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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Recovery of visual field constriction following discontinuation of vigabatrin.

Epilepsy patients treated with vigabatrin may develop symptomatic or asymptomatic concentric visual field constriction due to GABA-associated retinal dysfunction. The prevalence and course of this side effect are not established yet; in previously reported adult patients the visual disturbances seem to be irreversible. We present two patients with a significant improvement of visual field constriction and retinal function after the discontinuation of vigabatrin. These findings suggest that vigabatrin-associated retinal changes are at least partly reversible in some patients, and that these patients may benefit significantly from a withdrawal of vigabatrin. Larger scale clinical studies are needed to identify predictive factors both for the occurrence and reversibility of vigabatrin-associated visual field defects.[1]


  1. Recovery of visual field constriction following discontinuation of vigabatrin. Krakow, K., Polizzi, G., Riordan-Eva, P., Holder, G., MacLeod, W.N., Fish, D.R. Seizure : the journal of the British Epilepsy Association. (2000) [Pubmed]
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