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Chemical Compound Review

Relenza     (4S,5R,6R)-5-acetamido-4...

Synonyms: Zanamavir, Zanamir, zanamivir, GANA, SureCN9501, ...
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Disease relevance of Zanamavir


High impact information on Zanamavir


Anatomical context of Zanamavir


Associations of Zanamavir with other chemical compounds

  • We reported previously that 4-guanidino-neu5Ac2en (4-GU-DANA) and related sialic acid-based inhibitors of HPF3 neuraminidase activity also inhibit HN-mediated receptor binding and fusion processes not involving neuraminidase activity [3].

Analytical, diagnostic and therapeutic context of Zanamavir


  1. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza. Hayden, F.G., Treanor, J.J., Betts, R.F., Lobo, M., Esinhart, J.D., Hussey, E.K. JAMA (1996) [Pubmed]
  2. Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en. Gubareva, L.V., Bethell, R., Hart, G.J., Murti, K.G., Penn, C.R., Webster, R.G. J. Virol. (1996) [Pubmed]
  3. Human parainfluenza virus type 3 HN-receptor interaction: effect of 4-guanidino-Neu5Ac2en on a neuraminidase-deficient variant. Porotto, M., Greengard, O., Poltoratskaia, N., Horga, M.A., Moscona, A. J. Virol. (2001) [Pubmed]
  4. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro. Woods, J.M., Bethell, R.C., Coates, J.A., Healy, N., Hiscox, S.A., Pearson, B.A., Ryan, D.M., Ticehurst, J., Tilling, J., Walcott, S.M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  5. Effects of the neuraminidase inhibitor zanamavir on otologic manifestations of experimental human influenza. Walker, J.B., Hussey, E.K., Treanor, J.J., Montalvo, A., Hayden, F.G. J. Infect. Dis. (1997) [Pubmed]
  6. Inhibition of parainfluenza virus type 3 and Newcastle disease virus hemagglutinin-neuraminidase receptor binding: effect of receptor avidity and steric hindrance at the inhibitor binding sites. Porotto, M., Murrell, M., Greengard, O., Lawrence, M.C., McKimm-Breschkin, J.L., Moscona, A. J. Virol. (2004) [Pubmed]
  7. Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en. Gubareva, L.V., Robinson, M.J., Bethell, R.C., Webster, R.G. J. Virol. (1997) [Pubmed]
  8. Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en. Staschke, K.A., Colacino, J.M., Baxter, A.J., Air, G.M., Bansal, A., Hornback, W.J., Munroe, J.E., Laver, W.G. Virology (1995) [Pubmed]
  9. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Blick, T.J., Tiong, T., Sahasrabudhe, A., Varghese, J.N., Colman, P.M., Hart, G.J., Bethell, R.C., McKimm-Breschkin, J.L. Virology (1995) [Pubmed]
  10. Plasmodium falciparum lacks sialidase and trans-sialidase activity. Clough, B., Atilola, F.A., Healy, N., Pereira, M.E., Bethell, R.C., Penn, C.R., Pasvol, G. Parasitology (1996) [Pubmed]
  11. Anti-influenza virus activity of the neuraminidase inhibitor 4-guanidino-Neu5Ac2en in cell culture and in human respiratory epithelium. Hayden, F.G., Rollins, B.S., Madren, L.K. Antiviral Res. (1994) [Pubmed]
  12. Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture. Colacino, J.M., Laver, W.G., Air, G.M. J. Infect. Dis. (1997) [Pubmed]
  13. Inhibition of replication of avian influenza viruses by the neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid. Gubareva, L.V., Penn, C.R., Webster, R.G. Virology (1995) [Pubmed]
  14. Determination of the novel sialic acid analog GG167 (GR121167X) in human urine by liquid chromatography: direct injection with column switching. Morris, D.M., Hussey, B.K., Geurin, S.L., Selinger, K.A. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
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