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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ketobemidone may alter busulfan pharmacokinetics during high-dose therapy.

The authors report a possible interaction between ketobemidone and busulfan during myeloablative treatment of a patient with acute myeloid leukemia. At the time of admission, the patient was receiving ketobemidone 1,000 mg/d as analgesic for a rectal fissure. The patient started conditioning prior to bone marrow transplantation with busulfan (1 mg/kg x 4 for 4 days). High busulfan plasma concentrations were observed after the first dose and the next doses were reduced to 0.7 mg/kg. The kinetics of both drugs revealed that an increase in ketobemidone concentration was followed by an increase in busulfan levels. Substituting ketobemidone with morphine resulted in a decrease in busulfan concentration despite increasing the dose once more to 1 mg/kg.[1]


  1. Ketobemidone may alter busulfan pharmacokinetics during high-dose therapy. Hassan, M., Svensson, J.O., Nilsson, C., Hentschke, P., Al-Shurbaji, A., Aschan, J., Ljungman, P., Ringdén, O. Therapeutic drug monitoring. (2000) [Pubmed]
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