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Disease relevance of Pancreatectomy


High impact information on Pancreatectomy


Chemical compound and disease context of Pancreatectomy


Biological context of Pancreatectomy

  • Since an appreciable fraction of postprandial glucose disposal takes place in the absence of insulin (insulin-independent glucose disposal--IIGD), we have investigated potential changes in this aspect of carbohydrate metabolism before and after bladder-drained pancreatic auto-transplantation (PAT/B) as well as partial pancreatectomy (PPx) [15].
  • Together, these results suggest that in the adult hyperglycaemic GK/Par rat facing pancreatectomy, duct-cell proliferation and apoptosis from the common pancreatic duct, main ducts and small ducts were not impaired compared to the Wistar rat [16].
  • Expression of the c-myc and H-ras oncogenes, and of several genes specifically expressed in adult rat pancreas was investigated by monitoring changes in corresponding mRNA concentrations, by dot-blot hybridization, during the early phase of regeneration following subtotal pancreatectomy [17].
  • The objective of this study was to investigate the role of hypothalamic 5-HT, 5-HT1A and 5-HT2C receptor binding and gene expression in rat model of pancreatic regeneration using 60% pancreatectomy [18].
  • The effects of fetal pancreatectomy on the uptake of oxygen, glucose and lactate by the fetus, uterus and uteroplacental tissues were investigated in chronically catheterized sheep during the last third of gestation [19].

Anatomical context of Pancreatectomy


Associations of Pancreatectomy with chemical compounds


Gene context of Pancreatectomy

  • Immunohistochemical staining of tumor tissue removed at pancreatectomy was positive for ACTH and beta endorphin, and negative for corticotropin-releasing factor (CRF) [29].
  • In this study, cell morphology, proliferative response to serum, alpha-SMactin levels, eNOS expression and activity, cGMP intracellular content, and superoxide anion release were measured in cultures of vSMC obtained from aorta medial layer of ten diabetic (90% pancreatectomy, DR) and ten control (sham surgery, CR) rats [30].
  • After partial pancreatectomy, there was a transient increase of the number of anti-nestin-labeled endothelial cells, but again, no endocrine cells bore beta-galactosidase [31].
  • Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin [32].
  • The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regeneration using 60-70% pancreatectomy [33].

Analytical, diagnostic and therapeutic context of Pancreatectomy


  1. Clinical features of 52 neonates with hyperinsulinism. de Lonlay-Debeney, P., Poggi-Travert, F., Fournet, J.C., Sempoux, C., Vici, C.D., Brunelle, F., Touati, G., Rahier, J., Junien, C., Nihoul-Fékété, C., Robert, J.J., Saudubray, J.M. N. Engl. J. Med. (1999) [Pubmed]
  2. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. Permert, J., Larsson, J., Westermark, G.T., Herrington, M.K., Christmanson, L., Pour, P.M., Westermark, P., Adrian, T.E. N. Engl. J. Med. (1994) [Pubmed]
  3. Prevention of diabetes for up to 13 years by autoislet transplantation after pancreatectomy for chronic pancreatitis. Robertson, R.P., Lanz, K.J., Sutherland, D.E., Kendall, D.M. Diabetes (2001) [Pubmed]
  4. The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas. Allen-Jennings, A.E., Hartman, M.G., Kociba, G.J., Hai, T. J. Biol. Chem. (2001) [Pubmed]
  5. Glucagon, pancreatectomy and ketoacidosis. Unger, R.H. N. Engl. J. Med. (1977) [Pubmed]
  6. Somatic deletion of the imprinted 11p15 region in sporadic persistent hyperinsulinemic hypoglycemia of infancy is specific of focal adenomatous hyperplasia and endorses partial pancreatectomy. de Lonlay, P., Fournet, J.C., Rahier, J., Gross-Morand, M.S., Poggi-Travert, F., Foussier, V., Bonnefont, J.P., Brusset, M.C., Brunelle, F., Robert, J.J., Nihoul-Fékété, C., Saudubray, J.M., Junien, C. J. Clin. Invest. (1997) [Pubmed]
  7. Modulation of proinsulin messenger RNA after partial pancreatectomy in rats. Relationships to glucose homeostasis. Orland, M.J., Chyn, R., Permutt, M.A. J. Clin. Invest. (1985) [Pubmed]
  8. Contribution of the pancreas to circulating somatostatin-like immunoreactivity in the normal dog. Taborsky, G.J., Ensinck, J.W. J. Clin. Invest. (1984) [Pubmed]
  9. Aging is associated with decreased pancreatic acinar cell regeneration and phosphatidylinositol 3-kinase/Akt activation. Watanabe, H., Saito, H., Rychahou, P.G., Uchida, T., Evers, B.M. Gastroenterology (2005) [Pubmed]
  10. Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation. Cuesta-Muñoz, A.L., Huopio, H., Otonkoski, T., Gomez-Zumaquero, J.M., Näntö-Salonen, K., Rahier, J., López-Enriquez, S., García-Gimeno, M.A., Sanz, P., Soriguer, F.C., Laakso, M. Diabetes (2004) [Pubmed]
  11. Islet changes induced by hyperglycemia in rats. Effect of insulin or chlorpropamide therapy. Clark, A., Bown, E., King, T., Vanhegan, R.I., Turner, R.C. Diabetes (1982) [Pubmed]
  12. Segmental occlusion of the pancreatic duct with prolamine to prevent fistula formation after distal pancreatectomy. Konishi, T., Hiraishi, M., Kubota, K., Bandai, Y., Makuuchi, M., Idezuki, Y. Ann. Surg. (1995) [Pubmed]
  13. Effect of in vivo vanadate treatment on insulin receptor tyrosine kinase activity in partially pancreatectomized diabetic rats. Cordera, R., Andraghetti, G., DeFronzo, R.A., Rossetti, L. Endocrinology (1990) [Pubmed]
  14. Persistent hyperinsulinemic hypoglycemia of infancy: long-term octreotide treatment without pancreatectomy. Glaser, B., Hirsch, H.J., Landau, H. J. Pediatr. (1993) [Pubmed]
  15. Surgical alterations of the pancreas and insulin-independent glucose disposal. Krusch, D.A., Pruett, T.L., Cornett, G., Hanks, J.B. J. Surg. Res. (1992) [Pubmed]
  16. Impaired pancreatic duct-cell growth in focal areas of regeneration after partial pancreatectomy in the adult Goto-Kakizaki rat, a spontaneous model of non-insulin dependent diabetes mellitus. Plachot, C., Portha, B. Histochem. J. (2001) [Pubmed]
  17. Changes in gene expression during pancreatic regeneration: activation of c-myc and H-ras oncogenes in the rat pancreas. Calvo, E.L., Dusetti, N.J., Cadenas, M.B., Dagorn, J.C., Iovanna, J.L. Pancreas (1991) [Pubmed]
  18. Hypothalamic 5-HT functional regulation through 5-HT1A and 5-HT2C receptors during pancreatic regeneration. Mohanan, V.V., Khan, R., Paulose, C.S. Life Sci. (2006) [Pubmed]
  19. The effect of pancreatectomy on the uptake of metabolites by the sheep fetus. Fowden, A.L., Silver, M., Comline, R.S. Quarterly journal of experimental physiology (Cambridge, England) (1986) [Pubmed]
  20. Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly. Federici, M., Giaccari, A., Hribal, M.L., Giovannone, B., Lauro, D., Morviducci, L., Pastore, L., Tamburrano, G., Lauro, R., Sesti, G. Diabetes (1999) [Pubmed]
  21. Reply to comment on: Patti ME, McMahon G, Mun EC et al. (2005) Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia 48:2236-2240. Patti, M.E., Bonner-Weir, S., Goldfine, A. Diabetologia (2006) [Pubmed]
  22. Gut-hormone profile in totally pancreatectomised patients. Dammann, H.G., Besterman, H.S., Bloom, S.R., Schreiber, H.W. Gut (1981) [Pubmed]
  23. Persistent pancreatic glucagon but not insulin response to arginine in pancreatectomized dogs. Mashiter, K., Harding, P.E., Chou, M., Mashiter, G.D., Stout, J., Diamond, D., Field, J.B. Endocrinology (1975) [Pubmed]
  24. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. Bonner-Weir, S., Trent, D.F., Weir, G.C. J. Clin. Invest. (1983) [Pubmed]
  25. Gastric mucosal damage in experimental diabetes in rats: role of endogenous glutathione. Goldin, E., Ardite, E., Elizalde, J.I., Odriozola, A., Panés, J., Piqué, J.M., Fernández-Checa, J.C. Gastroenterology (1997) [Pubmed]
  26. Pancreas acinar cell regeneration and histone (H1 and H10) modifications after partial pancreatectomy or after a protein-free ethionine regimen. Varricchio, F., Mabogunje, O., Kim, D., Fortner, J.G., Fitzgerald, P.J. Cancer Res. (1977) [Pubmed]
  27. Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats. Leahy, J.L., Bumbalo, L.M., Chen, C. Diabetes (1994) [Pubmed]
  28. Nonhuman primates as models for the study of human diabetes mellitus. Howard, C.F. Diabetes (1982) [Pubmed]
  29. Cushing's syndrome due to ectopic proopiomelanocortin gene expression by islet cell carcinoma of the pancreas. Melmed, S., Yamashita, S., Kovacs, K., Ong, J., Rosenblatt, S., Braunstein, G. Cancer (1987) [Pubmed]
  30. Phenotype modulation in cultures of vascular smooth muscle cells from diabetic rats: association with increased nitric oxide synthase expression and superoxide anion generation. Pandolfi, A., Grilli, A., Cilli, C., Patruno, A., Giaccari, A., Di Silvestre, S., De Lutiis, M.A., Pellegrini, G., Capani, F., Consoli, A., Felaco, M. J. Cell. Physiol. (2003) [Pubmed]
  31. Nestin expression in pancreatic exocrine cell lineages. Delacour, A., Nepote, V., Trumpp, A., Herrera, P.L. Mech. Dev. (2004) [Pubmed]
  32. Dual role of the tyrosine kinase GTK and the adaptor protein SHB in beta-cell growth: enhanced beta-cell replication after 60% pancreatectomy and increased sensitivity to streptozotocin. Annerén, C. J. Endocrinol. (2002) [Pubmed]
  33. Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats. Mohanan, V.V., Chathu, F., Paulose, C.S. Mol. Cell. Biochem. (2005) [Pubmed]
  34. Vascularized islet cell transplantation in miniature Swine: islet-kidney allografts correct the diabetic hyperglycemia induced by total pancreatectomy. Kumagai, N., LaMattina, J.C., Kamano, C., Vagefi, P.A., Barth, R.N., O'Neil, J.J., Yamamoto, S., Moran, S.G., Utsugi, R., Sachs, D.H., Yamada, K. Diabetes (2002) [Pubmed]
  35. A prospective randomized trial comparing R1 subtotal gastrectomy with R3 total gastrectomy for antral cancer. Robertson, C.S., Chung, S.C., Woods, S.D., Griffin, S.M., Raimes, S.A., Lau, J.T., Li, A.K. Ann. Surg. (1994) [Pubmed]
  36. Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy. Del Prato, S., Vigili de Kreutzenberg, S., Trevisan, R., Duner, E., Avogaro, A., Nosadini, R., Baccaglini, U., Tremolada, C., Tiengo, A. Diabetologia (1985) [Pubmed]
  37. Technetium-99m sulfur colloid spleen imaging following partial pancreatectomy and splenic artery and vein resection. Kuni, C.C., Crass, J.R., duCret, R.P., Boudreau, R.J., Loken, M.K. J. Nucl. Med. (1989) [Pubmed]
  38. The metabolic impact of rapamycin (sirolimus) in chronic canine islet graft recipients. Kneteman, N.M., Lakey, J.R., Wagner, T., Finegood, D. Transplantation (1996) [Pubmed]
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