The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pancytopenia


Psychiatry related information on Pancytopenia


High impact information on Pancytopenia


Chemical compound and disease context of Pancytopenia


Biological context of Pancytopenia


Anatomical context of Pancytopenia


Gene context of Pancytopenia

  • Apart from demonstrating again that MRA cells and CFU-S-13 are separate functional entities, the data thus showed that TPO promotes short-term multilineage repopulating cells at the expense of more immature ancestral cells, thereby preventing pancytopenia [26].
  • We previously reported that mice lacking wild-type HIF-2alpha, encoded by the EPAS1 gene, exhibit pancytopenia [27].
  • Interestingly, approximately 30% of primary recipients (7 of 22) transplanted with uncorrected Fancc(-/-) cells developed a range of hematopoietic abnormalities including pancytopenia and BM hypoplasia similar to individuals with FA [28].
  • Fanconi anemia (FA), an autosomal recessive disorder characterized by a progressive pancytopenia associated with congenital anomalies and high predisposition to malignancies, is a genetically and clinically heterogeneous disease [29].
  • Virus-infected control mice not receiving IL-3/GM-CSF developed pancytopenia [30].

Analytical, diagnostic and therapeutic context of Pancytopenia


  1. Mutations of the Fanconi anemia group A gene (FAA) in Italian patients. Savino, M., Ianzano, L., Strippoli, P., Ramenghi, U., Arslanian, A., Bagnara, G.P., Joenje, H., Zelante, L., Savoia, A. Am. J. Hum. Genet. (1997) [Pubmed]
  2. International Fanconi Anemia Registry: relation of clinical symptoms to diepoxybutane sensitivity. Auerbach, A.D., Rogatko, A., Schroeder-Kurth, T.M. Blood (1989) [Pubmed]
  3. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Jordan, M.B., Hildeman, D., Kappler, J., Marrack, P. Blood (2004) [Pubmed]
  4. Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism. Koury, M.J., Price, J.O., Hicks, G.G. Blood (2000) [Pubmed]
  5. Reversible pancytopenia caused by oral letrozole assumption in a patient with recurrent breast cancer. Sperone, P., Gorzegno, G., Berruti, A., Familiari, U., Dogliotti, L. J. Clin. Oncol. (2002) [Pubmed]
  6. The longest surviving child with Hoyeraal-Hreidarsson Syndrome. Ozdemir, M.A., Karakukcu, M., Kose, M., Kumandas, S., Gumus, H. Haematologica (2004) [Pubmed]
  7. Azathioprine for long-term maintenance of remission in autoimmune hepatitis. Johnson, P.J., McFarlane, I.G., Williams, R. N. Engl. J. Med. (1995) [Pubmed]
  8. Pancytopenia following low-dose methotrexate therapy. Abel, E.A., Farber, E.M. JAMA (1988) [Pubmed]
  9. Pancytopenia induced by cephalothin. Tartas, N.E., Bullorsky, E.O., Hevia, J.E., Avalos, J.C. JAMA (1981) [Pubmed]
  10. Severe transient pancytopenia associated with procainamide ingestion. Bluming, A.Z., Plotkin, D., Rosen, P., Thiessen, A.R. JAMA (1976) [Pubmed]
  11. Acute folate deficiency in surgical patients on aminoacid/ethanol intravenous nutrition. Wardrop, C.A., Heatley, R.V., Tennant, G.B., Hughes, L.E. Lancet (1975) [Pubmed]
  12. Pancytopenia with cimetidine. De Galocsy, C., Van Ypersele de Strihou, C. Ann. Intern. Med. (1979) [Pubmed]
  13. Pancytopenia and methotrexate with trimethoprim-sulfamethoxazole. Jeurissen, M.E., Boerbooms, A.M., van de Putte, L.B. Ann. Intern. Med. (1989) [Pubmed]
  14. Fatal pancytopenia associated with the use of captopril. Gavras, I., Graff, L.G., Rose, B.D., McKenna, J.M., Brunner, H.R., Gavras, H. Ann. Intern. Med. (1981) [Pubmed]
  15. Cimetidine, cloxacillin, and pancytopenia. Westerman, E.L. Ann. Intern. Med. (1979) [Pubmed]
  16. Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus. Binder, D., Fehr, J., Hengartner, H., Zinkernagel, R.M. J. Exp. Med. (1997) [Pubmed]
  17. Pancytopenia as a clonal disorder of a multipotent hematopoietic stem cell. Abkowitz, J.L., Fialkow, P.J., Niebrugge, D.J., Raskind, W.H., Adamson, J.W. J. Clin. Invest. (1984) [Pubmed]
  18. Characterization of the 5' region of the Fanconi anaemia group C (FACC) gene. Savoia, A., Centra, M., Ianzano, L., de Cillis, G.P., Zelante, L., Buchwald, M. Hum. Mol. Genet. (1995) [Pubmed]
  19. The emergence of Ph-, trisomy -8+ cells in patients with chronic myeloid leukemia treated with imatinib mesylate. Feldman, E., Najfeld, V., Schuster, M., Roboz, G., Chadburn, A., Silver, R.T. Exp. Hematol. (2003) [Pubmed]
  20. Immune basis for cimetidine-induced pancytopenia. Nagler, A., Rozenbaum, H., Enat, R., Tatarsky, I., Katz, R., Pollack, S. Am. J. Gastroenterol. (1987) [Pubmed]
  21. Pancytopenia and hepatosplenomegaly in oxalosis. Hricik, D.E., Hussain, R. Arch. Intern. Med. (1984) [Pubmed]
  22. Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases. Bacon, B.R., Treuhaft, W.H., Goodman, A.M. Arch. Intern. Med. (1981) [Pubmed]
  23. Insulin-resistant diabetes with insulin receptor autoantibodies in a male patient without acanghosis nigricans. Baldwin, D., Winston, E., Hoshizaki, R.J., Garland, J.T., Baldwin, D., Holcomb, H.H., Flier, J.S., Rubenstein, A. Diabetes Care (1979) [Pubmed]
  24. Serum monocyte colony-stimulating factor, erythropoietin and interleukin-6 in relation to pancytopenia in hairy cell leukemia. Jansen, J.H., Wientjens, G.J., Fibbe, W.E., Ralph, P., Van Damme, J., den Ottolander, G.J., Willemze, R., Kluin-Nelemans, J.C. Leukemia (1992) [Pubmed]
  25. Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells. Neelis, K.J., Dubbelman, Y.D., Qingliang, L., Thomas, G.R., Eaton, D.L., Wagemaker, G. Exp. Hematol. (1997) [Pubmed]
  26. A single dose of thrombopoietin shortly after myelosuppressive total body irradiation prevents pancytopenia in mice by promoting short-term multilineage spleen-repopulating cells at the transient expense of bone marrow-repopulating cells. Neelis, K.J., Visser, T.P., Dimjati, W., Thomas, G.R., Fielder, P.J., Bloedow, D., Eaton, D.L., Wagemaker, G. Blood (1998) [Pubmed]
  27. HIF-2alpha regulates murine hematopoietic development in an erythropoietin-dependent manner. Scortegagna, M., Ding, K., Zhang, Q., Oktay, Y., Bennett, M.J., Bennett, M., Shelton, J.M., Richardson, J.A., Moe, O., Garcia, J.A. Blood (2005) [Pubmed]
  28. Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution. Haneline, L.S., Li, X., Ciccone, S.L., Hong, P., Yang, Y., Broxmeyer, H.E., Lee, S.H., Orazi, A., Srour, E.F., Clapp, D.W. Blood (2003) [Pubmed]
  29. The FANCA gene in Japanese Fanconi anemia: reports of eight novel mutations and analysis of sequence variability. Tachibana, A., Kato, T., Ejima, Y., Yamada, T., Shimizu, T., Yang, L., Tsunematsu, Y., Sasaki, M.S. Hum. Mutat. (1999) [Pubmed]
  30. Effect of combination interleukin-3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) on hematopoiesis administered to retrovirus-infected immunodeficient mice receiving dose-escalation zidovudine (AZT). Gallicchio, V.S., Hughes, N.K., Tse, K.F., Ling, J., Gaines, H., Bowen, T.E., Uluitu, M. Int. J. Immunopharmacol. (1995) [Pubmed]
  31. Treatment of busulfan-induced pancytopenia. Stuart, J.J., Crocker, D.L., Roberts, H.R. Arch. Intern. Med. (1976) [Pubmed]
  32. Development of a murine model of cerebral aspergillosis. Chiller, T.M., Luque, J.C., Sobel, R.A., Farrokhshad, K., Clemons, K.V., Stevens, D.A. J. Infect. Dis. (2002) [Pubmed]
  33. Lack of efficacy of thrombopoietin and granulocyte-macrophage colony-stimulating factor after total body irradiation and autologous bone marrow transplantation in Rhesus monkeys. Hartong, S.C., Neelis, K.J., Visser, T.P., Wagemaker, G. Exp. Hematol. (2000) [Pubmed]
  34. Acute transverse myelitis and autoimmune pancytopenia after unrelated hematopoietic cell transplantation. Pérez-Montes, R., Richard, C., Baro, J., Pascual, J., Varela, R., Zubizarreta, A. Haematologica (2001) [Pubmed]
WikiGenes - Universities