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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A spectroscopic study of the molecular interactions of harmane with pyrimidine and other diazines.

FTIR, UV-vis, steady state and time-resolved fluorescence measurements show that harmane (1-methyl-9H-pyrido/3,4-b/indole) interacts with pyrimidine and its isomers pyrazine and pyridazine in its ground and lowest singlet states. The mechanisms of interaction are dependent on both the structure of the diazine and the nature of the solvent. Thus, in a low polar solvent such as toluene, harmane forms ground state 1:1 hydrogen-bonded complexes with all the diazines. These complexes quench the fluorescence of harmane and diminish its fluorescence lifetime. Conversely, in buffered (pH 8.7) aqueous solutions, pyrimidine behaves differently from the other diazines. Thus, whereas pyrimidine only interacts with harmane in its ground state, pyrazine and pyridazine also interact in the excited state. The harmane-pyrimidine ground state interaction is an entropic controlled process. Therefore, we propose the formation of pi-pi stacked 1:1 complexes between these substrates. Association constants for the different types of complexes and quenching parameters are reported.[1]


  1. A spectroscopic study of the molecular interactions of harmane with pyrimidine and other diazines. Muñoz, M.A., Guardado, P., Galán, M., Carmona, C., Balón, M. Biophys. Chem. (2000) [Pubmed]
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