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Swainson, R. et al.

Swainson, Rogers, Sahakian, Summers, Polkey, Robbins,

Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication.

Three groups of patients with Parkinson's disease (PD) - mild, unmedicated ( UPD), mild, medicated ( MPD) and severe, medicated ( SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning.[1]

References

Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. Swainson, R., Rogers, R.D., Sahakian, B.J., Summers, B.A., Polkey, C.E., Robbins, T.W. Neuropsychologia. (2000) [Pubmed]

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