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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations.

AML1 is a transcriptional activator that is essential for normal hematopoietic development. It is the most frequent target for translocations in acute leukemia. We recently identified 3 patients in whom pancytopenia developed almost 50 years after high-level radiation exposure from nuclear explosions during or after World War II. In all 3 patients, acute myeloid leukemia (AML) eventually developed that had similar characteristics and clinical courses. Cytogenetics from the 3 patients revealed a t(1;21)(p36;q22), a t(18;21)(q21;q22), and a t(19;21)(q13.4;q22). By fluorescent in situ hybridization (FISH), all 3 translocations disrupted the AML1 gene. Two of these AML1 translocations, the t(18;21) and the t(19;21), have not been reported previously. It is possible that the AML1 gene is a target for radiation-induced AML. (Blood. 2000;95:4011-4013)[1]


  1. A novel syndrome of radiation-associated acute myeloid leukemia involving AML1 gene translocations. Hromas, R., Shopnick, R., Jumean, H.G., Bowers, C., Varella-Garcia, M., Richkind, K. Blood (2000) [Pubmed]
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