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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhalation.

In a single-center, randomized study, zanamivir (Relenza) concentrations in induced sputum samples and nasal washings of healthy adults following oral inhalation were measured. Concentrations in sputum exceeded the median viral neuraminidase 50% inhibitory concentration at 6, 12, and 24 h, and those in nasal washings did so at 6 and 12 h. There were no zanamivir-related adverse events or laboratory abnormalities.[1]

References

  1. Direct measurement of the anti-influenza agent zanamivir in the respiratory tract following inhalation. Peng, A.W., Milleri, S., Stein, D.S. Antimicrob. Agents Chemother. (2000) [Pubmed]
 
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