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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain.

Using the northern blot technique, the steady-state levels for the mRNAs encoding acyl-CoA oxidase, pristanoyl-CoA oxidase, trans2, 3enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase multifunctional enzyme type 2, 3-ketoacyl-CoA thiolase and sterol-carrier-protein x during postnatal brain development were measured. The developmental patterns obtained for each mRNA species studied were similar, with an increase in the mRNA level between birth and postnatal day 5, followed by a gradual decrease to 34-55% of the maximal value at postnatal day 30. These results are in agreement with a coordinately controlled expression of the genes involved in VLCFA beta-oxidation during brain development. Moreover, comparison of these developmental profiles with that obtained for ceramide galactosyltransferase showed that the set-up of the very-long-chain fatty acids beta-oxidation system is independent of the myelinating signal in the central nervous system.[1]


  1. Peroxisomal beta-oxidation enzyme gene expression in the developing mouse brain. Knoll, A., Salles, J., Sargueil, F., Cassagne, C., Garbay, B. Neurosci. Lett. (2000) [Pubmed]
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