Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Meirelles-Santos, J.O. et al.

Absolute ethanol and 5% ethanolamine oleate are comparable for sclerotherapy of esophageal varices.

BACKGROUND: Endoscopic sclerotherapy is widely accepted as an effective treatment for the eradication of esophageal varices in patients with portal hypertension and a history of upper gastrointestinal bleeding. The objective of this study was to assess the effectiveness and safety of absolute ethanol as an alternative sclerosing agent to the commonly used 5% ethanolamine oleate. METHODS: One hundred fifty-seven patients with portal hypertension and a history of variceal bleeding were randomly assigned to sclerotherapy with absolute ethanol (n = 66) or 5% ethanolamine oleate (n = 91) between January 1992 and July 1994. Once eradication was achieved, these patients were prospectively followed until September 1998. RESULTS: Sclerotherapy with both sclerosants resulted in similar eradication rates (approximately 90%), with comparable numbers of sessions required for eradication (5.4 and 5.9 sessions for absolute ethanol and 5% ethanolamine oleate, respectively). Similar complication and recurrent bleeding rates were observed among both groups. CONCLUSION: Sclerotherapy with absolute ethanol is as effective as with 5% ethanolamine oleate in preventing further bleeding in patients with portal hypertension.[1]

References

Absolute ethanol and 5% ethanolamine oleate are comparable for sclerotherapy of esophageal varices. Meirelles-Santos, J.O., Carvalho, A.F., Callejas-Neto, F., Magna, L.A., Yamanaka, A., Zeitune, J.M., Brandalise, N.A., Ferraz, J.G. Gastrointest. Endosc. (2000) [Pubmed]

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