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MeSH Review

Temporal Lobe

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Disease relevance of Temporal Lobe


Psychiatry related information on Temporal Lobe


High impact information on Temporal Lobe


Chemical compound and disease context of Temporal Lobe


Biological context of Temporal Lobe


Anatomical context of Temporal Lobe

  • The EphA4 receptor tyrosine kinase regulates the formation of the corticospinal tract (CST), a pathway controlling voluntary movements, and of the anterior commissure (AC), connecting the neocortical temporal lobes [26].
  • Fluphenazine, but not clozapine, increased metabolic rates in the subcortical and lateral temporal lobes, whereas clozapine, but not fluphenazine, decreased inferior prefrontal cortex activity [27].
  • Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe (amygdala), and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving [28].
  • Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy [29].
  • Similar results were observed in 13 specimens of anterolateral temporal neocortex obtained during temporal lobectomies in patients with intractable temporal lobe epilepsy, compared with postmortem human specimen or control brain tissues [30].

Associations of Temporal Lobe with chemical compounds


Gene context of Temporal Lobe

  • CONCLUSIONS: Specific alleles of the DISC1 and TRAX genes on 1q42 appear to contribute to genetic risk for schizophrenia through disruptive effects on the structure and function of the prefrontal cortex, medial temporal lobe, and other brain regions [35].
  • LGI1, one member of the LGI gene family, encodes a approximately 63 kDa protein, with strong regional expression in neurons within the temporal lobe [36].
  • We also show that changes in the expression of other ITFs (Fos, Jun-D and Krox-20) and the BDNF/trkB neurotrophin system may play a central role in the development of hippocampal kindling, an animal model of human temporal lobe epilepsy [37].
  • These findings indicate that chronic temporal lobe seizures are associated with differential changes in hippocampal NR1 and NR2A-D hybridization densities that vary by subfield and clinical-pathological category [38].
  • Death-associated protein kinase expression in human temporal lobe epilepsy [23].

Analytical, diagnostic and therapeutic context of Temporal Lobe


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  3. Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy. Rice, A., Rafiq, A., Shapiro, S.M., Jakoi, E.R., Coulter, D.A., DeLorenzo, R.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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  7. Behavioral symptoms in temporal lobe epilepsy. Bear, D.M. Arch. Gen. Psychiatry (1983) [Pubmed]
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  12. A randomized, controlled trial of surgery for temporal-lobe epilepsy. Wiebe, S., Blume, W.T., Girvin, J.P., Eliasziw, M. N. Engl. J. Med. (2001) [Pubmed]
  13. Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. Teitelbaum, J.S., Zatorre, R.J., Carpenter, S., Gendron, D., Evans, A.C., Gjedde, A., Cashman, N.R. N. Engl. J. Med. (1990) [Pubmed]
  14. Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine. Saunders, R.C., Kolachana, B.S., Bachevalier, J., Weinberger, D.R. Nature (1998) [Pubmed]
  15. Hippocampal GABA transporter function in temporal-lobe epilepsy. During, M.J., Ryder, K.M., Spencer, D.D. Nature (1995) [Pubmed]
  16. A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year. Bing, G., Wilson, B., Hudson, P., Jin, L., Feng, Z., Zhang, W., Bing, R., Hong, J.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Hippocampal N-acetylaspartate in neocortical epilepsy and mesial temporal lobe epilepsy. Vermathen, P., Ende, G., Laxer, K.D., Knowlton, R.C., Matson, G.B., Weiner, M.W. Ann. Neurol. (1997) [Pubmed]
  18. Synchronous GABA-mediated potentials and epileptiform discharges in the rat limbic system in vitro. Avoli, M., Barbarosie, M., Lücke, A., Nagao, T., Lopantsev, V., Köhling, R. J. Neurosci. (1996) [Pubmed]
  19. LGI1 is mutated in familial temporal lobe epilepsy characterized by aphasic seizures. Gu, W., Brodtkorb, E., Steinlein, O.K. Ann. Neurol. (2002) [Pubmed]
  20. Increased leukotriene C4 and vasogenic edema surrounding brain tumors in humans. Black, K.L., Hoff, J.T., McGillicuddy, J.E., Gebarski, S.S. Ann. Neurol. (1986) [Pubmed]
  21. Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors. Grunwald, T., Beck, H., Lehnertz, K., Blümcke, I., Pezer, N., Kurthen, M., Fernández, G., Van Roost, D., Heinze, H.J., Kutas, M., Elger, C.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. A selective loss of somatostatin in the hippocampus of patients with temporal lobe epilepsy. Robbins, R.J., Brines, M.L., Kim, J.H., Adrian, T., de Lanerolle, N., Welsh, S., Spencer, D.D. Ann. Neurol. (1991) [Pubmed]
  23. Death-associated protein kinase expression in human temporal lobe epilepsy. Henshall, D.C., Schindler, C.K., So, N.K., Lan, J.Q., Meller, R., Simon, R.P. Ann. Neurol. (2004) [Pubmed]
  24. Evidence for digenic inheritance in a family with both febrile convulsions and temporal lobe epilepsy implicating chromosomes 18qter and 1q25-q31. Baulac, S., Picard, F., Herman, A., Feingold, J., Genin, E., Hirsch, E., Prud'homme, J.F., Baulac, M., Brice, A., LeGuern, E. Ann. Neurol. (2001) [Pubmed]
  25. A functional polymorphism in the prodynorphin gene promotor is associated with temporal lobe epilepsy. Stögmann, E., Zimprich, A., Baumgartner, C., Aull-Watschinger, S., Höllt, V., Zimprich, F. Ann. Neurol. (2002) [Pubmed]
  26. Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo. Kullander, K., Mather, N.K., Diella, F., Dottori, M., Boyd, A.W., Klein, R. Neuron (2001) [Pubmed]
  27. The brain metabolic patterns of clozapine- and fluphenazine-treated patients with schizophrenia during a continuous performance task. Cohen, R.M., Nordahl, T.E., Semple, W.E., Andreason, P., Litman, R.E., Pickar, D. Arch. Gen. Psychiatry (1997) [Pubmed]
  28. Activation of memory circuits during cue-elicited cocaine craving. Grant, S., London, E.D., Newlin, D.B., Villemagne, V.L., Liu, X., Contoreggi, C., Phillips, R.L., Kimes, A.S., Margolin, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  29. Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy. Palma, E., Esposito, V., Mileo, A.M., Di Gennaro, G., Quarato, P., Giangaspero, F., Scoppetta, C., Onorati, P., Trettel, F., Miledi, R., Eusebi, F. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. Glial and neuronal Na+-K+ pump in epilepsy. Grisar, T. Ann. Neurol. (1984) [Pubmed]
  31. Chlorazepate in temporal lobe epilepsy. Feldman, R.G. JAMA (1976) [Pubmed]
  32. Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study. Bartzokis, G., Beckson, M., Lu, P.H., Nuechterlein, K.H., Edwards, N., Mintz, J. Arch. Gen. Psychiatry (2001) [Pubmed]
  33. Left planum temporale volume reduction in schizophrenia. Kwon, J.S., McCarley, R.W., Hirayasu, Y., Anderson, J.E., Fischer, I.A., Kikinis, R., Jolesz, F.A., Shenton, M.E. Arch. Gen. Psychiatry (1999) [Pubmed]
  34. Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Akbarian, S., Viñuela, A., Kim, J.J., Potkin, S.G., Bunney, W.E., Jones, E.G. Arch. Gen. Psychiatry (1993) [Pubmed]
  35. Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Cannon, T.D., Hennah, W., van Erp, T.G., Thompson, P.M., Lonnqvist, J., Huttunen, M., Gasperoni, T., Tuulio-Henriksson, A., Pirkola, T., Toga, A.W., Kaprio, J., Mazziotta, J., Peltonen, L. Arch. Gen. Psychiatry (2005) [Pubmed]
  36. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Senechal, K.R., Thaller, C., Noebels, J.L. Hum. Mol. Genet. (2005) [Pubmed]
  37. Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system. Hughes, P.E., Alexi, T., Walton, M., Williams, C.E., Dragunow, M., Clark, R.G., Gluckman, P.D. Prog. Neurobiol. (1999) [Pubmed]
  38. Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Mathern, G.W., Pretorius, J.K., Mendoza, D., Leite, J.P., Chimelli, L., Born, D.E., Fried, I., Assirati, J.A., Ojemann, G.A., Adelson, P.D., Cahan, L.D., Kornblum, H.I. Ann. Neurol. (1999) [Pubmed]
  39. Real-time tracking of memory formation in the human rhinal cortex and hippocampus. Fernández, G., Effern, A., Grunwald, T., Pezer, N., Lehnertz, K., Dümpelmann, M., Van Roost, D., Elger, C.E. Science (1999) [Pubmed]
  40. Epileptic seizures may begin hours in advance of clinical onset: a report of five patients. Litt, B., Esteller, R., Echauz, J., D'Alessandro, M., Shor, R., Henry, T., Pennell, P., Epstein, C., Bakay, R., Dichter, M., Vachtsevanos, G. Neuron (2001) [Pubmed]
  41. Cardiac arrest in rodents: maximal duration compatible with a recovery of neuronal activity. Charpak, S., Audinat, E. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  42. Decreased hippocampal muscarinic cholinergic receptor binding measured by 123I-iododexetimide and single-photon emission computed tomography in epilepsy. Müller-Gärtner, H.W., Mayberg, H.S., Fisher, R.S., Lesser, R.P., Wilson, A.A., Ravert, H.T., Dannals, R.F., Wagner, H.N., Uematsu, S., Frost, J.J. Ann. Neurol. (1993) [Pubmed]
  43. Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy. Parent, J.M., Elliott, R.C., Pleasure, S.J., Barbaro, N.M., Lowenstein, D.H. Ann. Neurol. (2006) [Pubmed]
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