.H., Benjamin, S.B. Gastroenterology (1990) [Pubmed]
  16. Delayed healing of acetic acid-induced gastric ulcers in rats by indomethacin. Wang, J.Y., Yamasaki, S., Takeuchi, K., Okabe, S. Gastroenterology (1989) [Pubmed]
  17. Failure of a cytoprotective dose of arbaprostil to heal acute duodenal ulcers. Results of a multiclinic trial. Euler, A.R., Tytgat, G., Berenguer, J., Brunner, H., Wood, D.R., Lookabaugh, J.L., Phan, T.D. Gastroenterology (1987) [Pubmed]
  18. pH dependence of acid secretion and gastrin release in normal and ulcer subjects. Walsh, J.H., Richardson, C.T., Fordtran, J.S. J. Clin. Invest. (1975) [Pubmed]
  19. TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury. Farrell, J.J., Taupin, D., Koh, T.J., Chen, D., Zhao, C.M., Podolsky, D.K., Wang, T.C. J. Clin. Invest. (2002) [Pubmed]
  20. Central nervous system action of calcitonin to alter experimental gastric ulcers in rats. Taché, Y., Kolve, E., Maeda-Hagiwara, M., Kauffman, G.L. Gastroenterology (1988) [Pubmed]
  21. Cytoprotection by prostaglandins in rats. Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Robert, A., Nezamis, J.E., Lancaster, C., Hanchar, A.J. Gastroenterology (1979) [Pubmed]
  22. The health consequences of caffeine. Curatolo, P.W., Robertson, D. Ann. Intern. Med. (1983) [Pubmed]
  23. Gastric acid secretion and lower-esophageal-sphincter pressure in response to coffee and caffeine. Cohen, S., Booth, G.H. N. Engl. J. Med. (1975) [Pubmed]
  24. Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat. Ligumsky, M., Goto, Y., Debas, H., Yamada, T. Science (1983) [Pubmed]
  25. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. Brand, S.J., Stone, D. J. Clin. Invest. (1988) [Pubmed]
  26. Cellular bicarbonate protects rat duodenal mucosa from acid-induced injury. Akiba, Y., Furukawa, O., Guth, P.H., Engel, E., Nastaskin, I., Sassani, P., Dukkipatis, R., Pushkin, A., Kurtz, I., Kaunitz, J.D. J. Clin. Invest. (2001) [Pubmed]
  27. Characterization and development of cimetidine as a histamine H2-receptor antagonist. Brimblecombe, R.W., Duncan, W.A., Durant, G.J., Emmett, J.C., Ganellin, C.R., Leslie, G.B., Parsons, M.E. Gastroenterology (1978) [Pubmed]
  28. Thyrotropin-releasing hormone--CNS action to stimulate gastric acid secretion. Taché, Y., Vale, W., Brown, M. Nature (1980) [Pubmed]
  29. Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats. Tepperman, B.L., Evered, M.D. Science (1980) [Pubmed]
  30. Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems. Ackerman, S.H. Science (1982) [Pubmed]
  31. Intraventricular calcitonin inhibits gastric acid secretion. Morley, J.E., Levine, A.S., Silvis, S.E. Science (1981) [Pubmed]
  32. Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans. Schmidt, W.E., Schenk, S., Nustede, R., Holst, J.J., Fölsch, U.R., Creutzfeldt, W. Gastroenterology (1994) [Pubmed]
  33. Effect of cholecystokinin and secretin on somatostatin release from cultured antral cells. Buchan, A.M., Meloche, R.M., Kwok, Y.N., Kofod, H. Gastroenterology (1993) [Pubmed]
  34. Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Chen, D., Zhao, C.M., Håkanson, R., Samuelson, L.C., Rehfeld, J.F., Friis-Hansen, L. Gastroenterology (2004) [Pubmed]
  35. High basal gastric acid secretion in somatostatin receptor subtype 2 knockout mice. Martinez, V., Curi, A.P., Torkian, B., Schaeffer, J.M., Wilkinson, H.A., Walsh, J.H., Taché, Y. Gastroenterology (1998) [Pubmed]
  36. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Grahammer, F., Herling, A.W., Lang, H.J., Schmitt-Gräff, A., Wittekindt, O.H., Nitschke, R., Bleich, M., Barhanin, J., Warth, R. Gastroenterology (2001) [Pubmed]
  37. Intravenous infusion of L-isomers of phenylalanine and tryptophan stimulate gastric acid secretion at physiologic plasma concentrations in normal subjects and after parietal cell vagotomy. McArthur, K.E., Isenberg, J.I., Hogan, D.L., Dreier, S.J. J. Clin. Invest. (1983) [Pubmed]
  38. Increased sensitivity of gastric acid secretion to gastrin in cirrhotic patients with portacaval shunt. Lenz, H.J., Struck, T., Greten, H., Koss, M.A., Eysselein, V.E., Walsh, J.H., Isenberg, J.I. J. Clin. Invest. (1987) [Pubmed]
  39. Intracerebroventricular neuropeptide Y increases gastric and pancreatic secretion in the dog. Geoghegan, J.G., Lawson, D.C., Cheng, C.A., Opara, E., Taylor, I.L., Pappas, T.N. Gastroenterology (1993) [Pubmed]
  40. Valosin stimulates gastric and exocrine pancreatic secretion and inhibits fasting small intestinal myoelectric activity in the dog. Konturek, S.J., Schmidt, W.E., Mutt, V., Konturek, J.W., Creutzfeldt, W. Gastroenterology (1987) [Pubmed]
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