Gene Review:
Acox1 - acyl-Coenzyme A oxidase 1, palmitoyl
Mus musculus
Synonyms:
AI042784, AOX, Acox, Acyl-CoA oxidase, D130055E20Rik, ...
- Peroxisomal and mitochondrial fatty acid beta-oxidation in mice nullizygous for both peroxisome proliferator-activated receptor alpha and peroxisomal fatty acyl-CoA oxidase. Genotype correlation with fatty liver phenotype. Hashimoto, T., Fujita, T., Usuda, N., Cook, W., Qi, C., Peters, J.M., Gonzalez, F.J., Yeldandi, A.V., Rao, M.S., Reddy, J.K. J. Biol. Chem. (1999)
- Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. Fan, C.Y., Pan, J., Usuda, N., Yeldandi, A.V., Rao, M.S., Reddy, J.K. J. Biol. Chem. (1998)
- Molecular profiling of hepatocellular carcinomas developing spontaneously in acyl-CoA oxidase deficient mice: comparison with liver tumors induced in wild-type mice by a peroxisome proliferator and a genotoxic carcinogen. Meyer, K., Lee, J.S., Dyck, P.A., Cao, W.Q., Rao, M.S., Thorgeirsson, S.S., Reddy, J.K. Carcinogenesis (2003)
- Down-regulation of acyl-CoA oxidase gene expression and increased NF-kappaB activity in etomoxir-induced cardiac hypertrophy. Cabrero, A., Merlos, M., Laguna, J.C., Carrera, M.V. J. Lipid Res. (2003)
- Dose-response relationships of hepatic acyl-CoA oxidase and catalase activity and liver mitogenesis induced by the peroxisome proliferator ciprofibrate in C57BL/6N and BALB/c mice. Budroe, J.D., Umemura, T., Angeloff, K., Williams, G.M. Toxicol. Appl. Pharmacol. (1992)
- Cardiac peroxisomal enzymes and starvation. Crescimanno, M., Armata, M.G., Rausa, L., Gueli, M.C., Nicotra, C., D'Alessandro, N. Free Radic. Res. Commun. (1989)
- Application of comparative functional genomics to identify best-fit mouse models to study human cancer. Lee, J.S., Chu, I.S., Mikaelyan, A., Calvisi, D.F., Heo, J., Reddy, J.K., Thorgeirsson, S.S. Nat. Genet. (2004)
- Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. Berthou, L., Duverger, N., Emmanuel, F., Langouët, S., Auwerx, J., Guillouzo, A., Fruchart, J.C., Rubin, E., Denèfle, P., Staels, B., Branellec, D. J. Clin. Invest. (1996)
- FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes. Wouters, F.S., Bastiaens, P.I., Wirtz, K.W., Jovin, T.M. EMBO J. (1998)
- The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene. Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L., Green, S. EMBO J. (1992)
- Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression. Marcus, S.L., Miyata, K.S., Zhang, B., Subramani, S., Rachubinski, R.A., Capone, J.P. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Phytanic acid activates the peroxisome proliferator-activated receptor alpha (PPARalpha) in sterol carrier protein 2-/ sterol carrier protein x-deficient mice. Ellinghaus, P., Wolfrum, C., Assmann, G., Spener, F., Seedorf, U. J. Biol. Chem. (1999)
- Induction of hepatic peroxisome proliferation in mice by lactofen, a diphenyl ether herbicide. Butler, E.G., Tanaka, T., Ichida, T., Maruyama, H., Leber, A.P., Williams, G.M. Toxicol. Appl. Pharmacol. (1988)
- Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? Cattley, R.C., DeLuca, J., Elcombe, C., Fenner-Crisp, P., Lake, B.G., Marsman, D.S., Pastoor, T.A., Popp, J.A., Robinson, D.E., Schwetz, B., Tugwood, J., Wahli, W. Regulatory toxicology and pharmacology : RTP. (1998)
- Heneicosapentaenoate (21:5n-3): its incorporation into lipids and its effects on arachidonic acid and eicosanoid synthesis. Larsen, L.N., Høvik, K., Bremer, J., Holm, K.H., Myhren, F., Børretzen, B. Lipids (1997)
- Examination of potential mechanisms of carcinogenicity of 1,4-dioxane in rat nasal epithelial cells and hepatocytes. Goldsworthy, T.L., Monticello, T.M., Morgan, K.T., Bermudez, E., Wilson, D.M., Jäckh, R., Butterworth, B.E. Arch. Toxicol. (1991)
- Peroxisome proliferator-activated receptor alpha-responsive genes induced in the newborn but not prenatal liver of peroxisomal fatty acyl-CoA oxidase null mice. Cook, W.S., Jain, S., Jia, Y., Cao, W.Q., Yeldandi, A.V., Reddy, J.K., Rao, M.S. Exp. Cell Res. (2001)
- Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. Ip, E., Farrell, G.C., Robertson, G., Hall, P., Kirsch, R., Leclercq, I. Hepatology (2003)
- Identification of novel peroxisome proliferator-activated receptor alpha (PPARalpha) target genes in mouse liver using cDNA microarray analysis. Cherkaoui-Malki, M., Meyer, K., Cao, W.Q., Latruffe, N., Yeldandi, A.V., Rao, M.S., Bradfield, C.A., Reddy, J.K. Gene Expr. (2001)
- cDNA cloning and analysis of tissue-specific expression of mouse peroxisomal straight-chain acyl-CoA oxidase. Nöhammer, C., El-Shabrawi, Y., Schauer, S., Hiden, M., Berger, J., Forss-Petter, S., Winter, E., Eferl, R., Zechner, R., Hoefler, G. Eur. J. Biochem. (2000)
- Protein organization in mouse liver peroxisomes. Poole, C.B., Crane, D.I. Arch. Biochem. Biophys. (1992)
- Detection of peroxisomal proteins and their mRNAs in serial sections of fetal and newborn mouse organs. Grabenbauer, M., Fahimi, H.D., Baumgart, E. J. Histochem. Cytochem. (2001)
- Expression of peroxisome proliferator-activated receptor alpha, and PPARalpha regulated genes in spontaneously developed hepatocellular carcinomas in fatty acyl-CoA oxidase null mice. Meyer, K., Jia, Y., Cao, W.Q., Kashireddy, P., Rao, M.S. Int. J. Oncol. (2002)
- In vitro steady-state levels of hydrogen peroxide after exposure of male F344 rats and female B6C3F1 mice to hepatic peroxisome proliferators. Tomaszewski, K.E., Agarwal, D.K., Melnick, R.L. Carcinogenesis (1986)
- Pretranslational upregulation of microsomal CYP4A in rat liver by intake of a high-sucrose, lipid-devoid diet containing orotic acid. Su, G.M., Fiala-Beer, E., Weber, J., Jahn, D., Robertson, G.R., Murray, M. Biochem. Pharmacol. (2005)
- Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-alpha dependent. Barclay, T.B., Peters, J.M., Sewer, M.B., Ferrari, L., Gonzalez, F.J., Morgan, E.T. J. Pharmacol. Exp. Ther. (1999)
- The peroxisome proliferator-activated receptor mediates the induction of CYP4A6, a cytochrome P450 fatty acid omega-hydroxylase, by clofibric acid. Muerhoff, A.S., Griffin, K.J., Johnson, E.F. J. Biol. Chem. (1992)
- Expression of the hydrogen peroxide-generating enzyme fatty acyl CoA oxidase activates NF-kappaB. Li, Y., Tharappel, J.C., Cooper, S., Glenn, M., Glauert, H.P., Spear, B.T. DNA Cell Biol. (2000)
- Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. Hashimoto, T., Cook, W.S., Qi, C., Yeldandi, A.V., Reddy, J.K., Rao, M.S. J. Biol. Chem. (2000)
- Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. Qi, C., Zhu, Y., Pan, J., Usuda, N., Maeda, N., Yeldandi, A.V., Rao, M.S., Hashimoto, T., Reddy, J.K. J. Biol. Chem. (1999)
- Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Yeldandi, A.V., Rao, M.S., Reddy, J.K. Mutat. Res. (2000)
- cDNA cloning and mRNA distribution of a mouse very long-chain acyl-CoA synthetase. Berger, J., Truppe, C., Neumann, H., Forss-Petter, S. FEBS Lett. (1998)
- Fenofibrate, a ligand for PPARalpha, inhibits aromatase cytochrome P450 expression in the ovary of mouse. Toda, K., Okada, T., Miyaura, C., Saibara, T. J. Lipid Res. (2003)