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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Renal CO2 production from glutamine and lactate as a function of arterial perfusion pressure in dog.

The energy cost of renal function in the intact kidney of the dog was assessed at a series of arterial perfusion pressures. Pressure was varied by partially inflating a balloon at the tip of a catheter positioned in the aorta above the origins of the renal arteries.Either L-[U-14C]-lactate was infused intravenously in tracer amounts throughout each experiment. Total renal CO2 production and 14CO2 production from each isotope permitted assessment of total renal oxidative metabolism and the proportions derived from the two major substrates of the kidney. Stepwise inflation of the aortic balloon progressively lowered glomerular filtration rate, renal blood inflow, filtered and consequently reabsorbed Na+, total renal CO2 production, and 14CO2 derived from glutamine and lactate. The percent of total CO2 derived from lactate decreased more or less in proportion to the decrease in percent of total CO2 produced. Results were consistent with the view that reabsorption of sodium is the major energy sink of the kidney. They suggest that the oxidation of glutamine supplies energy for tubular transport and basal demands such as synthesis of hormones and maintenance of structure, whereas the oxidation of lactate supplies energy mainly for transport activities.[1]


  1. Renal CO2 production from glutamine and lactate as a function of arterial perfusion pressure in dog. Baruch, S.B., Eun, C.K., MacLeod, M., Pitts, R.F. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
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