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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid.

We have identified a cDNA, designated HOFNH30, which encodes a 354 amino acid G-protein-coupled receptor (GPCR). This receptor has 96% amino acid identity to the Jurkat-T cell-derived EDG7 and could be a splice variant. RT-PCR analysis demonstrated that HOFNH30 mRNA is expressed in placenta whereas EDG7 mRNA shows highest expression in prostate. The HOFNH30 gene is localized to human chromosome 1p22. 3-1p31. 1. When HOFNH30 was expressed in RBL-2H3 cells, LPA and phosphatidic acid (PA) induced a calcium mobilization response with EC(50) values of 13 nM and 3 microM, respectively. LPA also induced phosphorylation of mitogen-activated protein kinase (p42(MAPK) and p44(MAPK)) in HOFNH30-transfected but not vector-transfected RBL-2H3 cells. In the present study, we have identified a novel variant from the EDG receptor family, a GPCR for which LPA is a high-affinity endogenous ligand.[1]


  1. Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid. Fitzgerald, L.R., Dytko, G.M., Sarau, H.M., Mannan, I.J., Ellis, C., Lane, P.A., Tan, K.B., Murdock, P.R., Wilson, S., Bergsma, D.J., Ames, R.S., Foley, J.J., Campbell, D.A., McMillan, L., Evans, N., Elshourbagy, N.A., Minehart, H., Tsui, P. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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