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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Glucagon: role in the hyperglycemia of diabetes mellitus.

Glucagon suppression by somatostatin reduces or abolishes hyperglycemia in dogs made insulin-deficient by somatostatin, alloxan, or total pancreatectomy. This suggests that the development of severe diabetic hyperglycemia requires the presence of glucagon, whether secreted by pancreatic or newly identified gastrointestinal A cells, as well as a lack of insulin. Glucagon suppression could improve therapeutic glucoregulation in diabetes.[1]


  1. Glucagon: role in the hyperglycemia of diabetes mellitus. Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., Unger, R. Science (1975) [Pubmed]
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