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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Busulfan clearance in renal failure and hemodialysis.

The impact of hemodialysis on the clearance of busulfan was determined in a patient with chronic renal failure undergoing autologous peripheral stem cell transplantation for non-Hodgkin's lymphoma. The extraction ratio for busulfan across the dialyzer was 0.530 +/- 0.026 at a blood flow of 400 ml/min, which corresponds to a hemodialysis clearance of 2.23 +/- 0.11 ml/min/kg body weight. Apparent oral clearance of busulfan without hemodialysis was 3.38 +/- 0.56 ml/min/kg. Thus, a 4 h hemodialysis session enhanced the apparent oral clearance of busulfan by 65%. We conclude that hemodialysis effectively removes busulfan from circulating blood, but a standard hemodialysis period (ie, 4 h) does not significantly alter busulfan exposure. Bone Marrow Transplantation(2000) 25, 201-203.[1]

References

  1. Busulfan clearance in renal failure and hemodialysis. Ullery, L.L., Gibbs, J.P., Ames, G.W., Senecal, F.M., Slattery, J.T. Bone Marrow Transplant. (2000) [Pubmed]
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