The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Discrimination Learning

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Discrimination Learning


Psychiatry related information on Discrimination Learning


High impact information on Discrimination Learning

  • The gamma2 +/- mice showed enhanced behavioral inhibition toward natural aversive stimuli and heightened responsiveness in trace fear conditioning and ambiguous cue discrimination learning [8].
  • The results show that chronic intraventricular infusion of the NMDA receptor antagonist D,L-2-amino-5-phosphonopentanoic acid (D,L-AP5) caused an impairment of spatial but not of visual discrimination learning in rats [9].
  • After this discrimination learning was accomplished in 3-5 days, the rats were anesthetized with urethane (1.5 g/kg, i.p.), and neural responses were recorded in SI during flutter stimuli applied to the contralateral hindpaw [10].
  • Haloperidol also produced greater facilitation and retention of discrimination learning in the laboratory [11].
  • This study examines the extent to which simultaneous olfactory discrimination learning increases spine density on hippocampal CA1 pyramidal neurons in C57BL/6J (C57) and DBA/2J (DBA) inbred mice, characterized by spontaneous differences in hippocampal plasticity and hippocampus-related learning [12].

Chemical compound and disease context of Discrimination Learning


Biological context of Discrimination Learning


Anatomical context of Discrimination Learning


Gene context of Discrimination Learning


Analytical, diagnostic and therapeutic context of Discrimination Learning


  1. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Hyde, L.A., Frisone, D.F., Crnic, L.S. Behav. Brain Res. (2001) [Pubmed]
  2. Effect of gestational undernutrition and chlordiazepoxide treatment on black/white discrimination learning and retention in young rats. Jaiswal, A.K., Bhattacharya, S.K. Indian J. Exp. Biol. (1994) [Pubmed]
  3. Prenatal monosodium glutamate (MSG) treatment given through the mother's diet causes behavioral deficits in rat offspring. Frieder, B., Grimm, V.E. Int. J. Neurosci. (1984) [Pubmed]
  4. Normal olfactory discrimination learning set and facilitation of reversal learning after medial-temporal damage in rats: implications for an account of preserved learning abilities in amnesia. Eichenbaum, H., Fagan, A., Cohen, N.J. J. Neurosci. (1986) [Pubmed]
  5. Effects of chronic manipulations of dietary choline on locomotor activity, discrimination learning and cortical acetylcholine release in aging adult Fisher 344 rats. Beninger, R.J., Tighe, S.A., Jhamandas, K. Neurobiol. Aging (1984) [Pubmed]
  6. An assessment of the interaction between cholecystokinin and the opiates within a drug discrimination procedure. Melton, P.M., Riley, A.L. Pharmacol. Biochem. Behav. (1993) [Pubmed]
  7. The effects of haloperidol on discrimination learning and behavioral symptoms in autistic children. Anderson, L.T., Campbell, M., Adams, P., Small, A.M., Perry, R., Shell, J. Journal of autism and developmental disorders. (1989) [Pubmed]
  8. Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues. Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J.P., Belzung, C., Fritschy, J.M., Lüscher, B., Mohler, H. Nat. Neurosci. (1999) [Pubmed]
  9. Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. Morris, R.G. J. Neurosci. (1989) [Pubmed]
  10. Endogenous fluorescence imaging of somatosensory cortical activities after discrimination learning in rats. Shibuki, K., Ono, K., Hishida, R., Kudoh, M. Neuroimage (2006) [Pubmed]
  11. Haloperidol in the treatment of infantile autism: effects on learning and behavioral symptoms. Anderson, L.T., Campbell, M., Grega, D.M., Perry, R., Small, A.M., Green, W.H. The American journal of psychiatry. (1984) [Pubmed]
  12. Simultaneous olfactory discrimination elicits a strain-specific increase in dendritic spines in the hippocampus of inbred mice. Restivo, L., Roman, F.S., Ammassari-Teule, M., Marchetti, E. Hippocampus. (2006) [Pubmed]
  13. Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys. Jentsch, J.D., Olausson, P., De La Garza, R., Taylor, J.R. Neuropsychopharmacology (2002) [Pubmed]
  14. Effect of sex and age on brain monoamines and spatial learning in rats. Tanila, H., Taira, T., Piepponen, T.P., Honkanen, A. Neurobiol. Aging (1994) [Pubmed]
  15. Exposure to chronic psychosocial stress and corticosterone in the rat: effects on spatial discrimination learning and hippocampal protein kinase Cgamma immunoreactivity. Krugers, H.J., Douma, B.R., Andringa, G., Bohus, B., Korf, J., Luiten, P.G. Hippocampus. (1997) [Pubmed]
  16. Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat. Telner, J.I., Vikis-Freibergs, V., Lepore, F. Psychopharmacologia. (1976) [Pubmed]
  17. Perceptual learning modulates sensory evoked response during vowel segregation. Reinke, K.S., He, Y., Wang, C., Alain, C. Brain research. Cognitive brain research. (2003) [Pubmed]
  18. Learning ability in adult female rats perinatally exposed to methadone. Zagon, I.S., McLaughlin, P.J., Thompson, C.I. Pharmacol. Biochem. Behav. (1979) [Pubmed]
  19. Alterations in the immunoreactivity for muscarinic acetylcholine receptors and colocalized PKC gamma in mouse hippocampus induced by spatial discrimination learning. Van der Zee, E.A., Compaan, J.C., Bohus, B., Luiten, P.G. Hippocampus. (1995) [Pubmed]
  20. Learning-induced plasticity of N-methyl-D-aspartate receptors is task and region specific. Roullet, P., Bourne, R., Moricard, Y., Stewart, M.G., Sara, S.J. Neuroscience (1999) [Pubmed]
  21. The relationship between learning performance and dopamine in the prefrontal cortex of the rat. Yamamuro, Y., Hori, K., Iwano, H., Nomura, M. Neurosci. Lett. (1994) [Pubmed]
  22. Prenatal exposure to cocaine disrupts discrimination learning in adult rabbits. Romano, A.G., Harvey, J.A. Pharmacol. Biochem. Behav. (1996) [Pubmed]
  23. Dynamics of learning-induced cellular modifications in the cortex. Barkai, E. Biological cybernetics. (2005) [Pubmed]
  24. Spatial discrimination learning and CA1 hippocampal synaptic plasticity in mdx and mdx3cv mice lacking dystrophin gene products. Vaillend, C., Billard, J.M., Claudepierre, T., Rendon, A., Dutar, P., Ungerer, A. Neuroscience (1998) [Pubmed]
  25. Hippocalcin-deficient mice display a defect in cAMP response element-binding protein activation associated with impaired spatial and associative memory. Kobayashi, M., Masaki, T., Hori, K., Masuo, Y., Miyamoto, M., Tsubokawa, H., Noguchi, H., Nomura, M., Takamatsu, K. Neuroscience (2005) [Pubmed]
  26. Spatial learning and synaptic hippocampal plasticity in type 2 somatostatin receptor knock-out mice. Dutar, P., Vaillend, C., Viollet, C., Billard, J.M., Potier, B., Carlo, A.S., Ungerer, A., Epelbaum, J. Neuroscience (2002) [Pubmed]
  27. Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions. Thompson, R., Gibbs, R.B., Ristic, G.A., Cotman, C.W., Yu, J. Brain Res. (1986) [Pubmed]
  28. Neural cell adhesion molecule (NCAM) null mice do not show a deficit in odour discrimination learning. Schellinck, H.M., Arnold, A., Rafuse, V.F. Behav. Brain Res. (2004) [Pubmed]
  29. Cholinergic learning deficits in the marmoset produced by scopolamine and ICV hemicholinium. Ridley, R.M., Barratt, N.G., Baker, H.F. Psychopharmacology (Berl.) (1984) [Pubmed]
  30. Magnetic field effects on spatial discrimination and melatonin levels in mice. Levine, R.L., Dooley, J.K., Bluni, T.D. Physiol. Behav. (1995) [Pubmed]
  31. Cue valence representation studied by Fos immunocytochemistry after acquisition of a discrimination learning task. Roullet, F., Datiche, F., Liénard, F., Cattarelli, M. Brain Res. Bull. (2004) [Pubmed]
  32. Comparative studies with somatostatin and cysteamine in different behavioral tests on rats. Vécsei, L., Király, C., Bollók, I., Nagy, A., Varga, J., Penke, B., Telegdy, G. Pharmacol. Biochem. Behav. (1984) [Pubmed]
  33. Cyclic estrogen replacement improves cognitive function in aged ovariectomized rhesus monkeys. Rapp, P.R., Morrison, J.H., Roberts, J.A. J. Neurosci. (2003) [Pubmed]
WikiGenes - Universities