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MeSH Review

Frontal Lobe

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Disease relevance of Frontal Lobe


Psychiatry related information on Frontal Lobe


High impact information on Frontal Lobe

  • The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy [11].
  • Clustered attacks of epileptic episodes originating from the frontal lobe during sleep are the main symptoms of autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE, MIM 600513) [11].
  • The Wisconsin Card Sorting Test, which probes the ability to shift attention from one category of stimulus attributes to another (shifting cognitive sets), is the most common paradigm used to detect human frontal lobe pathology [12].
  • In this issue of Neuron, describe the activity of single neurons in the SEF of monkeys, an oculomotor area of the frontal lobe, during the performance of stereotyped sequences of saccades [13].
  • Participants were genotyped for catechol-O-methyltransferase (COMT) at the Val158Met locus, which has been shown to affect executive cognition and frontal lobe function, likely because of genetically determined variation in prefrontal dopamine signaling [14].

Chemical compound and disease context of Frontal Lobe


Biological context of Frontal Lobe


Anatomical context of Frontal Lobe

  • Pathological studies of two brains from affected members of Family MN obtained at autopsy demonstrate numerous tau-positive inclusions that were most prominent in the frontal lobes, anterior temporal lobes, and brainstem structures, as well as Pick-like bodies and associated granulovacuolar degeneration [24].
  • Analysis of individual brain regions revealed significant declines in cerebral glucose utilization in most regions throughout the cerebral cortex, particularly those in the superior half of the frontal lobe [25].
  • In schizophrenics, the alterations in expression of NR2 subunit mRNA in prefrontal cortex are potential indicators of deficits in NMDA receptor-mediated neurotransmission accompanying functional hypoactivity of the frontal lobes [26].
  • In contrast, 8H9 was nonreactive with normal human tissues including bone marrow, colon, stomach, heart, lung, muscle, thyroid, testes, pancreas, and human brain (frontal lobe, cerebellum, pons, and spinal cord) [27].
  • RESULTS: Brain regions that satisfied these criteria were largely left lateralized and included the frontal lobe (medial and middle frontal gyri, bilateral inferior frontal gyrus), parietal lobe (bilateral inferior parietal lobule), insula, and limbic lobe (anterior and posterior cingulate gyrus) [28].

Associations of Frontal Lobe with chemical compounds


Gene context of Frontal Lobe


Analytical, diagnostic and therapeutic context of Frontal Lobe


  1. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Steinlein, O.K., Mulley, J.C., Propping, P., Wallace, R.H., Phillips, H.A., Sutherland, G.R., Scheffer, I.E., Berkovic, S.F. Nat. Genet. (1995) [Pubmed]
  2. Anti-Yo antibodies and cerebellar degeneration in a man with adenocarcinoma of the esophagus. Sutton, I.J., Fursdon Davis, C.J., Esiri, M.M., Hughes, S., Amyes, E.R., Vincent, A. Ann. Neurol. (2001) [Pubmed]
  3. Phosphorus magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Garcia, P.A., Laxer, K.D., van der Grond, J., Hugg, J.W., Matson, G.B., Weiner, M.W. Ann. Neurol. (1994) [Pubmed]
  4. Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions. Owen, A.M., Doyon, J., Dagher, A., Sadikot, A., Evans, A.C. Brain (1998) [Pubmed]
  5. Relationship between frontal lobe lesions and Wisconsin Card Sorting Test performance in patients with multiple sclerosis. Arnett, P.A., Rao, S.M., Bernardin, L., Grafman, J., Yetkin, F.Z., Lobeck, L. Neurology (1994) [Pubmed]
  6. Increased caudate dopamine D2 receptor availability as a genetic marker for schizophrenia. Hirvonen, J., van Erp, T.G., Huttunen, J., Aalto, S., Någren, K., Huttunen, M., Lönnqvist, J., Kaprio, J., Hietala, J., Cannon, T.D. Arch. Gen. Psychiatry (2005) [Pubmed]
  7. Regional brain atrophy in progressive supranuclear palsy and Lewy body disease. Cordato, N.J., Halliday, G.M., Harding, A.J., Hely, M.A., Morris, J.G. Ann. Neurol. (2000) [Pubmed]
  8. Autosomal dominant nocturnal frontal lobe epilepsy. A video-polysomnographic and genetic appraisal of 40 patients and delineation of the epileptic syndrome. Oldani, A., Zucconi, M., Asselta, R., Modugno, M., Bonati, M.T., Dalprà, L., Malcovati, M., Tenchini, M.L., Smirne, S., Ferini-Strambi, L. Brain (1998) [Pubmed]
  9. Abnormal frontal lobe phosphorous metabolism in bipolar disorder. Deicken, R.F., Fein, G., Weiner, M.W. The American journal of psychiatry. (1995) [Pubmed]
  10. Altered serotonin 2A receptor activity in women who have recovered from bulimia nervosa. Kaye, W.H., Frank, G.K., Meltzer, C.C., Price, J.C., McConaha, C.W., Crossan, P.J., Klump, K.L., Rhodes, L. The American journal of psychiatry. (2001) [Pubmed]
  11. The nicotinic receptor beta 2 subunit is mutant in nocturnal frontal lobe epilepsy. De Fusco, M., Becchetti, A., Patrignani, A., Annesi, G., Gambardella, A., Quattrone, A., Ballabio, A., Wanke, E., Casari, G. Nat. Genet. (2000) [Pubmed]
  12. Transient activation of inferior prefrontal cortex during cognitive set shifting. Konishi, S., Nakajima, K., Uchida, I., Kameyama, M., Nakahara, K., Sekihara, K., Miyashita, Y. Nat. Neurosci. (1998) [Pubmed]
  13. Neurons that program what to do and in what order. Schlag, J.D. Neuron (2002) [Pubmed]
  14. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Goldberg, T.E., Egan, M.F., Gscheidle, T., Coppola, R., Weickert, T., Kolachana, B.S., Goldman, D., Weinberger, D.R. Arch. Gen. Psychiatry (2003) [Pubmed]
  15. Autosomal dominant nocturnal frontal-lobe epilepsy: genetic heterogeneity and evidence for a second locus at 15q24. Phillips, H.A., Scheffer, I.E., Crossland, K.M., Bhatia, K.P., Fish, D.R., Marsden, C.D., Howell, S.J., Stephenson, J.B., Tolmie, J., Plazzi, G., Eeg-Olofsson, O., Singh, R., Lopes-Cendes, I., Andermann, E., Andermann, F., Berkovic, S.F., Mulley, J.C. Am. J. Hum. Genet. (1998) [Pubmed]
  16. Positron emission tomography and histopathology in Pick's disease. Kamo, H., McGeer, P.L., Harrop, R., McGeer, E.G., Calne, D.B., Martin, W.R., Pate, B.D. Neurology (1987) [Pubmed]
  17. Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Tamiya, T., Wei, M.X., Chase, M., Ono, Y., Lee, F., Breakefield, X.O., Chiocca, E.A. Gene Ther. (1995) [Pubmed]
  18. Reversibility of hemodynamic hypofrontality in schizophrenia. Geraud, G., Arné-Bès, M.C., Güell, A., Bes, A. J. Cereb. Blood Flow Metab. (1987) [Pubmed]
  19. Frontotemporal dementia and early Alzheimer disease: differentiation with frontal lobe H-1 MR spectroscopy. Ernst, T., Chang, L., Melchor, R., Mehringer, C.M. Radiology. (1997) [Pubmed]
  20. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients. Akbarian, S., Kim, J.J., Potkin, S.G., Hetrick, W.P., Bunney, W.E., Jones, E.G. Arch. Gen. Psychiatry (1996) [Pubmed]
  21. A new locus for autosomal dominant nocturnal frontal lobe epilepsy maps to chromosome 1. Gambardella, A., Annesi, G., De Fusco, M., Patrignani, A., Aguglia, U., Annesi, F., Pasqua, A.A., Spadafora, P., Oliveri, R.L., Valentino, P., Zappia, M., Ballabio, A., Casari, G., Quattrone, A. Neurology (2000) [Pubmed]
  22. Frontal impairment and hypoperfusion in neuroacanthocytosis. Delecluse, F., Deleval, J., Gérard, J.M., Michotte, A., Zegers de Beyl, D. Arch. Neurol. (1991) [Pubmed]
  23. An amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kinetics. Weiland, S., Witzemann, V., Villarroel, A., Propping, P., Steinlein, O. FEBS Lett. (1996) [Pubmed]
  24. From genotype to phenotype: a clinical pathological, and biochemical investigation of frontotemporal dementia and parkinsonism (FTDP-17) caused by the P301L tau mutation. Nasreddine, Z.S., Loginov, M., Clark, L.N., Lamarche, J., Miller, B.L., Lamontagne, A., Zhukareva, V., Lee, V.M., Wilhelmsen, K.C., Geschwind, D.H. Ann. Neurol. (1999) [Pubmed]
  25. Cerebral hypometabolism in progressive supranuclear palsy studied with positron emission tomography. Foster, N.L., Gilman, S., Berent, S., Morin, E.M., Brown, M.B., Koeppe, R.A. Ann. Neurol. (1988) [Pubmed]
  26. Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. Akbarian, S., Sucher, N.J., Bradley, D., Tafazzoli, A., Trinh, D., Hetrick, W.P., Potkin, S.G., Sandman, C.A., Bunney, W.E., Jones, E.G. J. Neurosci. (1996) [Pubmed]
  27. Monoclonal antibody 8H9 targets a novel cell surface antigen expressed by a wide spectrum of human solid tumors. Modak, S., Kramer, K., Gultekin, S.H., Guo, H.F., Cheung, N.K. Cancer Res. (2001) [Pubmed]
  28. Cue-induced cocaine craving: neuroanatomical specificity for drug users and drug stimuli. Garavan, H., Pankiewicz, J., Bloom, A., Cho, J.K., Sperry, L., Ross, T.J., Salmeron, B.J., Risinger, R., Kelley, D., Stein, E.A. The American journal of psychiatry. (2000) [Pubmed]
  29. Brain metabolism in teenagers with attention-deficit hyperactivity disorder. Zametkin, A.J., Liebenauer, L.L., Fitzgerald, G.A., King, A.C., Minkunas, D.V., Herscovitch, P., Yamada, E.M., Cohen, R.M. Arch. Gen. Psychiatry (1993) [Pubmed]
  30. Altered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Akbarian, S., Bunney, W.E., Potkin, S.G., Wigal, S.B., Hagman, J.O., Sandman, C.A., Jones, E.G. Arch. Gen. Psychiatry (1993) [Pubmed]
  31. CHRNB2 is the second acetylcholine receptor subunit associated with autosomal dominant nocturnal frontal lobe epilepsy. Phillips, H.A., Favre, I., Kirkpatrick, M., Zuberi, S.M., Goudie, D., Heron, S.E., Scheffer, I.E., Sutherland, G.R., Berkovic, S.F., Bertrand, D., Mulley, J.C. Am. J. Hum. Genet. (2001) [Pubmed]
  32. Proton magnetic resonance spectroscopic imaging in patients with frontal lobe epilepsy. Garcia, P.A., Laxer, K.D., van der Grond, J., Hugg, J.W., Matson, G.B., Weiner, M.W. Ann. Neurol. (1995) [Pubmed]
  33. The functional anatomy of frontal lobe neglect in the monkey: behavioral and quantitative 2-deoxyglucose studies. Deuel, R.K., Collins, R.C. Ann. Neurol. (1984) [Pubmed]
  34. Catechol-O-methyl transferase Val158Met gene polymorphism in schizophrenia: working memory, frontal lobe MRI morphology and frontal cerebral blood flow. Ho, B.C., Wassink, T.H., O'Leary, D.S., Sheffield, V.C., Andreasen, N.C. Mol. Psychiatry (2005) [Pubmed]
  35. Dose dependent effect of APOE epsilon4 on behavioral symptoms in frontal lobe dementia. Engelborghs, S., Dermaut, B., Mariën, P., Symons, A., Vloeberghs, E., Maertens, K., Somers, N., Goeman, J., Rademakers, R., Van den Broeck, M., Pickut, B., Cruts, M., Van Broeckhoven, C., De Deyn, P.P. Neurobiol. Aging (2006) [Pubmed]
  36. MRI and genetic correlates of cognitive function in elders with memory impairment. Bartrés-Faz, D., Junqué, C., Clemente, I.C., Serra-Grabulosa, J.M., Guardia, J., López-Alomar, A., Sánchez-Aldeguer, J., Mercader, J.M., Bargalló, N., Olondo, M., Moral, P. Neurobiol. Aging (2001) [Pubmed]
  37. Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library. Marazziti, D., Golini, E., Gallo, A., Lombardi, M.S., Matteoni, R., Tocchini-Valentini, G.P. Genomics (1997) [Pubmed]
  38. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD). Turic, D., Williams, H., Langley, K., Owen, M., Thapar, A., O'Donovan, M.C. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005) [Pubmed]
  39. EEG predicts surgical outcome in lesional frontal lobe epilepsy. Janszky, J., Jokeit, H., Schulz, R., Hoppe, M., Ebner, A. Neurology (2000) [Pubmed]
  40. Presenilin-1-associated abnormalities in regional cerebral perfusion. Johnson, K.A., Lopera, F., Jones, K., Becker, A., Sperling, R., Hilson, J., Londono, J., Siegert, I., Arcos, M., Moreno, S., Madrigal, L., Ossa, J., Pineda, N., Ardila, A., Roselli, M., Albert, M.S., Kosik, K.S., Rios, A. Neurology (2001) [Pubmed]
  41. Quantitative assessment of cerebral blood flow in genetically confirmed spinocerebellar ataxia type 6. Honjo, K., Ohshita, T., Kawakami, H., Naka, H., Imon, Y., Maruyama, H., Mimori, Y., Matsumoto, M. Arch. Neurol. (2004) [Pubmed]
  42. Number processing and basal ganglia dysfunction: a single case study. Delazer, M., Domahs, F., Lochy, A., Karner, E., Benke, T., Poewe, W. Neuropsychologia. (2004) [Pubmed]
  43. Lateral frontal lobe seizures. Kotagal, P., Arunkumar, G.S. Epilepsia (1998) [Pubmed]
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