Chemical Compound Review:
Alloxan 1,3-diazinane-2,4,5,6-tetrone
Synonyms:
ALLOXANE, Mesoxalylurea, mesoxalyl-Urea, Alloxan 7169, SureCN64547, ...
- Glucagon: role in the hyperglycemia of diabetes mellitus. Dobbs, R., Sakurai, H., Sasaki, H., Faloona, G., Valverde, I., Baetens, D., Orci, L., Unger, R. Science (1975)
- Increased insulin binding by hepatic plasma membranes from diabetic rats: normalization by insulin therapy. Davidson, M.B., Kaplan, S.A. J. Clin. Invest. (1977)
- Relationship of an abnormal plasma lipoprotein to protection from atherosclerosis in the cholesterol-fed diabetic rabbit. Brecher, P., Chobanian, A.V., Small, D.M., Van Sickle, W., Tercyak, A., Lazzari, A., Baler, J. J. Clin. Invest. (1983)
- Arrhythmia susceptibility and myocardial composition in diabetes. Influence of physical conditioning. Bakth, S., Arena, J., Lee, W., Torres, R., Haider, B., Patel, B.C., Lyons, M.M., Regan, T.J. J. Clin. Invest. (1986)
- Determinants of the selective toxicity of alloxan to the pancreatic B cell. Malaisse, W.J., Malaisse-Lagae, F., Sener, A., Pipeleers, D.G. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Effect of hyperglycemia on pain threshold in alloxan-diabetic rats. Lee, J.H., Cox, D.J., Mook, D.G., McCarty, R.C. Pain (1990)
- Effects of alloxan induced diabetes on the feeding patterns of rats. Thomas, D.W., Scharrer, E., Mayer, J. Physiol. Behav. (1976)
- Further analysis of the resistance of the diabetic rat to d-amphetamine. Marshall, J.F. Pharmacol. Biochem. Behav. (1978)
- Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets. Yamamoto, H., Uchigata, Y., Okamoto, H. Nature (1981)
- Intraventricular alloxan eliminates feeding elicited by 2-deoxyglucose. Woods, S.C., McKay, L.D. Science (1978)
- Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats. Chick, W.L., Perna, J.J., Lauris, V., Low, D., Galletti, P.M., Panol, G., Whittemore, A.D., Like, A.A., Colton, C.K., Lysaght, M.J. Science (1977)
- Anomeric specificty of 3-0-methyl-D-glycopyranose against alloxan diabetes. Rossini, A.A., Cahill, G.F., Jeanioz, D.A., Jeanioz, R.W. Science (1975)
- Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. Larger, E., Bécourt, C., Bach, J.F., Boitard, C. J. Exp. Med. (1995)
- Enzymatic reduction of alloxan by thioredoxin and NADPH-thioredoxin reductase. Holmgren, A., Lyckeborg, C. Proc. Natl. Acad. Sci. U.S.A. (1980)
- Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice. Ho, E., Chen, G., Bray, T.M. FASEB J. (1999)
- ALS/Lt: a new type 2 diabetes mouse model associated with low free radical scavenging potential. Mathews, C.E., Bagley, R., Leiter, E.H. Diabetes (2004)
- Nicotinamide does not protect islet B-cell metabolism against alloxan toxicity. Sandler, S., Welsh, M., Andersson, A. Diabetes (1984)
- Streptozocin- and alloxan-induced H2O2 generation and DNA fragmentation in pancreatic islets. H2O2 as mediator for DNA fragmentation. Takasu, N., Komiya, I., Asawa, T., Nagasawa, Y., Yamada, T. Diabetes (1991)
- Evidence for presence of insulin receptors in rat islets of Langerhans. Verspohl, E.J., Ammon, H.P. J. Clin. Invest. (1980)
- 3,5-Dimethyl-3'-isopropyl-l-thyronine therapy in diabetic pregnancy: stimulation of rabbit fetal lung phospholipids. Neufeld, N., Melmed, S. J. Clin. Invest. (1981)
- Differential regulation of multiple hepatic protein tyrosine phosphatases in alloxan diabetic rats. Boylan, J.M., Brautigan, D.L., Madden, J., Raven, T., Ellis, L., Gruppuso, P.A. J. Clin. Invest. (1992)
- Pitfalls in the use of lead nitrate for the histochemical demonstration of adenylate cyclase activity. Lemay, A., Jarett, L. J. Cell Biol. (1975)
- Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunction. Musicki, B., Kramer, M.F., Becker, R.E., Burnett, A.L. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Insulin and glucose as modulators of the amino acid-induced glucagon release in the isolated pancreas of alloxan and streptozotocin diabetic rats. Pagliara, A.S., Stillings, S.N., Haymond, M.W., Hover, B.A., Matschinsky, F.M. J. Clin. Invest. (1975)
- Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. Korsgren, O., Jansson, L., Sandler, S., Andersson, A. J. Clin. Invest. (1990)
- Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. Gupta, S., Sussman, I., McArthur, C.S., Tornheim, K., Cohen, R.A., Ruderman, N.B. J. Clin. Invest. (1992)
- Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. Gruppuso, P.A., Boylan, J.M., Posner, B.I., Faure, R., Brautigan, D.L. J. Clin. Invest. (1990)
- Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Eizirik, D.L., Pipeleers, D.G., Ling, Z., Welsh, N., Hellerström, C., Andersson, A. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Adaptive regulation of hepatic bile salt transport: effects of alloxan diabetes in the rat. Icarte, M.A., Pizarro, M., Accatino, L. Hepatology (1991)
- Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Yamagami, T., Miwa, A., Takasawa, S., Yamamoto, H., Okamoto, H. Cancer Res. (1985)
- Inhibition of alloxan action in isolated pancreatic islets by superoxide dismutase, catalase, and a metal chelator. Fischer, L.J., Hamburger, S.A. Diabetes (1980)
- Hydrogen peroxide inhibits IL-12 p40 induction in macrophages by inhibiting c-rel translocation to the nucleus through activation of calmodulin protein. Khan, N., Rahim, S.S., Boddupalli, C.S., Ghousunnissa, S., Padma, S., Pathak, N., Thiagarajan, D., Hasnain, S.E., Mukhopadhyay, S. Blood (2006)
- Diabetic embryopathy in C57BL/6J mice. Altered fetal sex ratio and impact of the splotch allele. Machado, A.F., Zimmerman, E.F., Hovland, D.N., Weiss, R., Collins, M.D. Diabetes (2001)
- Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells. de-Mello, M.A., Flodström, M., Eizirik, D.L. Biochem. Pharmacol. (1996)
- Aldose reductase and sorbitol dehydrogenase distribution in rat kidney. Corder, C.N., Collins, J.G., Brannan, T.S., Sharma, J. J. Histochem. Cytochem. (1977)
- Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice. Wang, J., Gåfvels, M., Rudling, M., Murphy, C., Björkhem, I., Einarsson, C., Eggertsen, G. Biochem. Biophys. Res. Commun. (2006)
- Large scale isolation, growth, and function of porcine neonatal islet cells. Korbutt, G.S., Elliott, J.F., Ao, Z., Smith, D.K., Warnock, G.L., Rajotte, R.V. J. Clin. Invest. (1996)
- Migrating myoelectrical complex of the small intestine. An intrinsic activity mediated by the vagus. Ruckebusch, Y., Bueno, L. Gastroenterology (1977)